• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

P.gingivalis target DC-SIGN to escape Th1-type immune response.

Research Project

Project/Area Number 21792108
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionTohoku University

Principal Investigator

TADA Hiroyuki  Tohoku University, 病院, 医員 (70431632)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords免疫学 / 樹状細胞 / 細胞・組織 / サイトカイン / DC-SIGN
Research Abstract

Dendritic cells (DCs) express C-type lectin receptors (CLRs). Pathogenic bacteria subvert DC functions to escape immune surveillance by targeting the CLRs including DC-SIGN. In this study, we investigated the role played by Nod proteins in inducing the cross-priming of CD8^+T cells, and we demonstrate that Nod ligands significantly enhance the induction of DC-mediated cross-priming.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Phosphate increases bone morphogenetic protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells.2011

    • Author(s)
      Tada, H., Nemoto, E., Foster, B.L., Somerman, M.J., Shimauchi, H.
    • Journal Title

      Bone. 48印刷中

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphate increases bone morphogenetic protein-2 expression through cAMP-dependent protein kinase and ERK1/2 pathways in human dental pulp cells2011

    • Author(s)
      Tada, H.
    • Journal Title

      Bone

      Volume: (印刷中 未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells.2010

    • Author(s)
      Tada, H., Nemoto, E., Kanaya, S., Hamaji, N., Sato, H., Shimauchi, H.
    • Journal Title

      Biochem.Biophys.Res.Commun. 394

      Pages: 1093-1097

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nucleotide-binding oligomerization domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo.2010

    • Author(s)
      Asano, J., Tada, H., Onai, N., Sato, T., Horie, Y., Fujimoto, Y., Fukase, K., Suzuki, A., Mak, T.W., Ohteki, T.
    • Journal Title

      J.Immunol. 184

      Pages: 736-745

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development.2010

    • Author(s)
      Hasegawa, M., Osaka, T., Tawaratsumida, K., Yamazaki, T., Tada, H., Chen, G.Y., Tsuneda, S., Nunez, G., Inohara, N.
    • Journal Title

      Infect.Immun. 78

      Pages: 639-650

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells2010

    • Author(s)
      Tada, H.
    • Journal Title

      Biochem.Biophys.Res.Commun. 394

      Pages: 1093-1097

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleotide-binding oligomerization domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo2010

    • Author(s)
      Asano, J.
    • Journal Title

      J.Immunol. 184

      Pages: 736-745

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development2010

    • Author(s)
      Hasegawa, M.
    • Journal Title

      Infect.Immun. 78

      Pages: 639-650

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 細胞外リン酸はPitおよびERK1/2を介してヒト歯髄細胞からBMP-2を誘導する2010

    • Author(s)
      多田浩之、根本英二、島内英俊
    • Organizer
      第132回日本歯科保存学会春季学術大会(ポスター発表)
    • Place of Presentation
      熊本市
    • Year and Date
      2010-06-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞外リン酸はPitおよびERK1/2を介してヒト歯髄細胞からBMP-2を誘導する2010

    • Author(s)
      多田浩之
    • Organizer
      第132回日本歯科保存学会春季学術大会
    • Place of Presentation
      熊本県熊本市
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞外リン酸によるヒト歯髄細胞からのbone morphogenetic protein-2発現誘導2009

    • Author(s)
      多田浩之、根本英二、金谷聡介、島内英俊
    • Organizer
      第131回日本歯科保存学会秋季学術大会(口頭発表)
    • Place of Presentation
      仙台市
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞外リン酸によるヒト歯髄細胞からの bone morphogenetic protein-2発現誘導2009

    • Author(s)
      多田浩之
    • Organizer
      第131回日本歯科保存学会秋季学術大会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Remarks] 日本歯科保存学会デンツプライ賞受賞平成22年10月28日

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi