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Involvement of TRPC channels in sympathetically-regulated bone metabolism

Research Project

Project/Area Number 21890276
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

KODAMA Daisuke  Aichi Gakuin University, 歯学部, 助教 (40549979)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,392,000 (Direct Cost: ¥1,840,000、Indirect Cost: ¥552,000)
Fiscal Year 2010: ¥1,066,000 (Direct Cost: ¥820,000、Indirect Cost: ¥246,000)
Fiscal Year 2009: ¥1,326,000 (Direct Cost: ¥1,020,000、Indirect Cost: ¥306,000)
Keywords交感神経 / 骨芽細胞 / イオンチャネル / 交感神経系 / Kチャネル / Gタンパク共役型受容体
Research Abstract

By using patch clamp methods, effects of noradrenaline on ion channels were investigated in human osteoblast, SaM-1. The results in this study indicated that noradrenaline inhibited K channels via α1B-adrenergic receptors. The effect was independent of protein kinase C and intracellular Ca^<2+> concentration. This suggested that G_q protein-coupled receptor was not involved in the effect. This study will aid our understanding of the mechanism behind the regulation of bone metabolism by the sympathetic nervous system.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Modulation of potassium channels via the α_<1B>-adrenergic receptor inhuman osteoblast.2010

    • Author(s)
      Daisuke Kodama, Akifumi Togari
    • Journal Title

      Neuroscience letters 485

      Pages: 102-106

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of potassium channels via the α_<1B>-adrenergic receptor in human osteoblast2010

    • Author(s)
      Daisuke, Kodama, Akifumi Togari
    • Journal Title

      Neuroscience Letters

      Volume: 485 Pages: 102-106

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Modulation of potassium channels via the α_<1B>-adrenergic receptor in human osteoblasts.2011

    • Author(s)
      兒玉大介,戸苅彰史
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Modulation of potassium channels via the α_<1B>-adrenergic receptor in human osteoblasts2011

    • Author(s)
      兒玉大介、戸苅彰史
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト骨芽細胞SaM-1におけるα_<1B>-アドレナリン受容体刺激のシグナル伝達経路について2010

    • Author(s)
      兒玉大介,戸苅彰史
    • Organizer
      第47回日本口腔組織培養学会学術大会
    • Place of Presentation
      高知
    • Year and Date
      2010-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト骨芽細胞SaM-1におけるα_<1B>-アドレナリン受容体刺激のシグナル伝達経路について2010

    • Author(s)
      兒玉大介、戸苅彰史
    • Organizer
      第47回日本口腔組織培養学会学術大会
    • Place of Presentation
      高知県教育会館高知城ホール
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト骨芽細胞におけるα_<1B>-アドレナリン受容体を介したKチャネルの抑制2010

    • Author(s)
      兒玉大介,戸苅彰史
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト骨芽細胞におけるα_<1B>-アドレナリン受容体を介したKチャネルの抑制2010

    • Author(s)
      兒玉大介、戸苅彰史
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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