The Clarification of pathologic regulation via Toll-like receptors on senescent lymphatic endothelial cells in oral cavity
Project/Area Number |
21792138
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Social dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
KUROSHIMA Shinichiro Hokkaido University, 大学院・歯学研究科, 助教 (40443915)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | リンパ管内皮細胞 / ケモカイン / Toll様受容体 / 免疫老化 / リンパ内皮細胞 / 免疫 / 口腔組織 / 老化 / TLR4 / TLR2 / 白血球接着因子 / 炎症 |
Research Abstract |
I investigated to clarify the pathologic regulation via toll-like receptors on senescent lymphatic endothelium in oral cavity. It was found that immune responses through toll-like receptors on lymphatic endothelium were downregulated in ageing. It is possible that lymphatic endothelium may regulate immunesenescence system via toll-like receptors.
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Report
(3 results)
Research Products
(9 results)
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[Presentation]2011
Author(s)
Kuroshima S, L.McCAULEY, J.YAMASHITA
Organizer
89th General Session & Exhibition of the IADR
Place of Presentation
カリフォルニア, アメリカ合衆国Selected Oral Presentation. Abstract No. 0423
Year and Date
2011-03-17
Related Report
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