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Elucidation of inhibition mechanism of ameloblastoma growth・ differentiation by Sprouty regulating MAPK cascade.

Research Project

Project/Area Number 21890185
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKyushu University

Principal Investigator

TAKETOMI Takaharu  Kyushu University, 大学院・歯学研究院, 助教 (10553290)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
KeywordsMAPK / Sprouty / EGF / FGF 刺激 / エナメル上皮腫 / MAPK経路 / Sprouty2 / FGFシグナル / EGFシグナル
Research Abstract

expression were enhanced by EGF stimulation. Spry2 induced by Ras-ERK signal cascade was negative regulator for ERK activation by FGF signaling, but accelerated it by EGF signaling in AM-1 cells. Spry2 might be associated with the growth of ameloblastoma through the promotion of EGF signaling.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (14 results) Remarks (2 results)

  • [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling.2011

    • Author(s)
      Matsumura K, Taketomi T, Yoshizaki K, Arai S, Sanui T, Yoshiga D, Yoshimura A, Nakamura S.
    • Journal Title

      Biochem Biophys Res Commun. Volume 404, Issue 4

      Pages: 1076-1082

    • Related Report
      2010 Final Research Report
  • [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling2011

    • Author(s)
      Matsumura K, et at.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 404 Pages: 1076-1082

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate.2010

    • Author(s)
      K.Matsumura, T.Taketomi, K.Yoshizaki, D.Yoshiga, T.Maehara, S.Arai, T.Sanui, A.Yoshimura, S.Nakamura.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] RNF135, a RING finger protein, negatively regulates RAS/MAPK signaling.2010

    • Author(s)
      D.Yoshiga, T.Taketomi, D.Muratsu, T.Onimura, H.Shiraishi, T.Sanada, T.Kobayashi, S.Nakamura.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Suppression of Sprouty2 Induces Periodontal Tissue Regeneration.2010

    • Author(s)
      T.Sanui, T.Fukuda, T.Taketomi, T.Hamachi, K.Maeda.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] RNF135, a RING finger protein, negatively regulates RAS/MAPK signaling.2010

    • Author(s)
      D.Yoshiga, et al.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Place of Presentation
      Spain
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] YB-1 is important for amelogenin induced periodontal regeneration.2010

    • Author(s)
      T.Fukuda, et al.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Place of Presentation
      Spain
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate.2010

    • Author(s)
      K.Matsumura, et al.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Place of Presentation
      Spain
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sprouty2 accelerates the growth of ameloblastoma with EGF stimulation.2010

    • Author(s)
      Takaharu Taketomi, Daigo yoshiga, Kaori matsumura, Takeshi Mitsuyasu, Terukazu Sanui, Takao Fukuda, Akihiko Yoshimura, Seiji Nakamura.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Year and Date
      2010-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Sprouty2 accelerates the growth of ameloblastoma with EGF stimulation.2010

    • Author(s)
      Takaharu Taketomi, et al.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Place of Presentation
      Spain
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of Sprouty2 Induces Periodontal Tissue Regeneration.2010

    • Author(s)
      T.Sanui, et al.
    • Organizer
      88th General Session and Exhibition of the IADR
    • Place of Presentation
      Spain
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate.2010

    • Author(s)
      Kaori Matsumura, Takaharu taketomi, Masaaki Sasaguri, Takeshi Mitsuyasu, Tomomi Tsujiguchi, Shinsaku Arai, Daigo Yoshiga, Terukazu Sanui, Akihiko Yoshimura, Seiji Nakamura.
    • Organizer
      The 6th Congress of International Cleft Palate Foundation in Conjunction with 14th national Congress of Korean Cleft Lip and Palate Association
    • Year and Date
      2010-06-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Sprouty2 Deficient Mice Exhibit Cleft Palate.2010

    • Author(s)
      Matsumura K, et al.
    • Organizer
      The 6th Congress of International Cleft Palate Foundation in Conjunction with 14th national Congress of Korean Cleft Lip and Palate Association
    • Place of Presentation
      Korea
    • Year and Date
      2010-06-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of the molecular mechanisms of periodontal regeneration by EMD.2010

    • Author(s)
      Takao Fukuda, Terukazu Sanui, Takaharu Taketomi, Takafumi Hamachi, Katsumasa Maeda.
    • Organizer
      The 5th International Symposum on Dental and Craniofacial Morphogenesis and Tissue Regeneration : A View from Stem Cell Research
    • Year and Date
      2010-02-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Analysis of the novel protein bound to amelogenin in periodontal tissue cells2009

    • Author(s)
      福田隆男
    • Organizer
      The 11^<th> KSCD-JSCD joint meeting
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯周組織細胞群における新規アメロジェニン結合タンパク質の検索2009

    • Author(s)
      福田隆男
    • Organizer
      第52回日本歯周病学会春期学術大会
    • Place of Presentation
      岡山、日本
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/index.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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