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Promotion of the salivary glands branching for treatment of dry mouth

Research Project

Project/Area Number 21792154
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionTohoku University

Principal Investigator

FUKUMOTO Emiko  Tohoku University, 病院, 助教 (10264251)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords予防歯科学 / 唾液腺 / 発生 / 口腔乾燥症 / 腺分岐
Research Abstract

GAP junction Inhibitor related to calcium and IP3 transport inhibit the PDGF-mediated salivary glands branching. PDGF induced FGF7 and FGF10 expression in mesenchymal tissue of salivary glands. We analyzed about the MAPK pathway. PDGF induced phosphorylation of ERK1/2 in developing salivary glands. It indicates that activation of MAPK pathway on epithelial cells involves the branching of salivary glands. In Cx43 knockout mice, branching of salivary gland was inhibited compared with control mice, indicating that Cx43 may be important for salivary gland morphogenesis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results)

  • [Journal Article] Expression and functions of neurotrophic factors in tooth development.2011

    • Author(s)
      Iwamoto T, Yamada A, Arakaki M, Sugawara Y, Ono M, Futaki M, Yoshizaki K, Fukumoto E, Nakamura T, Fukumoto S.
    • Journal Title

      J Oral Biosci. 53(1)

      Pages: 13-21

    • NAID

      10027793552

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression and functions of neurotrophic factors in tooth development2011

    • Author(s)
      Iwamoto T, Yamada A, Fukumoto E, Fukumoto S., et al.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 53(1) Pages: 13-21

    • NAID

      10027793552

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts.2009

    • Author(s)
      Iwamoto T, Yamada A, Yuasa K, Fukumoto E, Nakamura T, Fujiwara T, Fukumoto S.
    • Journal Title

      54(10)

      Pages: 963-969

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation.2009

    • Author(s)
      Sonoda A, Iwamoto T, Nakamura T, Fukumoto E, Yoshizaki K, Yamada A, Arakaki M, Harada H, Nonaka K, Nakamura S, Yamada Y, Fukumoto S
    • Journal Title

      284(40)

      Pages: 176-184

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts2009

    • Author(s)
      Iwamoto T, Yamada A, Yuasa K, Fukumoto E, Nakamura T, Fujiwara T, Fukumoto S.
    • Journal Title

      Arch Oral Biol. 54(10)

      Pages: 963-969

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation2009

    • Author(s)
      Sonoda A, Iwamoto T, Nakamura T, Fukumoto E, Yoshizaki K, Yamada A, Arakaki M, Harada H, Nonaka K, Nakamura S, Yamada Y, Fukumoto S.
    • Journal Title

      J Biol Chem. 284(40)

      Pages: 176-184

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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