| Project/Area Number |
21890303
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Hokkaido University |
|---|
Principal Investigator |
HIBI Terumasa Hokkaido University, 電子科学研究所, 助教 (50554292)
|
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,652,000 (Direct Cost: ¥2,040,000、Indirect Cost: ¥612,000)
Fiscal Year 2010: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2009: ¥1,391,000 (Direct Cost: ¥1,070,000、Indirect Cost: ¥321,000)
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| Keywords | 骨代謝 / 小胞輸送 / バイオイメージング / 多光子顕微鏡 / 蛍光蛋白質 |
|---|
| Research Abstract |
Bone is maintained by a balance between bone formation and resorption. The osteoclast is the cell that plays a major role in bone resorption in our body. In this study, to elucidate the molecular mechanism of bone resorption, vesicular trafficking in osteoclast was analyzed. By carrying out 4D-imaging, it becomes possible to analyze dynamics of acidic vesicles, probably involved in bone resorption, in living osteoclast not only horizontally but also vertically.
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