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Search for natural products targeting Pokemon signaling pathway

Research Project

Project/Area Number 21890268
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Drug development chemistry
Research InstitutionHoshi University

Principal Investigator

HOYOYA Takahiro  Hoshi University, 薬学部, 研究員 (30506572)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,483,000 (Direct Cost: ¥1,910,000、Indirect Cost: ¥573,000)
Fiscal Year 2010: ¥1,092,000 (Direct Cost: ¥840,000、Indirect Cost: ¥252,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
Keywords天然物 / ポケモン / 肺がん / スクリーニング / シグナル伝達 / 転写因子 / がん
Research Abstract

Pokemon (POK erythroid myeloid ontogenic factor ; LRF, FBI1, ZBTB7A) is a transcriptional suppressor. It is reported that the overexpression of Pokemon in lung cancer cell caused oncogenesis or maintain of the cancer. To search for inhibitors of the Pokemon signaling pathway, new cell-based assay systems were developed and screening of natural product or natural resources have been performed.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Inhibitors of Nitric Oxide Production from Stemona javanica.2011

    • Author(s)
      Hosoya, Takahiro; Yamasaki, Fumie; Nakata, Asami; Rahman, Abdul; Kusumawati, Idha; Zaini, Noor Cholies; Morita, Hiroshi
    • Journal Title

      Planta Medica 77

      Pages: 256-258

    • Related Report
      2010 Final Research Report
  • [Journal Article] Inhibitors of nitric oxide production from Stemona javanica2011

    • Author(s)
      Hosoya T, Yamasaki F, Nakata A, Rahman A, Kusumawati I, Zaini NC, Morita H
    • Journal Title

      Planta Med

      Volume: 77(3) Pages: 256-258

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Papuabalanols A and B, new tannins from Balanophora papuana.2010

    • Author(s)
      Hosoya, Takahiro; Nakata, Asami; Zaima, Kazumasa; Latip, Jalifah; Din, Laily Bin; Muslim, Noramly; Morita, Hiroshi
    • Journal Title

      Chemical & Pharmaceutical Bulletin 58

      Pages: 738-741

    • Related Report
      2010 Final Research Report
  • [Journal Article] Papuabalanols A and B, New Tannins from Balanophora papuana2010

    • Author(s)
      Takahiro HOSOYA, Asami NAKATA, Kazumasa ZAIMA, Jalifah LATIP, Laily Bin DIN, Noramly MUSLIM, Hiroshi MORITA
    • Journal Title

      Chemical and Pharmaceutical Bulletin 58(5)

      Pages: 738-741

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ツチトリモチ科Balanophora papanaの成分に関する研究2010

    • Author(s)
      細谷孝博、森田博史、Noramly Muslim、Laily Din
    • Organizer
      第56回日本生薬学会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] ツチトリモチ科Balanophora papuanaの成分に関する研究2009

    • Author(s)
      細谷孝博
    • Organizer
      日本生薬学会 第56年会
    • Place of Presentation
      京都薬科大学(京都)
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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