|Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Intraoral digestion triggers various biological responses via taste sensation and/or nutrient absorption at upper intestine. Nevertheless, the effect of sweet sensation on the regulation of glucose metabolism remains unknown. We measured GLP-1 secretion in response to test meal ingestion in Japanese male volunteers. Unexpectedly, GLP-1 secretion occurred synchronously with blood glucose rise and non-nutritive sweetener failed to trigger GLP-1 secretion. Therefore, the early GLP-1 secretion requires the direct stimulation with nutrients in the gut rather than the sweet sensation on the tongue.