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Preparation of chitosan microspheres for the medical application

Research Project

Project/Area Number 21800035
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionOkayama University

Principal Investigator

SHIROSAKI Yuki  Okayama University, 大学院・自然科学研究科, 助教 (40533956)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,678,000 (Direct Cost: ¥2,060,000、Indirect Cost: ¥618,000)
Fiscal Year 2010: ¥1,274,000 (Direct Cost: ¥980,000、Indirect Cost: ¥294,000)
Fiscal Year 2009: ¥1,404,000 (Direct Cost: ¥1,080,000、Indirect Cost: ¥324,000)
Keywordsキトサン / ミクロ粒子 / ミクロカプセル / 薬物徐放 / 細胞適合性 / 有機-無機複合体 / 骨形成
Research Abstract

In this study, Porous particles and capsules were prepared to recover of the damaged human tissues. Chitosan and γ-glycidoxypropyltrymethoxysilane (GPTMS) were used as the starting materials. Porous particles were prepared by dropping precursor sol with CaCl_2 or without into liquid nitrogen. Obtained porous particles had about 2 mm in diameter and 10-30μm in pore size. HAp particles of about 1μm in diameter deposited on the pore surface by soaking thus obtained hybrid parties in 0.01 M Na2HPO4 solution at 80℃ for 7 days. Bovine serum albumin (BSA) adsorbed much on the chitosan-GPTMS particles. Capsules were prepared by dropping carboxymethylcellulose into chitosan-GPTMS sols. The releasing of bioactive molecules included into the capsules was controlled by the cross-linking degree. Moreover the capsules did not show the cytotoxicity.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All Other

All Remarks (2 results)

  • [Remarks] ホームページ

    • URL

      http://apatite.biotech.okayama-u.ac.jp/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://apatite.biotech.okayama-u.ac.jp/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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