Elucidation of physiological role of the bone formation potentiator contained in platelet.
Project/Area Number |
21890243
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | Saitama Medical University |
Principal Investigator |
OHTE Satoshi Saitama Medical University, 医学部, 助教 (00547979)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥2,587,000 (Direct Cost: ¥1,990,000、Indirect Cost: ¥597,000)
Fiscal Year 2010: ¥1,222,000 (Direct Cost: ¥940,000、Indirect Cost: ¥282,000)
Fiscal Year 2009: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
Keywords | 骨代謝 / 血小板 / Bone morphogenetic protein / Smad / 骨形成 / タンパク質 / 細胞・組織 / 骨芽細胞 |
Research Abstract |
The aim of this study is to elucidate the physiological role of the bone formation potentiator contained in platelet. As a result, it became clear that this protein increase the activity of bone morphogenetic protein (BMP), which is the cytokine induce ectopic bone formation in muscular tissue, in vitro and in vivo. Our findings suggest that this protein will become new medicine of bone formation.
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Report
(3 results)
Research Products
(37 results)
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[Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H2011
Author(s)
Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Namba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T, Katagiri T
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Journal Title
Biochem Biophys Res Commun. 407
Pages: 213-218
Related Report
Peer Reviewed
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[Journal Article] Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.2011
Author(s)
Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, Nojima J, Ono Y, Yoda T, Fukuda T, Katagiri T
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Journal Title
Mol Endocrinol. 25
Pages: 474-481
Related Report
Peer Reviewed
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[Journal Article] Dual roles of smad proteins in the conversion from myoblasts to osteoblastic cells by bone morphogenetic proteins.2010
Author(s)
Nojima J, Kanomata K, Takada Y, Fukuda T, Kokabu S, Ohte S, Takada T, Tsukui T, Yamamoto TS, Sasanuma H, Yoneyama K, Ueno N, Okazaki Y, Kamijo R, Yoda T, Katagiri T
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Journal Title
J Biol Chem 285
Pages: 15577-15586
Related Report
Peer Reviewed
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[Presentation] Identification of Zranb2, a novel R-Smads binding protein, as a suppressor of BMP signaling.2010
Author(s)
Satoshi Ohte, Shoichiro Kokabu, Toru Fukuda,, Shunichiro Iemura, Hiroki Sasanuma, Katsumi Yoneyama, Masashi Shin, Eijiro Jimi, Toru Natsume, Takenobu Katagiri
Organizer
2010 ASBMR Annual Meeting
Place of Presentation
トロント(カナダ)
Year and Date
2010-10-17
Related Report
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