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Analysis of the role of Notch signal of NK cell in hematopoietic stem cell transplantation

Research Project

Project/Area Number 21890027
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionUniversity of Tsukuba

Principal Investigator

KURITA Naoki  University of Tsukuba, 附属病院, 病院講師 (30555561)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
KeywordsNotch1 / GVHD / NK細胞 / 造血幹細胞移植 / 移植片対宿主病 / Notchシグナル
Research Abstract

The purpose of our study is to clarify roles of Notch signal of NK cell in graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation. Functionally mature NK cells were induced from human cord-blood CD34-positive cells by stimulation with Notch ligand. We established allogeneic stem cell transplantation GVHD model. Diminishment of GVHD was observed when Notch-induced NK cells were transfused into the recipient. It is revealed that NK cells of patients after hematopoietic stem-cell transplantation expressed Notch1 and intestinal epithelial cells, which are targets of GVHD, expressed Notch ligand, Jagged1. This result suggests the relation between Notch signal of NK cell and GVHD.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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