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Innovation of the novel cardiac regeneration therapy using gene introduction-mediated cell conversion into cardiac progenitor cells.

Research Project

Project/Area Number 21890117
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKyoto University

Principal Investigator

KAWAMURA Teruhisa  Kyoto University, 生命科学系キャリアバス形成ユニット, 助教 (90393199)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
Keywords分子心臓病態学 / 再生医学 / 幹細胞生物学 / 体細胞初期化
Research Abstract

Recent technologies to reprogram somatic cells into induced pluripotent stem (iPS) cells have been expected as a powerful tool of regeneration therapy for end-staged heart failure. However, duration of iPS cell derivation and the risk of tumorigenesis including teratoma after cell implantation as well as limited efficiency for cardiac differentiation are considered as great barriers against the clinical application of this powerful approach. To overcome these problems, by modifying the reprograming process, here we show the novel alternative strategy which enables us to create cardiac myocytes directly from fibroblasts rapidly and efficiently with a low risk of tumorigenesis. In addition, we established the mouse experimental model to evaluate the effect of this strategy as an innovative cardiac regeneration therapy.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (11 results) Book (1 results) Remarks (3 results)

  • [Journal Article] MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor betal in neonatal rat ventricular myocytes.2011

    • Author(s)
      Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, Kimura T.
    • Journal Title

      Mol Cell Biol. 31

      Pages: 744-755

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes.2011

    • Author(s)
      Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K.
    • Journal Title

      J Cell Physiol. 226

      Pages: 248-254

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-27a regulates beta cardiac myosin heavy chain gene expression by targeting thyroid hormone receptor beta1, in neonatal rat ventricular myocytes.2011

    • Author(s)
      Nishi H, Ono K, Horie T, Nagao K, Kinoshita M, Kuwabara Y, Watanabe S, Takaya T, Tamaki Y, Takanabe-Mori R, Wada H, Hasegawa K, Iwanaga Y, Kawamura T, Kita T, Kimura T.
    • Journal Title

      Mol Cell Biol.

      Volume: 31 Pages: 744-755

    • NAID

      120002871162

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes.2011

    • Author(s)
      Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K.
    • Journal Title

      J Cell Physiol.

      Volume: 226 Pages: 248-254

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.2010

    • Author(s)
      Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.
    • Journal Title

      Cardiovasc Res. 88

      Pages: 314-323

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human and mouse adipose-derived cells support feeder independent induction of pluripotent stem cells.2010

    • Author(s)
      Sugii S, Kida Y, Kawamura T, Suzuki J, Vassena R, Yin YQ, Lutz MK, Berggren WT, Izpisua-Belmonte JC, Evans RM.
    • Journal Title

      Proc Natl Acad Sci USA. 107

      Pages: 3558-3563

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.2010

    • Author(s)
      Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.
    • Journal Title

      Cardiovasc Res.

      Volume: 88 Pages: 314-323

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human and mouse adipose-derived cells support feeder independent induction of pluripotent stem cells.2010

    • Author(s)
      Sugii S, Kida Y, Kawamura T, et al.
    • Journal Title

      Proc Natl Acad Sci USA. 107

      Pages: 3558-3563

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linking the p53 tumour suppressor pathway to somatic cell reprogramming.2009

    • Author(s)
      Kawamura T, Suzuki J, Wang YV, Menendez S, Batlle Morera L, Raya A, Wahl GM, Izpisua-Belmonte JC.
    • Journal Title

      Nature. 460

      Pages: 1140-1144

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells.2009

    • Author(s)
      Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K.
    • Journal Title

      Circ J. 73

      Pages: 1492-1497

    • NAID

      10025933876

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Linking the p53 tumour suppressor pathway to somatic cell reprogramming.2009

    • Author(s)
      Kawamura T, 筆頭著者, et al.
    • Journal Title

      Nature 460

      Pages: 1140-1144

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells.2009

    • Author(s)
      Takaya T, Ono K, Kawamura T, et al.
    • Journal Title

      Circ J. 73

      Pages: 1492-1497

    • NAID

      10025933876

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] iPS細胞誘導過程における細胞運命決定機構を探る2010

    • Author(s)
      川村晃久
    • Organizer
      CKDと心血管イベントExpert Meeting V
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Efficient creation of induced pluripotent stem cells for myocardial regeneration therapy.2010

    • Author(s)
      Sogo T, Takaya T, Shigeno A, Kojima Y, Hasegawa K, Kawamura T.
    • Organizer
      2010 World Heart Federation
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-06-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Efficient creation of induced pluripotent stem cells for myocardial regeneration therapy.2010

    • Author(s)
      Sogo T, Takaya T, Shigeno A, Kojima Y, Hasegawa K, Kawamura T.
    • Organizer
      World Heart Federation
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Wnt signaling in cardiac differentiation from mouse embryonic stem cells and induced pluripotent stem cells.2010

    • Author(s)
      Shigeno A, Sogo T, Takaya T, Kojima Y, Hasegawa K, Kawamura T.
    • Organizer
      2010 World Heart Federation
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of Wnt signaling in cardiac differentiation from mouse embryonic stem cells and induced pluripotent stem cells.2010

    • Author(s)
      Shigeno A, Sogo T, Takaya T, Kojima Y, Hasegawa K, Kawamura T.
    • Organizer
      World Heart Federation
    • Place of Presentation
      Beijing, China
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] p53 tumor suppressor pathway as a novel checkpoint during somatic cell reprogramming.2010

    • Author(s)
      Kawamura T, Suzuki J.
    • Organizer
      第9回再生医療学会
    • Place of Presentation
      広島(招待シンポジスト)
    • Year and Date
      2010-03-18
    • Related Report
      2010 Final Research Report
  • [Presentation] p53 tumor suppressor pathway as a novel checkpoint during somatic cell reprogramming.2010

    • Author(s)
      Kawamura T, Suzuki J
    • Organizer
      第9回再生医療学会(招待シンポジウト)
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Links between p53 tumor suppressor pathway and somatic cell reprogramming.2009

    • Author(s)
      Kawamura T, Jotaro Suzuki J, Wahl GM, Izpisua-Belmonte JC.
    • Organizer
      第32回分子生物学会年会(ワークショップ)
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Links between p53 tumor suppressor pathway and somatic cell reprogramming.2009

    • Author(s)
      Kawamura T, Suzuki J, Wahl GM, Izpisua-Belmonte JC.
    • Organizer
      第32回分子生物学会年会(ワークショップ口頭発表)
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] The p53 pathway as a guardian against reprogramming.2009

    • Author(s)
      川村晃久
    • Organizer
      The 5th China-Japan Cardiovascular Forum
    • Place of Presentation
      Beijing, China(招待講演)
    • Year and Date
      2009-10-12
    • Related Report
      2010 Final Research Report
  • [Presentation] The p53 pathway as a guardian against reprogramming2009

    • Author(s)
      Kawamura T.
    • Organizer
      The 5^<th> China-Japan Cardiovascular Forum(招待講演)
    • Place of Presentation
      北京(中国)
    • Year and Date
      2009-10-12
    • Related Report
      2009 Annual Research Report
  • [Book] アンチ・エイジング医学-日本抗加齢医学会雑誌2011

    • Author(s)
      川村晃久、十河孝浩
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.cp.kyoto-u.ac.jp/Kawamura/KawamuraIndex.html

    • Related Report
      2010 Final Research Report
  • [Remarks] 研究室ホームページ

    • Related Report
      2010 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.cp.kyoto-u.ac.jp/Kawamura/KawamuraIndex.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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