Exploitation of tissue specific proton pump inhibitors
Project/Area Number |
21890239
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
|
Research Institution | Iwate Medical University |
Principal Investigator |
SEKIYA Mizuki Iwate Medical University, 薬学部, 助教 (70509033)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
|
Keywords | 酵素 / プロトンATPase / V-ATPase / ATP合成酵素 / 阻害剤 |
Research Abstract |
I analyzed rotation mechanism of F-type ATPase using single molecule observation system in order to understand those of proton ATPases including V-type ATPase in osteoclast. Thermodynamic analysis of the rotation indicated that a specific γ-β interaction in F1 sector is important for flat energy pathway during the rotation, and F1 requires ~2-fold higher activation energy for the transition from the active state (continuous rotation) to the inhibited state (~1 sec pausing) compared with that for normal steady-state rotation during the active state.
|
Report
(3 results)
Research Products
(33 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 大腸菌ATP合成酵素におけるεサブユニットの役割2010
Author(s)
関谷瑞樹, 中西(松井)真弓, 西山枝里, Robert K., Nakamoto, Marwan K., Al-Shawi, 二井將光
Organizer
日本薬学会第131年会
Place of Presentation
静岡(東日本大震災のため中止)
Year and Date
2010-03-30
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-