Inhibitory Effects of Epigallocatechin-3 Gallate, a catechin in Green Tea, on Tumor-Associated Endothelial Cells
| Project/Area Number |
21890006
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHGA Noritaka Hokkaido University, 大学院・歯学研究科, 特任助教 (40548202)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥975,000 (Direct Cost: ¥750,000、Indirect Cost: ¥225,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
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| Keywords | 緑茶カテキン / 腫瘍血管新生 / 血管内皮前駆細胞 / 血管新生阻害薬 |
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| Research Abstract |
The epigallocatechin-3 gallate (EGCG) in green tea suppresses tumor growth, but it is not known whether it specifically inhibits tumor angiogenesis. We examined the anti-angiogenic effect of EGCG on tumor-associated endothelial cells (TECs), EPCs, and normal endothelial cells (NECs). TECs were isolated and cultured from human tumor xenografts in nude mice. EGCG suppressed the migration of TECs and EPCs. EGCG also inhibited the phosphorylation of Akt in EPCs. MMP-9 in the bone marrow is involved in mobilizing bone marrow-derived VEGFR-2 positive cells into peripheral circulation. Expression of MMP-9 mRNA was suppressed in bone marrow stromal cells by EGCG. In vivo model, EGCG reduced melanoma growth. Our study showed that EGCG has anti-angiogenic effects. EGCG is a promising angiogenesis inhibitor for cancer therapy.
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Report
(2 results)
Research Products
(30 results)
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[Journal Article] HuR keeps an angiogenic switch on by stabilizing mRNA of VEGF and COX-2 in tumor endothelium2011
Author(s)
Kurosu T., Ohga N., Hida Y., Maishi N., Akiyama K., Kakuguchi W., Kuroshima T., Kondo M., Akino T., Totsuka Y., Shindoh M., Higashino F., Hida K.
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Journal Title
Br J Cancer 104(5)
Pages: 819-829
Related Report
Peer Reviewed
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[Journal Article] Isolated tumor endothelial cells maintain specific character during long-term culture2010
Author(s)
Matsuda K., Ohga N., Hida Y., Muraki C., Kurosu T., Tsuchiya K., Akino T., Shih SC, Totsuka Y., Klagsbrun M., Shindoh M., Hida K.
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Journal Title
Biochem Biophys Res Commun 394
Pages: 947-954
Related Report
Peer Reviewed
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[Journal Article] Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization2010
Author(s)
Tsuchiya K., Hida K., Hida Y., Muraki C., Ohga N., Kondo T., Miseki T., Nakagawa K, Shindoh M., Harabayashi T., Shinohara N,, Nonomura K., Kobayashi M.
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Journal Title
Int J Oncol 36(6)
Pages: 1379-1386
NAID
Related Report
Peer Reviewed
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[Journal Article] Inhibitory Effects of Epigallocatechin-3 Gallate, a Polyphenol in Green Tea, on Tumor-Associated Endothelial Cells and Endothelial Progenitor Cells.2009
Author(s)
Ohga N., Hida K., Hida Y., Muraki C., Tsuchiya K., Matsuda K., Ohiro Y., Totsuka Y., Shindoh M.
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Journal Title
Cancer Sci 100(10)
Pages: 1963-1970
NAID
Related Report
Peer Reviewed
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