Search for natural products targeting Pokemon signaling pathway
| Project/Area Number |
21890268
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Hoshi University |
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Principal Investigator |
HOYOYA Takahiro Hoshi University, 薬学部, 研究員 (30506572)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,483,000 (Direct Cost: ¥1,910,000、Indirect Cost: ¥573,000)
Fiscal Year 2010: ¥1,092,000 (Direct Cost: ¥840,000、Indirect Cost: ¥252,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 天然物 / ポケモン / 肺がん / スクリーニング / シグナル伝達 / 転写因子 / がん |
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| Research Abstract |
Pokemon (POK erythroid myeloid ontogenic factor ; LRF, FBI1, ZBTB7A) is a transcriptional suppressor. It is reported that the overexpression of Pokemon in lung cancer cell caused oncogenesis or maintain of the cancer. To search for inhibitors of the Pokemon signaling pathway, new cell-based assay systems were developed and screening of natural product or natural resources have been performed.
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Report
(3 results)
Research Products
(6 results)
