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Systematic analysis of megakaryopoiesis and platelet production by using genetically modified mice.

Research Project

Project/Area Number 21890024
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionUniversity of Tsukuba

Principal Investigator

KOZUMA Yukinori  University of Tsukuba, 大学院・人間総合科学研究科, 助教 (90550145)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Keywords巨核球 / 血小板 / Bim / apoptosis / 細胞周期
Research Abstract

To elucidate whether Bim and CD226 are involved in megakaryopoiesis and platelet function, we characterized megakaryocytes and platelets in bim knockout (KO) mice and CD226 KO mice. We have demonstrated the dual role of Bim during megakaryopiesis, namely the control of apoptotsis and cell cycle progression. We have suggested that CD226 is involved in platelet production and platelet function.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria.2011

    • Author(s)
      Kozuma Y, Sawahata Y, Takei Y, Chiba S, Ninomiya H.
    • Journal Title

      Br J Haematol. vol.152

      Pages: 631-639

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria.2011

    • Author(s)
      Yukinori Kozuma
    • Journal Title

      British Journal of Haematology

      Volume: VOL.152 Pages: 631-639

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (ショ糖水)試験,Ham試験2010

    • Author(s)
      上妻行則、二宮治彦,砂糖水
    • Journal Title

      Medicina 47巻

      Pages: 60-62

    • Related Report
      2010 Final Research Report
  • [Journal Article] The pro-apoptotic BH3-only protein Bim regulates cell cycle progression of hematopoietic progenitors during megakaryopoiesis.2010

    • Author(s)
      Kozuma Y, Ninomiya H, Murata S, Kono T, Mukai HY, Kojima H.
    • Journal Title

      J Thromb Haemost. vol.8

      Pages: 1088-97

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 貧血の検査法b)溶血に関する検査2010

    • Author(s)
      上妻行則、二宮治彦
    • Journal Title

      血液診療エキスパート貧血

      Pages: 48-53

    • Related Report
      2010 Final Research Report
  • [Journal Article] Enhanced expression of CD71, transferrin receptor, on immature reticulocytes in patientswith paroxysmal nocturnal hemoglobinuria.2010

    • Author(s)
      Sato S, Kozuma Y, Hasegawa Y, Kojima H, Chiba S, Ninomiya H.
    • Journal Title

      Int J Lab Hematol. 32(1 Pt 1)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 巨核球分化におけるカスパーゼ活性化の意義2010

    • Author(s)
      上妻行則、小島寛
    • Journal Title

      血液・腫瘍科 60

      Pages: 192-199

    • NAID

      40019064705

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ham試験ほか,PNHに関する血液検査2010

    • Author(s)
      上妻行則、二宮治彦
    • Journal Title

      日本臨床(広範囲血液・尿化学検査免疫学的検査) 増刊号 68巻

      Pages: 629-631

    • Related Report
      2010 Final Research Report
  • [Journal Article] The pro-apoptotic BH-3-only protein Bim regulates cell cycle progression of hematopoietic progenitors during megakaryopoiesis2010

    • Author(s)
      Yukinori Kozuma
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: VOL.8 Pages: 1088-1097

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 砂糖水(ショ糖水)試験,Ham試験2010

    • Author(s)
      上妻行則
    • Journal Title

      Medicina

      Volume: VOL.47 Pages: 60-62

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 貧血の検査法b)溶血に関する検査2010

    • Author(s)
      上妻行則
    • Journal Title

      血液診療エキスパート貧血

      Pages: 48-53

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The pro-apoptotic BH-3-only protein Bim regulates cell cycle progression of hematopoietic progenitors during megakaryopoiesis2010

    • Author(s)
      Yukinori Kozuma
    • Journal Title

      Journal of Thrombosis and Haemostasis (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ham試験ほか,PNHに関する血液検査2010

    • Author(s)
      上妻行則
    • Journal Title

      日本臨床 増刊 広範囲 血液・尿化学検査 免疫学的検査 68

      Pages: 629-631

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 巨核球分化におけるカスパーゼ活性化の意義2010

    • Author(s)
      上妻行則
    • Journal Title

      血液・腫瘍科 60(2)

      Pages: 192-199

    • NAID

      40019064705

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 発作性夜間血色素尿症(PNH)診断のためのCD55,CD59検査2009

    • Author(s)
      上妻行則、二宮治彦
    • Journal Title

      診断と治療 97巻

      Pages: 1924-1926

    • Related Report
      2010 Final Research Report
  • [Journal Article] 発作性夜間ヘモグロビン尿症(PNH)診断のためのCD55,CD59検査2009

    • Author(s)
      上妻行則
    • Journal Title

      診断と治療 97(9)

      Pages: 1924-1926

    • Related Report
      2009 Annual Research Report
  • [Presentation] 巨核球造血における細胞間接着因子CD226(DNAM-1)の役割2010

    • Author(s)
      上妻行則
    • Organizer
      第33回日本血栓止血学会学術集会
    • Place of Presentation
      城山観光ホテル(鹿児島県)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 巨核球造血における細胞間接着因子CD226(DNAM-1)の役割2010

    • Author(s)
      上妻行則
    • Organizer
      日本血栓止血学会学術集会
    • Place of Presentation
      城山観光ホテル(鹿児島県)
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 巨核球造血におけるapoptosis関連タンパクの役割2009

    • Author(s)
      上妻行則
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 巨核球造血におけるapoptosis関連タンパクの役割2009

    • Author(s)
      上妻行則
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] C-MybとCD9による新たな巨核球造血制御機構2009

    • Author(s)
      向井陽美
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] c-MybとCD9による新たな巨核球造血制御機構2009

    • Author(s)
      向井陽美
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 巨核球造血・血1小板産生に対する抗血1小板抗体の影響2009

    • Author(s)
      上妻行則
    • Organizer
      第32回日本血栓止血学会学術集会
    • Place of Presentation
      リーガロイヤルホテル小倉・北九州国際会議場(福岡県)
    • Year and Date
      2009-06-06
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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