Infection risk to wildlife populations and immune suppression induced by environmental chemicals

• Project/Area Number: 21810001
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Environmental impact assessment/Environmental policy
• Research Institution: Hokkaido University
• Principal Investigator: IKENAKA Yoshinori Hokkaido University, (連合)大学院・獣医学研究科, 講師 (40543509)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000); Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000); Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
• Keywords: 免疫かく乱 / 環境汚染バイオマーカー / 重金属 / アフリカ / 飼育動物 / GIS / 環境化学物質 / 感染症 / 免疫抑制 / サイトカイン / インターロイキン / アフリカ地域 / メタロチオネイン / 野生動物

Research Abstract

We investigated about "disease for wildlife caused by environmental chemicals", in particular "immunosuppression" focusing on at the field level. We did our investigation in Republic of Zambia the major industry of the country is mining activity. From our results, we found that due to mining activity, the inflammatory cytokines levels and oxidative stress marker levels in domestic cattle and wild rodents were consider affected by heavy metals exposure. Furthermore, we analyze the correlation between GIS heavy metal concentration data and immune disruption. The results indicated that we couldn't found any correlations among immune disruption, heavy metal concentration in soil, and MT expression levels. Our results suggested that other strong factors such as feeding habitat, infection are affected to the correlation.

Research Products

• [Journal Article] Heavy metal contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia. (2011)
  • Author(s): Nakayama MMS, Ikenaka Y, Muzandu K, Hamada K, Choongo K, Oroszlany B, Teraoka H, Mizuno N, Ishizuka M
  • Journal Title: Environmental Pollution 159 Pages: 175-181
  • Peer Reviewed
• [Journal Article] Heavy metal contamination of soil and sediment in Zambia. (2011)
  • Author(s): Ikenaka Y., et al.
  • Journal Title: African Journal of Environmental Science and Tech nology Volume: 4 Pages: 729-739
  • NAID: 120005761588
  • Peer Reviewed
• [Journal Article] Metal and metalloid contamination in roadside soil and wild rats around a Pb-Zn mine in Kabwe, Zambia (2011)
  • Author(s): Nakayama SMM., Et al.
  • Journal Title: Environ Pollut. Volume: 159 Pages: 175-181
  • Peer Reviewed
• [Journal Article] Heavy metal contamination of soil and sediment in Zambia. (2010)
  • Author(s): Ikenaka Y, Nakayama SMM, Muzandu K, Choongo K, Teraoka H, Mizuno N, Ishizuka M
  • Journal Title: African Journal of Environmental Science and Technology 4 Pages: 729-739
  • NAID: 120005761588
  • Peer Reviewed
• [Journal Article] Heavy metal accumulation in lake sediments, fish (Oreochromis niloticus and Serranochromis thumbergi) and crayfish (Cherax quadricarinatus) in Lake Itezhi-tezhi and Lake Kariba, Zambia. (2010)
  • Author(s): Nakayama MMS, Ikenaka Y, Muzandu K, Choongo K, Oroszlany B, Teraoka H, Mizuno N, Ishizuka M
  • Journal Title: Arch Environ Contam Toxicol. 59 Pages: 291-300
  • NAID: 120002248697
  • Peer Reviewed
• [Journal Article] Current levels of heavy metal pollution in Africa. (2010)
  • Author(s): Yabe J., et al.
  • Journal Title: J Vet Med Sci. Volume: 72 Pages: 1257-1263
  • Peer Reviewed
• [Journal Article] Heavy metal accumulation in lake sediments, fish (Oreochromis niloticus and Serranochromis thumbergi) and crayfish (Cherax quadricarinatus) in Lake Itezhi-tezhi and Lake Kariba, Zambia. (2010)
  • Author(s): Nakayama MMS., Et al.
  • Journal Title: Arch Environ Contam Toxicol. Volume: 59 Pages: 291-300
  • Peer Reviewed
• [Journal Article] Metabolic activation of heterocyclic amines and expression of CYP1A1 in the tongue (2010)
  • Author(s): Takiguchi M, Darwish WS, Ikenaka Y, Ohno M, Ishizuka M.
  • Journal Title: Toxicol.Sci (In press)
  • NAID: 120002834690
  • Peer Reviewed
• [Journal Article] Heavy metal accumulation in lake sediments, fish(Oreochromisniloticus and Serranochromis thumbergi)and crayfish(Cherax quadricarinatus)in Lake Itezhi-tezhi and Lake Kariba, Zambia. (2010)
  • Author(s): Nakayama MMS, Ikenaka Y, Muzandu K, Choongo K, Oroszlany B, Teraoka H, Mizuno N, Ishizuka M.
  • Journal Title: Arch Environ Contam Toxicol (In press)
  • Peer Reviewed
• [Journal Article] Cytochrome P450 1A dependent activities in deer, cattle, and horses. (2010)
  • Author(s): Darwish WS, Ikenaka Y, Eldaly EA, Ohno M, Sakamoto KQ, Fujita S, Ishizuka M.
  • Journal Title: J Vet Med Sci. (In press)
  • NAID: 130000149970
  • Peer Reviewed
• [Journal Article] Warfarin-resistant of rats in Japan. (2010)
  • Author(s): Tanaka K., Harunari T., Tanikawa T., Ikenaka Y., Ishizuka M.
  • Journal Title: J Vet Med Sci. (In press)
  • NAID: 130004542781
  • Peer Reviewed
• [Journal Article] Protective effect of Pleurotus cornucopiae mushroom on carbon tetra chloride-induced hepatotoxicity. (2010)
  • Author(s): El Bohi KM, Hashimoto Y, Muzandu K, Ikenaka Y, Ibrahim ZS, Kazusaka A, Fujita S, Ishizuka M.
  • Journal Title: J Vet Med Sci. (In press)
  • Peer Reviewed
• [Presentation] The Environmental Pollution in Zambia : Current status of POPs and heavy metals pollution in wildlife and domestic animals in Zambia. (2010)
  • Author(s): Ikenaka Y., et al.
  • Organizer: SETAC North America 31^<st> Annual Meeting
  • Place of Presentation: Oregon Convention Center (Port land), USA
  • Year and Date: 2010-11-10
• [Presentation] The Environmental Pollution in Zambia : Effects of heavy metals observed in wild rats inhabit in mining area in Zambia. (2010)
  • Author(s): Hamada K., et al.
  • Organizer: SETAC North America 31^<st> Annual Meeting
  • Place of Presentation: Oregon Convention Center (Port land), USA
  • Year and Date: 2010-11-10
• [Presentation] ザンビア共和国の鉱床活動による微量元素汚染の野生ラットへの影響 (2010)
  • Author(s): 濱田恭平, 他
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(帯広市)
  • Year and Date: 2010-09-16
• [Presentation] ザンビア共和国をモデルとした微量元素汚染:ウシにおける微量元素濃度とメタロチオネインおよびサイトカインmRNA発現量 (2010)
  • Author(s): 室谷太郎, 他
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(帯広市)
  • Year and Date: 2010-09-16
• [Presentation] The Environmental Pollution in Zambia : Effects of heavy metals observed in wild rats inhabit in mining areas in Zambia. (2010)
  • Author(s): Ikenaka Y, Nakayama S, Hamada K, Muzandu K, Choongo K, Teraoka H, Ishizuka M
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: Zambia Lusaka
  • Year and Date: 2010-09-09
• [Presentation] The Environmental Pollution in Zambia : Effects of heavy metals observed in wild rats inhabit in mining areas in Zambia. (2010)
  • Author(s): Ikenaka Y., et al.
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia, Lusaka, Zambia 招待講演
  • Year and Date: 2010-09-09
• [Presentation] Concentration and bioaccumulation of 10 metals in soil, sediment, plant and hippopotamus (Hippopotamus amphibius L) in the South Luangwa National (2010)
  • Author(s): Nakayama SMM., et al.
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia, Lus aka, Zambia
  • Year and Date: 2010-09-09
• [Presentation] Heavy Metal Pollution in Zambia : The Effects of Heavymetal Pollution in Domestic Cattles (2010)
  • Author(s): Muroya T., et al.
  • Organizer: 2^<nd> International Field Toxicology Symposium in Africa
  • Place of Presentation: University of Zambia, Lusaka, Zambia
  • Year and Date: 2010-09-09
• [Presentation] ザンビアのカブウェ鉱床における重金属汚染～土壌および野生ラットを用いた汚染モニタリング～ (2010)
  • Author(s): 仲山翔太, 他
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 中部大学(名古屋市)
  • Year and Date: 2010-06-22
• [Presentation] ザンビア共和国をモデルとした重金属類汚染～家畜における重金属類濃度とバイオマーカーmRNA発現量～ (2010)
  • Author(s): 室谷太郎, 他
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 中部大学(名古屋市)
  • Year and Date: 2010-06-22
• [Presentation] ザンビア共和国における水圏・陸圏の野生動物への重金属汚染の影響 (2010)
  • Author(s): 濱田恭平, 他
  • Organizer: 国際開発学会第11回春季大会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2010-06-05
• [Presentation] The Environmental Pollution in Zambia : Current status of POPs and heavy metals pollution in wildlife and domestic animals in Zambia. (2010)
  • Author(s): Ikenaka Y, Muroya T, Nakayama S, Saentienchai A, Muzaundu K, Choongo K, John Y, Ishizuka M
  • Organizer: 31st Annual Meeting in North America of the Society of Environmental Toxicology and Chemistry (SETAC)
  • Place of Presentation: Oregon Convention Center, Portland, Oregon, USA
• [Presentation] Sources and distributions of heavy metals in Zambia : Environmental monitoring between lake Kariba and lake Itezhi-tezhi (2009)
  • Author(s): Yoshinori IKENAKA, Shouta M.M.NAKAYAMA, Kaampwe MUZANDU, Kennedy CHOONGO, Hiroki TERAOKA, Naoharu MIZUNO, Mayumi ISHIZUKA
  • Organizer: SETAC North America 30^<th> Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-11-21