|Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
We investigated salivary levels of 4 periodontopathic bacteria, Porphyromonas gingivalis ( Pg), Tannerella forsythensis ( Tf), Prevotella intermedia ( Pi) and Aggregatibacter actinomycetemcomitans ( Aa), in 80 pregnant women at 10-13 weeks and 30-35 weeks of pregnancy by PCR-invader analysis. We then evaluated the relationships with oral symptoms related to periodontal diseases, including gingival bleeding, swollen gums, loose teeth, bad breath and oral dryness. Detection rates of Aa, Pi, Pg and Tf among the women were 18, 23, 20 and 98%, respectively, at 10-13 weeks of pregnancy, and 8, 21, 24 and 89%, respectively, at 30-35weeks of pregnancy, showing no significant differences between the two periods. Pregnant women in whom Pi was detected during both periods had a significantly higher incidence of gingival bleeding (p<0.05), swollen gums (p<0.01), loose teeth (p<0.05) and bad breath (p<0.05) as compared to pregnant women in whom Pi was not detected during both periods. Similarly, pregnant women in whom Pg was detected during both periods had a significantly higher incidence of gingival bleeding (p<0.05). To maintain oral health during pregnancy, more aggressive intervention may be necessary for women when Pi or Pg is detected on salivary examination.