functional analysis of GslA that newly identified of P.gingivalis
| Project/Area Number |
21890195
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
HARUYAMA Koki Nagasaki University, 大学病院, 医員 (40549466)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
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| Keywords | P. gingivalis / gingipain / 自然免疫 / P.gingivalis / 刺激伝達経路 / GslA |
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| Research Abstract |
We previously purified and identified the protein from cell surface component on P. gingivalis, a major periodontal pathogen. This protein was able to induce Toll-like receptor 2 (TLR2)- and TLR4-independent signaling in CHO cells and that this component can be degraded by gingipains. Therefore, we named the protein as gingipain-sensitive ligand A (GslA). P. gingivalis gingipain-null mutant was partially inhibited by antiserum against a recombinant protein expressed from the first one third of gslA. Furthermore, the gslA gene was present in four of seven P. gingivalis strains tested.
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Report
(3 results)
Research Products
(4 results)
