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Evaluation of molecular mechanisms of tumor-specific protoporphyr in accumulation induced by 5-aminolevulinic acid

Research Project

Project/Area Number 21890084
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKanazawa University

Principal Investigator

NAKANISHI Takeo  Kanazawa University, 薬学系, 准教授 (30541742)

Co-Investigator(Renkei-kenkyūsha) TAMAI Ikumi  金沢大学, 薬学系, 教授 (20155237)
SHIRASAKA Yoshiyuki  金沢大学, 薬学系, 助教 (60453833)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywordsトランスポーター / アミノレブリン酸 / プロトポルフィリン / 化学療法 / フェロキラターゼ / 光力学療法 / 有機アニオン / プロトポルフォリン / 薬物排泄 / 光力学診断 / 蛍光診断
Research Abstract

5-Aminolevulinic acid is one of the most potent photodynamic therapeutic agents, because it induces tumor cell-specific intracellular accumulation of a photosensitizer, protoporphyrin IX (PPIX). However, molecular mechanisms of such 5-ALA-induced PPIX accumulation remain unclear. In the current study, in order to establish a basis to predict efficacy of photodynamic therapy to treat cancer, molecular mechanisms of intracellular accumulation of PPIX induced by 5-ALA were studied in various human cancer cell lines exposed to 5-ALA. Results suggested that PPIX accumulation is likely determined by PPIX biosynthesis, ferrochelatase (FECH) activity and PPIX efflux.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (2 results)

All 2010

All Presentation (2 results)

  • [Presentation] ヒト癌細胞株におけるOAT2を介した光線力学療法薬5-アミノレブリン酸の細胞膜輸送2010

    • Author(s)
      小川哲郎、中西猛夫、白坂善之、松井裕史、玉井郁巳
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんホール徳島県強度文化会館(徳島市、徳島)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト癌細胞株におけるOAT2を介した光線力学療法薬5-アミノレブリン酸の細胞膜輸送2010

    • Author(s)
      小川哲郎
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんホール徳島県郷上文化会館(徳島)
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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