| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
|---|
| Research Abstract |
The dynamics of cholesterol molecules in membrane is of importance in relation to various kinds of diseases such as arteriosclerosis. In this study, we focused on the solvation states of the hydrophobic model solutes in membrane and the dynamics of the hydration state at the surface between the hydrophilic portion of the membrane and the water pool. The model systems suitable for the dynamic modes of interest are explored and established, and the dynamic effects of cholesterol on membrane are elucidated by using the solution-state NMR and molecular dynamics simulation.
|
