Comprehensive diagnosis system for colon cancer using metagenome and metabolomics
Project/Area Number |
21890138
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
|
Research Institution | Kobe University |
Principal Investigator |
YOSHIDA Shiei Kobe University, 医学部附属病院, 医員 (30514955)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
Keywords | 大腸がん / メタボロミクス / メタゲノム / メタボローム解析 / 質量分析計 |
Research Abstract |
It has been recognized that the incidence of colorectal cancer is recently increasing due to changes in intestinal flora by dietary habits of the Western-style food. Therefore, we considered that the information about colorectal cancer integrated in the intestinal flora and the analysis of intestinal flora is urgent. In this study, the genetic information of the intestinal flora was investigated using a stool of patients with colorectal cancer (metagenomic analysis) and furthermore the variation of metabolites in the intestinal flora (metabolomic analysis) was examined. Based on the results obtained from metagenomic analysis and metabolomic analysis, we tried to develop the novel early diagnostic method for colorectal cancer.
|
Report
(3 results)
Research Products
(6 results)
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[Journal Article] Predictors of malignant intraductal papillary mucinous neoplasm of the pancreas.2010
Author(s)
Mimura T, Masuda A, Matsumoto I, Shiomi H, Yoshida S, Sugimoto M, Sanuki T, Yoshida M, Fujita T, Kutsumi H, Ku Y, Azuma T.
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Journal Title
J Clin Gastroenterol 44(9)
Pages: 224-229
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Author(s)
吉田志栄, 久津見弘, 船津英司, 佐貫毅, 塩見英之, 信谷健太郎, 増田充弘, 森田圭紀, 矢野嘉彦, 吉田優, 瀬尾靖, 豊永高史, 井口秀人, 東健
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[Presentation] 平成21年9月胆道学会:胆道再建術後症例に対する内視鏡的胆道関連手技についての検討2009
Author(s)
吉田志栄, 久津見弘, 杉本真樹, 小畑大輔, 古松恵介, 吉中勇人, 塩見英之, 信谷健太郎, 増田充弘, 佐貫毅, 具英成, 東健
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[Presentation] 平成21年10月J-DDW:当院におけるERCP後膵炎の現状とその対策2009
Author(s)
吉田志栄, 久津見弘, 佐貫毅, 塩見英之, 信谷健太郎, 増田充弘, 森田圭紀, 矢野嘉彦, 吉田優, 瀬尾靖, 豊永高史, 井口秀人, 東健
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