The role of regulatory T cell in Periodontitis regions
Project/Area Number |
21792113
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Periodontal dentistry
|
Research Institution | Niigata University |
Principal Investigator |
ITO Harue Niigata University, 医歯学系, 助教 (30397145)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 制御性T細胞 / T細胞クローン / 歯周炎 |
Research Abstract |
Periodontal bacteria are the causative agents in periodontitis, but subsequent progression and disease severity are thought to be determined by the host immune responses. It was reported that CD4^+CD25^+ regulate T cell existed and might have roles in progress of periodontitis. The aim of this study was to make CD4+CD25+ Tr cell's roles in periodontitis. CD4^+CD25^+ Tr suppressed proliferation of CD4^+CD25- T cells. After CD4^+CD25^+ Tr was stimulate by Dynabeads HumanT-Activator CD3/CD28, The ability of suppression was reduced. This was suggested that the ability of suppression in CD4^+CD25^+ Tr might be reduced by the stimulation.
|
Report
(3 results)
Research Products
(9 results)