• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of b-TrCP in spermatogenesis.

Research Project

Project/Area Number 21870006
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionTohoku University

Principal Investigator

NAKANO Seiji  Tohoku University, 大学院・医学系・研究科, 助手 (00529448)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,756,000 (Direct Cost: ¥2,120,000、Indirect Cost: ¥636,000)
Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2009: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
Keywordsユビキチンリガーゼ / 生殖細胞 / ノックアウトマウス / 不妊 / 雄生殖細胞 / タンパク質分解 / 幹細胞
Research Abstract

Spermatogonia-specific ss-TrCP knockout mice showed impairment of spermatogenesis. I observed reduction of the weight of testis to leb than 30% compared to that of control mice and histopathological abnormality with cavitation. On the other hand, sertoli cells specific knockout mice showed little effect on spermatogenesis. These data suggest that ss-TrCP play a critical role during spermatogenesis.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (8 results) Remarks (4 results)

  • [Journal Article] Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines.2011

    • Author(s)
      Kunimoto Y, Nakano S, Kataoka H, Shimada Y, Oshimmura M, Kitano H
    • Journal Title

      ORL J Otorhinolarygol Relat Spec

      Volume: 73 Pages: 17-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deleted in Esophageal Cancer 1 (DEC1) is down regulated and contributes to migration in HNSCC cell lines.2010

    • Author(s)
      Kunimoto Y, Nakano S, Kataoka H, Shimada Y, Oshimura M, Kitano H.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec. 73

      Pages: 17-23

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allele-Specific Expression Analysis of PEG1/MEST in Head and Neck Squamous Cell Carcinomas.2010

    • Author(s)
      H.Kataoka, et al
    • Journal Title

      Yonago Acta Medica 52

      Pages: 85-90

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Geminin deletion in hematopoietic stem cells promotes differentiation of megakaryocytes and platelets.2011

    • Author(s)
      Seiji Nakano, Yousuke Sasaki, HozumiMotohashi, Keiko Nakayama.
    • Organizer
      Winter Camp of GCOE 2011
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] Gemininは造血幹細胞の維持と巨核球の分化を制御する2010

    • Author(s)
      中野星児, et al
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Geminin deletion in hematopoietic stem cells promotes differentiaton of megakaryocytes and platelets2010

    • Author(s)
      中野星児、佐々木陽丞、本橋ほづみ、中山啓子
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] T-cell differentiation and proliferation in Geminin genedeleted mouse2009

    • Author(s)
      中野星児, et al
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chromobox homologue 3 is a essential modulator of endodermal and mesodermal differentiation in F9 cells2009

    • Author(s)
      池田信人, et al
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Defect of T-cell differentiation and proliferation in Geminin gene-deleted mouse.2009

    • Author(s)
      中野星児、山田秀俊、村井寛子、佐竹正延、中山啓子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Chromobox homologue 3 is a essential modulator of endodermal and mesodermal differentiation in F9 cells.2009

    • Author(s)
      池田信人、森川久未、中野星児、久留一郎、白吉安昭
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Defect of T-cell differentiation and proliferation in Geminin gene-deleted mouse.2009

    • Author(s)
      Seiji Nakano, Hidetoshi Yamada, Hiroko Murai, Masanobu Satake, Keiko Nakayama.
    • Organizer
      東北大学グローバルCOE NetworkMedcine創生拠点国際シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 東北大学医学系研究科細胞増殖制御分野

    • URL

      http://www.devgen.med.tohoku.ac.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.devgen.med.tohoku.ac.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.devgen.med.tohoku.ac.jp/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi