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Analysis of novel periodontal ligament-specific molecules identified in human periodontal ligament full-length cDNA database.

Research Project

Project/Area Number 21792119
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

OZAWA Yasuhiro  Osaka University, 歯学部附属病院, 医員 (30448146)

Research Collaborator FUJIHARA Chiharu  大阪大学, 歯学部附属病院, 専修歯科医
KAJIKAWA Tetuhiro  大阪大学, 大学院・歯学研究科, 大学院生
OZAKI Nobuhiro  大阪大学, 大学院・歯学研究科, 大学院生
AWATA Toshihito  大阪大学, 大学院・歯学研究科, 大学院生
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords歯根膜組織完全長cDNAライブラリ / ヒト歯根膜組織完全長cDNAデータベース / 新規遺伝子 / 歯根膜組織 / FLJ25143遺伝子 / Cathepsin K
Research Abstract

In this study, I analyzed human periodontal ligament full-length cDNA library ( Full-PerioGen database ) and found several genes which were highly expressed in human periodontal ligament tissues. Among of these genes, I focused on FLJ25143 and Cathepsin K of which functions in periodontal ligament were not known. I found that FLJ25143 and Cathepsin K regulated periodontal ligament cell functions, suggesting involvement of these molecules in homeostasis, repair and regeneration of periodontium.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2010

All Presentation (4 results)

  • [Presentation] ヒト歯根膜組織完全長cDNAライブラリーを用いたCathepsin Kの同定および機能解析2010

    • Author(s)
      尾崎亘弘、山田聡、藤原千春、田内拓史、梶川哲宏、粟田敏仁、小澤康宏、村上伸也
    • Organizer
      第133回日本歯科保存学会秋季大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト歯根膜組織完全長cDNAライブラリーを用いたCathepsin Kの同定および機能解析2010

    • Author(s)
      尾崎亘弘
    • Organizer
      日本歯科保存学会2010年度秋季学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of Cathepsin K in human periodontal ligament cells.2010

    • Author(s)
      N.OZAKI, S.YAMADA, C.FUJIHARA, T.TAUCHI, T.KAJIKAWA, T.AWATA, Y.OZAWA, S.MURAKAMI
    • Organizer
      第58回国際歯科研究学会日本部会(JADR)
    • Place of Presentation
      小倉市
    • Year and Date
      2010-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Cathepsin Kexpression in human periodontal ligament cells.2010

    • Author(s)
      N.OZAKI, S.YAMADA, C.FUJIHARA, T.TAUCHI, T.KAJIKAWA, T.AWATA, Y.OZAWA, S.MURAKAMI
    • Organizer
      89^<th> IADR
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2010-03-18
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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