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Neural substrates of Kanji writing impairment in Japanese patients with mild Alzheimer's disease

Research Project

Project/Area Number 21830018
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Experimental psychology
Research InstitutionTohoku University

Principal Investigator

HAYASHI Atsuko  Tohoku University, 病院, 教育研究支援者 (20542286)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,639,000 (Direct Cost: ¥2,030,000、Indirect Cost: ¥609,000)
Fiscal Year 2010: ¥1,248,000 (Direct Cost: ¥960,000、Indirect Cost: ¥288,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywordsアルツハイマー病 / 失書
Research Abstract

Mild AD had an impairment in Kanji writing with a large amount of non-response errors, which can be interpreted as deficits of retrieving and retaining morphological Kanji-character images. The non-response errors were correlated with hypoperfusion in the inferior parietal lobule, the posterior middle and inferior temporal gyri, and the posterior middle frontal gyrus in the left hemisphere. Damages to these regions may affect a series of the process from retrieving Kanji representation to activating kinesthetic memory for writing, causing dysfunction of neural network for processing Kanji-character form.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Neural substrates for writing impairments in Japanese patients with mild Alzheimer's disease : a SPECT study2011

    • Author(s)
      Atsuko Hayashi, Hiroshi Nomura, Ruriko Mochizuki, Ayumu Ohnuma, Teiko Kinpara, Kazumasa Ohtomo, Yoshiyuki Hosokai, Toshiyuki Ishioka, Kyoko Suzuki, Etsuro Mori
    • Journal Title

      Neuropsychologia (印刷中)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural substrates for writing impairments in Japanese patients with mild Alzheimer's disease : a SPECT study2011

    • Author(s)
      Atsuko Hayashi, Hiroshi Nomura, Ruriko Mochizuki, Ayumu Ohnuma, Teiko Kinpara, Kazumasa Ohtomo, Yoshiyuki Hosokai, Toshiyuki Ishioka, Kyoko Suzuki, Etsuro Mori
    • Journal Title

      Neuropsychologia

      Volume: 印刷中(未定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 軽症アルツハイマー病における書字障害と局所脳血流との関連-^<123>I-IMP SPECTのSPM解析-2010

    • Author(s)
      林敦子,野村宏,望月るり子,大沼歩,金原禎子,大友一匡,細貝良行,石岡俊之,鈴木匡子,森悦朗
    • Journal Title

      東北脳循環カンファランス 16

      Pages: 9-11

    • Related Report
      2010 Final Research Report
  • [Journal Article] 軽症アルツハイマー病における書字障害と局所脳血流との関連-123I-IMP SPECTのSPM解析-2010

    • Author(s)
      林敦子, 野村宏, 望月るり子, 大沼歩, 金原禎子, 大友一匡, 細貝良行石岡俊之, 鈴木匡子, 森悦朗
    • Journal Title

      東北脳循環カンファランス

      Volume: 16 Pages: 9-11

    • Related Report
      2010 Annual Research Report
  • [Presentation] アルツハイマー病にみられる書き誤りと局所脳血流との関連2010

    • Author(s)
      林敦子
    • Organizer
      日本心理学会第74回大会
    • Place of Presentation
      大阪大学
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Neural bases of Kanji writing impairment in Japanese patients with mild Alzheimer's disease.2010

    • Author(s)
      林敦子
    • Organizer
      International Neuropsychological Society
    • Place of Presentation
      Poland, Krakow
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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