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Analysis of osteoclast niche regulated by correction power load

Research Project

Project/Area Number 21792104
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

ARAI Atsushi  Matsumoto Dental University, 歯学部, 助教 (00532772)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords破骨細胞前駆細胞 / RANK / RANKL / c-Fos / M-CSF / マクロファージ / メカニカルストレス / 破骨細胞 / H-CSF / QOP
Research Abstract

This research revealed that c-Fos, but not RANKL, is required for the up-regulation of RANK in osteoclast precursors. Then, we analyzed the mechanism of c-Fos-mediated up-regulation of RANK in osteoclast precursors. Researchers have believed that that c-Fos plays essential roles not only in RANKL-induced formation of osteoclasts but also in M-CSF-induced formation of osteoclast precursors.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2010

    • Author(s)
      Takahashi N, Muto A, Arai A, Mizoguchi T.
    • Journal Title

      Adv Exp Med Biol. 658

      Pages: 21-30

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2010

    • Author(s)
      Naoyuki Takahashi
    • Journal Title

      Adv Exp Med Biol

      Volume: 658 Pages: 21-30

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.2009

    • Author(s)
      Mizoguchi T Mizoguchi T, Muto A, Udagawa N, Arai A, Yamashita T, Hosoya A, Ninomiya T, Nakamura H, Yamamoto Y, Kinugawa S, Nakamura M, Nakamichi Y, Kobayashi Y, Nagasawa S, Oda K, Tanaka H, Tagaya M, Penninger JM, Ito M, Takahashi N
    • Journal Title

      Journal of Cell Biology 184

      Pages: 541-554

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 海外文献紹介「インターフェロン調節因子8は破骨細胞形成を抑制することにより骨代謝を制御する」2009

    • Author(s)
      荒井敦
    • Journal Title

      骨粗鬆症治療 Vol.8 No.4

      Pages: 89-89

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of cell cycle-arrested quiescent osteoclast precursors in vivo2009

    • Author(s)
      Naoyuki Takahashi
    • Journal Title

      Adve Exp Med Biol. 658

      Pages: 21-30

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インターフェロン調節因子8は破骨細胞形成を抑制することにより骨代謝を制御する2009

    • Author(s)
      荒井敦
    • Journal Title

      骨粗鬆症治療 8

      Pages: 89-89

    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of cell cycle-arrested quiescent osteoclast precursors2009

    • Author(s)
      溝口利英, 武藤昭紀, 宇田川信之, 荒井敦, 小林泰浩, Penninger JM, 高橋直之
    • Organizer
      第26回内藤カンファレンスオステオバイオロジー
    • Place of Presentation
      兵庫・淡路夢舞台国際会議場
    • Year and Date
      2009-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of cell cycle-arrested quiescent osteoclast precursors2009

    • Author(s)
      溝口利英
    • Organizer
      第26回内藤カンファレンス オステオバイオロジー
    • Place of Presentation
      兵庫・淡路夢舞台国際会議場
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 破骨細胞前駆細胞の同定と動態解析2009

    • Author(s)
      溝口利英, 武藤昭紀, 荒井敦, 小林泰浩, 中道裕子, 宇田川信之, 高橋直之
    • Organizer
      運動器科学研究会(第10回)
    • Place of Presentation
      東京・東京ステーションコンファレンス
    • Year and Date
      2009-09-18
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] c-Fos遺伝子欠損マウスを用いた静止期破骨細胞前駆細胞(QOP)の解析-c-FosはRANKの発現を誘導しQOP分化を制御する2009

    • Author(s)
      荒井敦, 溝口利英, 武藤昭紀, 小林泰浩, 川原一郎, 中村美どり, 宇田川信之, 山田一尋, 高橋直之
    • Organizer
      日本骨代謝学会学術集会(第27回)
    • Place of Presentation
      大阪・国際会議所
    • Year and Date
      2009-07-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 細胞周期の停止した静止期破骨細胞前駆細胞(QOP)の性状解析-QOPはB細胞マーカーを発現している2009

    • Author(s)
      武藤昭紀, 溝口利英, 荒井敦, 小林泰浩, 中道裕子, 吉成伸夫, 宇田川信之, 高橋直之
    • Organizer
      日本骨代謝学会学術集会(第27回)
    • Place of Presentation
      大阪・国際会議所
    • Year and Date
      2009-07-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 「ミニシンポジウム」骨芽細胞/ストローマ細胞が支持する破骨細胞ニッチ2009

    • Author(s)
      溝口利英
    • Organizer
      日本骨代謝学会学術集会(第27回)
    • Place of Presentation
      大阪・国際会議所
    • Year and Date
      2009-07-24
    • Related Report
      2010 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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