The development of novel cancer-immunotherapy utilizing dendritic cells derived from iPS cells.
Project/Area Number |
21890199
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Dermatology
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Research Institution | Kumamoto University |
Principal Investigator |
FUKUSHIMA Satoshi Kumamoto University, 医学部附属病院, 助教 (50398210)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
Keywords | iPS細胞 / 樹状細胞 / 癌免疫療法 / 多能性幹細胞 / 免疫療法 / がん抗原 / IL-15 / 悪性黒色腫 / 腫瘍マーカー / メラノーマ / 腫瘍免疫 |
Research Abstract |
To develop the novel cell-vaccine against the advanced malignant melanoma, we conducted the experiments using the genetically modified iPS cell derived dendritic cells. We found that the dendritic cells could be generated from any clones of mouse iPS cells. We found that KIF20A is highly expressed in malignant melanoma. In addition, we found that micro RNA-221 could be a new tumor marker of malignant melanoama.
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Report
(3 results)
Research Products
(52 results)
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[Journal Article] The circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker.2011
Author(s)
Kanemaru H, Fukushima S, Yamashita J, Honda N, Oyama R, Kakimoto A, Masuguchi S, Ishihara T, Inoue Y, Jinnin M, Ihn H.
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Journal Title
J Dermatol Sci. 61巻
Pages: 187-193
NAID
Related Report
Peer Reviewed
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[Journal Article] Circulating microRNA associated with TNF-α signaling pathway in patients with plaque psoriasis.2011
Author(s)
Oyama R, Jinnin M, Kakimoto A, Kanemaru H, Ichihara A, Fujisawa A, Honda N, Masuguchi S, Fukushima S, Maruo K, Ihn H.
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Journal Title
J Dermatol Sci. 61巻
Pages: 209-211
NAID
Related Report
Peer Reviewed
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[Journal Article] Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis.2010
Author(s)
Higashi-Kuwata N, Jinnin M, Makino T, Fukushima S, Inoue Y, Muchemwa FC, Yonemura Y, Komohara Y, Takeya M, Mitsuya H, Ihn H.
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Peer Reviewed
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[Journal Article] ES細胞2009
Author(s)
福島聡, 西村泰治, 千住覚
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Journal Title
iPS細胞由来の樹状細胞を利用したワクチン臨床免疫・アレルギー科 52巻
Pages: 331-338
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