Clarify the role of mitochondria function on the development of fatty liver and hepatic carcinogenesis by targeting Apop-1

• Project/Area Number: 21H03369
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Mukogawa Women's University
• Principal Investigator: 福尾 惠介 武庫川女子大学, 食物栄養科学部, 教授 (40156758)
• Co-Investigator(Kenkyū-buntansha): 安田 修 鹿屋体育大学, スポーツ生命科学系, 教授 (00372615) ; 西川 浩樹 大阪医科薬科大学, 医学部, 教授 (30769609) ; 榎本 平之 兵庫医科大学, 医学部, 教授 (40449880) ; 大谷 直子 大阪公立大学, 大学院医学研究科, 教授 (50275195) ; 横路 三有紀 武庫川女子大学短期大学部, 食生活学科, 講師 (80757188)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2023: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2022: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2021: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: ミトコンドリア / 脂肪肝 / 肝発がん / 老化

Outline of Research at the Start

本研究は、我々が発見したミトコンドリア蛋白質Apop-1を標的とし、基礎研究では、Apop-1欠損マウスと野生型マウスを用いて、ほぼ100%高脂肪食誘導性肝がんを発症する系における肝星細胞の細胞老化やミトコンドリア機能異常、肝発がんの程度を比較検討する。臨床研究では、非アルコール性脂肪性肝疾患/非アルコール性脂肪性肝炎患者を対象として、Apop-1 SNP解析により、臨床所見や組織所見（脂肪化・炎症・線維化・肝星細胞の老化）、さらに累積発がん率とApop-1との関係を検討する。すなわち、Apop-1に焦点を当て、基礎と臨床の両面から、脂肪肝から肝がんへの発症機構を明らかにするものである。

Outline of Annual Research Achievements

（１）基礎研究
APOP1ノックアウトマウス（ApopKO）と野生型マウスの肝臓組織を使って、シングルセルRNA-seq解析を実施した。その結果、ApopKOの肝臓組織を構成する多くの細胞で自然免疫シグナルが活性化していることが分かった。このメカニズムとしては、ミトコンドリア機能のdysfunctionにより、ミトコンドリアDNAを介した自然免疫が活性化し、抗腫瘍免疫が活性化された可能性について、今後検証する。
マウス肝臓組織のRNA抽出し、次世代シーケンス解析したところ、Pyruvate dehydrogenase kinase isoform 4（PDK4）の発現がApopKO＋高脂肪食負荷でのみ発現低下が認められた。また、WTおよびApopKOマウス肝臓のpdk4遺伝子発現をqPCRで確認し、ApopKO＋高脂肪食群でpdk4遺伝子発現が有意に低下していることを認め、ApopKOによる発がん抑制メカニズムとして、PDK4の関与が示唆された。
（２）臨床研究
NAFLD/NASH例で肝生検を行った症例について、遺伝子同意とサンプル取得のある症例 (N=82) でApop-1の遺伝子多型の測定を行った。NAFLD/NASH ではApop-1のMinor alleleを有する例では脂肪化の程度や合併率が高い傾向にあった。また線維化マーカーは高値で血小板は低値であり、その傾向は男性症例で強く、Apo-1の遺伝子多型がNAFLD/NASHの発症や進展に関連する可能性が示唆された。
NASHの病態にはインスリン抵抗性が関わっているが、96名の肝がん患者を含む267名の肝疾患患者を対象として、サルコペニアと生命予後との関係を検討し、サルコペニアのスクリーニング指標であるSARC-Fが１以上であることと生命予後との間に関連が認められる可能性を示した。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Impact of the Coronavirus Disease 2019 Pandemic on Medical Practices in Awaji Island (2024)
  • Author(s): Omori Y, Oka N, Suzuki Y, Shima M, Nishikawa H, Tsuzuki K
  • Journal Title: JMA Journal Volume: 7 Issue: 1 Pages: 61-69
  • DOI: 10.31662/jmaj.2023-0107
  • ISSN: 2433-328X, 2433-3298
  • Year and Date: 2024-01-15
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of serum eicosapentaenoic acid/arachidonic acid ratio on overall survival in lung cancer patients treated with pembrolizumab: a pilot study (2024)
  • Author(s): Tanaka Ikue、Yano Yukihiro、Mori Masahide、Manabe Satoru、Fukuo Keisuke
  • Journal Title: Scientific Reports Volume: 14 Issue: 1 Pages: 1384-1384
  • DOI: 10.1038/s41598-024-51967-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Body Composition in Chronic Liver Disease (2024)
  • Author(s): Nishikawa Hiroki、Kim Soo Ki、Asai Akira
  • Journal Title: International Journal of Molecular Sciences Volume: 25 Issue: 2 Pages: 964-964
  • DOI: 10.3390/ijms25020964
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-Term Outcomes after Switching to Tenofovir Alafenamide in Patients with Chronic Hepatitis B (2024)
  • Author(s): Nishikawa Tomohiro、Matsui Masahiro、Onishi Saori、Ushiro Kosuke、Asai Akira、Kim Soo-Ki、Nishikawa Hiroki
  • Journal Title: International Journal of Molecular Sciences Volume: 25 Issue: 4 Pages: 2245-2245
  • DOI: 10.3390/ijms25042245
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of exclusive internal endoscopic drainage for complex biloma with transluminal and transpapillary stenting (2024)
  • Author(s): Sakamoto Jun、Ogura Takeshi、Ueno Saori、Okuda Atsushi、Nishioka Nobu、Hakoda Akitoshi、Uba Yuki、Tomita Mitsuki、Hattori Nobuhiro、Nakamura Junichi、Bessho Kimi、Nishikawa Hiroki
  • Journal Title: Endoscopy International Open Volume: 12 Issue: 02 Pages: E262-E268
  • DOI: 10.1055/a-2261-3137
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study (2024)
  • Author(s): Noriyuki Nakajima, Toshihisa Takeuchi, Junichi Iwamoto
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 74 Issue: 1 Pages: 82-89
  • DOI: 10.3164/jcbn.23-82
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endoscopic hemostasis using self-expandable metal stent combined with PuraStat? for patient with high risk of post-endoscopic sphincterotomy bleeding (with video) (2024)
  • Author(s): Ogura Takeshi、Uba Yuki、Yamamura Masahiro、Nishioka Nobu、Nishikawa Hiroki
  • Journal Title: Hepatobiliary & Pancreatic Diseases International Volume: 23 Issue: 1 Pages: 94-96
  • DOI: 10.1016/j.hbpd.2023.02.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between asymmetric dimethylarginine and sarcopenia in community-dwelling older women (2023)
  • Author(s): Yokoro Miyuki、Otaki Naoto、Yano Megumu、Imamura Tomomi、Tanino Norikazu、Fukuo Keisuke
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 5510-5510
  • DOI: 10.1038/s41598-023-32046-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations of alanine aminotransferase/aspartate aminotransferase with insulin resistance and β-cell function?in women (2023)
  • Author(s): Minato-Inokawa Satomi、Tsuboi-Kaji Ayaka、Honda Mari、Takeuchi Mika、Kitaoka Kaori、Kurata Miki、Wu Bin、Kazumi Tsutomu、Fukuo Keisuke
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 7853-7853
  • DOI: 10.1038/s41598-023-35001-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Low Dietary Variety Is Associated with Incident Frailty in Older Adults during the Coronavirus Disease 2019 Pandemic: A Prospective Cohort Study in Japan (2023)
  • Author(s): Miyuki Yokoro , Naoto Otaki , Megumu Yano , Tomomi Imamura , Norikazu Tanino and Keisuke Fukuo
  • Journal Title: nutrients Volume: 15 Issue: 5 Pages: 1145-1157
  • DOI: 10.3390/nu15051145
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between serum leptin concentrations and homeostasis model assessment-insulin resistance of 2.5 and higher in normal weight Japanese women (2023)
  • Author(s): Minato-Inokawa Satomi、Hayashida Yuuna、Honda Mari、Tsuboi-Kaji Ayaka、Takeuchi Mika、Kitaoka Kaori、Kurata Miki、Wu Bin、Kazumi Tsutomu、Fukuo Keisuke
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 8217-8217
  • DOI: 10.1038/s41598-023-35490-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Positive Correlation Between Changes in Serum Albumin Levels and Breakfast Non-Protein Calorie/Nitrogen Ratio in Geriatric Patients (2023)
  • Author(s): Fukuda Yasuko、Ochi Mikako、Kanazawa Ryouko、Nakajima Hiromu、Fukuo Keisuke、Nakai Masanobu
  • Journal Title: Journal of Clinical Medicine Research Volume: 15 Issue: 2 Pages: 109-115
  • DOI: 10.14740/jocmr4848
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between social network and dietary variety among community-dwelling older adults (2023)
  • Author(s): Yokoro Miyuki、Otaki Naoto、Imamura Tomomi、Tanino Norikazu、Fukuo Keisuke
  • Journal Title: Public Health Nutrition Volume: 26 Issue: 11 Pages: 2441-2449
  • DOI: 10.1017/s1368980023001325
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nutritional Interpretation of Hospital Diets for Elderly Patients With Chronic Diseases and Analysis of Factors Influencing Actual Intakes (2023)
  • Author(s): Fukuda Yasuko、Ochi Mikako、Kanazawa Ryouko、Nakajima Hiromu、Fukuo Keisuke、Nakai Masanobu
  • Journal Title: Journal of Clinical Medicine Research Volume: 15 Issue: 6 Pages: 321-327
  • DOI: 10.14740/jocmr4961
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between Dietary Variety and Frailty in Community-Dwelling Older People Who Live Alone: Gender Differences. (2023)
  • Author(s): Yokoro Miyuki, Otaki Naoto, Yano Megumu, Tani Mariko, Tanino Norikazu, Fukuo Keisuke
  • Journal Title: J Frailty Aging Volume: 12 Pages: 30-36
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of PNPLA3 SNP With the Development of HBV-related Hepatocellular Carcinoma (2023)
  • Author(s): ENOMOTO HIRAYUKI、AIZAWA NOBUHIRO、IKEDA NAOTO、TAKASHIMA TOMOYUKI、YURI YUKIHISA、OKAMOTO MAMIKO、YOSHIOKA RYOTA、KAWATA SHOKI、YOSHIHARA KOHEI、OTA SHOGO、NAKANO RYOTA、SHIOMI HIDEYUKI、NISHIMURA TAKASHI、IIJIMA HIROKO
  • Journal Title: In Vivo Volume: 37 Issue: 2 Pages: 763-770
  • DOI: 10.21873/invivo.13139
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Determination of the Possible Target Genes of Hepatoma-derived Growth Factor in Hepatoma Cells (2023)
  • Author(s): ENOMOTO HIRAYUKI、NISHIMURA TAKASHI、FUKUNUSHI SHINYA、SHIOMI HIDEYUKI、IIJIMA HIROKO
  • Journal Title: In Vivo Volume: 37 Issue: 5 Pages: 1975-1979
  • DOI: 10.21873/invivo.13294
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Low Geriatric Nutritional Risk Index Is Associated with Low Muscle Volume and a Poor Prognosis among Cirrhotic Patients (2023)
  • Author(s): Enomoto Hirayuki、Yuri Yukihisa、Nishimura Takashi、Ikeda Naoto、Takashima Tomoyuki、Aizawa Nobuhiro、Okamoto Mamiko、Yoshihara Kohei、Yoshioka Ryota、Kawata Shoki、Kawase Yuta、Nakano Ryota、Shiomi Hideyuki、Fukunishi Shinya、Shinzaki Shinichiro、Iijima Hiroko
  • Journal Title: Medicina Volume: 59 Issue: 12 Pages: 2099-2099
  • DOI: 10.3390/medicina59122099
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolic dysfunction‐associated steatotic liver disease criteria may underestimate the number of lean female nonalcoholic fatty liver disease patients with significant liver fibrosis (2023)
  • Author(s): Kobayashi Natsuko、Tada Toshifumi、Nishimura Takashi、Matono Tomomitsu、Yuri Yukihisa、Takashima Tomoyuki、Aizawa Nobuhiro、Ikeda Naoto、Fukunishi Shinya、Hashimoto Mariko、Ohyanagi Mitsumasa、Enomoto Hirayuki、Iijima Hiroko
  • Journal Title: Hepatology Research Volume: 54 Issue: 5 Pages: 429-438
  • DOI: 10.1111/hepr.13994
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Body Composition Analysis in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease (2023)
  • Author(s): Onishi Saori、Fukuda Akira、Matsui Masahiro、Ushiro Kosuke、Nishikawa Tomohiro、Asai Akira、Kim Soo Ki、Nishikawa Hiroki
  • Journal Title: Nutrients Volume: 15 Issue: 18 Pages: 3878-3878
  • DOI: 10.3390/nu15183878
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Liver Carcinogenesis Suppression in Chronic Hepatitis B in the Nucleoside Analogues Era (2023)
  • Author(s): NISHIKAWA HIROKI、KIM SOO KI、ASAI AKIRA
  • Journal Title: In Vivo Volume: 38 Issue: 1 Pages: 40-47
  • DOI: 10.21873/invivo.13408
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Frontiers in Endoscopic Treatment for Gastroesophageal Reflux Disease (2023)
  • Author(s): Ota Kazuhiro、Takeuchi Toshihisa、Higuchi Kazuhide、Sasaki Shun、Mori Yosuke、Tanaka Hironori、Hakoda Akitoshi、Sugawara Noriaki、Iwatsubo Taro、Nishikawa Hiroki
  • Journal Title: Digestion Volume: 105 Issue: 1 Pages: 5-10
  • DOI: 10.1159/000533200
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transluminal antegrade drill dilation technique for hepaticojejunostomy stricture with cholangioscopic evaluation (with video) (2023)
  • Author(s): Kanadani Takafumi、Ogura Takeshi、Ueno Saori、Okuda Atsushi、Nishioka Nobu、Nakamura Junichi、Yamada Masanori、Uba Yuki、Tomita Mitsuki、Hattori Nobuhiro、Sakamoto Jun、Nishikawa Hiroki
  • Journal Title: Endoscopy International Open Volume: 12 Issue: 02 Pages: E181-E187
  • DOI: 10.1055/a-2218-1538
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic Nutritional Index Correlates with Liver Function and Prognosis in Chronic Liver Disease Patients (2023)
  • Author(s): Matsui Masahiro、Asai Akira、Ushiro Kosuke、Onishi Saori、Nishikawa Tomohiro、Ohama Hideko、Tsuchimoto Yusuke、Kim Soo Ki、Nishikawa Hiroki
  • Journal Title: Diagnostics Volume: 14 Issue: 1 Pages: 49-49
  • DOI: 10.3390/diagnostics14010049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between the Suita Score and Body Composition in Japanese Adults: A Large Cross-Sectional Study (2023)
  • Author(s): Onishi Saori、Fukuda Akira、Matsui Masahiro、Ushiro Kosuke、Nishikawa Tomohiro、Asai Akira、Kim Soo Ki、Nishikawa Hiroki
  • Journal Title: Nutrients Volume: 15 Issue: 22 Pages: 4816-4816
  • DOI: 10.3390/nu15224816
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese Adults (2023)
  • Author(s): Matsui Masahiro、Fukuda Akira、Onishi Saori、Ushiro Kosuke、Nishikawa Tomohiro、Asai Akira、Kim Soo Ki、Nishikawa Hiroki
  • Journal Title: Nutrients Volume: 15 Issue: 22 Pages: 4724-4724
  • DOI: 10.3390/nu15224724
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Accurate SARC-F Score in Patients with Liver Disease (2023)
  • Author(s): Matsui Masahiro、Asai Akira、Ushiro Kosuke、Onishi Saori、Nishikawa Tomohiro、Yokohama Keisuke、Ohama Hideko、Tsuchimoto Yusuke、Kim Soo Ki、Nishikawa Hiroki
  • Journal Title: Diagnostics Volume: 13 Issue: 11 Pages: 1959-1959
  • DOI: 10.3390/diagnostics13111959
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of Switching to Adalimumab for Maintenance of Remission Following Induction Therapy with Tacrolimus in Patients with Ulcerative Colitis (2023)
  • Author(s): Numa Keijiro、Kakimoto Kazuki、Tanaka Yasuyoshi、Mizuta Noboru、Kinoshita Naohiko、Nakazawa Kei、Koshiba Ryoji、Hirata Yuki、Ota Kazuhiro、Miyazaki Takako、Nakamura Shiro、Higuchi Kazuhide、Nishikawa Hiroki
  • Journal Title: Journal of Clinical Medicine Volume: 12 Issue: 20 Pages: 6699-6699
  • DOI: 10.3390/jcm12206699
• [Journal Article] Oral Microbial Profile Analysis in Patients with Oral and Pharyngeal Cancer Reveals That Tumoral Fusobacterium nucleatum Promotes Oral Cancer Progression by Activating YAP (2023)
  • Author(s): Yamamoto Yuki、Kamiya Tomonori、Yano Megumu、Huyen Vu Thuong、Oishi Masahiro、Nishio Miki、Suzuki Akira、Sunami Kishiko、Ohtani Naoko
  • Journal Title: Microorganisms Volume: 11 Issue: 12 Pages: 2957-2957
  • DOI: 10.3390/microorganisms11122957
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visualization of hydrocarbon chain length and degree of saturation of fatty acids in mouse livers by combining near-infrared hyperspectral imaging and machine learning (2023)
  • Author(s): Mori Akino、Umezawa Masakazu、Okubo Kyohei、Kamiya Tomonori、Kamimura Masao、Ohtani Naoko、Soga Kohei
  • Journal Title: Scientific Reports Volume: 13 Issue: 1
  • DOI: 10.1038/s41598-023-47565-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance (2023)
  • Author(s): Takasugi Masaki、Ohtani Naoko、Takemura Kazuaki、Emmrich Stephan、Zakusilo Frances T.、Yoshida Yuya、Kutsukake Nobuyuki、Mariani John N.、Windrem Martha S.、Chandler-Militello Devin、Goldman Steven A.、Satoh Junko、Ito Shinji、Seluanov Andrei、Gorbunova Vera
  • Journal Title: Cell Reports Volume: 42 Issue: 9 Pages: 113130-113130
  • DOI: 10.1016/j.celrep.2023.113130
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gene expressions associated with longer lifespan and aging exhibit similarity in mammals (2023)
  • Author(s): Takasugi Masaki、Yoshida Yuya、Nonaka Yoshiki、Ohtani Naoko
  • Journal Title: Nucleic Acids Research Volume: 51 Issue: 14 Pages: 7205-7219
  • DOI: 10.1093/nar/gkad544
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bacterial induction of B cell senescence promotes age-related changes in the gut microbiota (2023)
  • Author(s): Kawamoto Shimpei、Uemura Ken、Hori Nozomi、Takayasu Lena、Konishi Yusuke、Katoh Kazutaka、Matsumoto Tomonori、Suzuki Masae、Sakai Yusuke、Matsudaira Tatsuyuki、Adachi Takahiro、Ohtani Naoko、Standley Daron M.、Suda Wataru、Fukuda Shinji、Hara Eiji
  • Journal Title: Nature Cell Biology Volume: 25 Issue: 6 Pages: 865-876
  • DOI: 10.1038/s41556-023-01145-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Recent updates on the role of the gut-liver axis in the pathogenesis of NAFLD/NASH, HCC, and beyond (2023)
  • Author(s): Ohtani Naoko、Kamiya Tomonori、Kawada Norifumi
  • Journal Title: Hepatology Communications Volume: 7 Issue: 9
  • DOI: 10.1097/hc9.0000000000000241
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes (2023)
  • Author(s): Yoshinori Okina, Misako Sato-Matsubara, Yasutoshi Kido, Hayato Urushima, Atsuko Daikoku, Chiho Kadono, Yu Nakagama, Yuko Nitahara, Truong Huu Hoang, Le Thi Thanh Thuy, Tsutomu Matsubara, Naoko Ohtani, Kazuo Ikeda, Katsutoshi Yoshizato, Norifumi Kawada.
  • Journal Title: Antioxid Redox Signal. Volume: 38 Pages: 463-479
  • DOI: 10.1089/ars.2021.0279
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between Dietary Variety and Frailty in Community-Dwelling Older People Who Live Alone: Gender Differences (2023)
  • Author(s): Yokoro M, Otaki N, Yano M, Tani M, Tanino N, Fukuo K.
  • Journal Title: J Frailty Aging Volume: 12 Pages: 30-36
  • Peer Reviewed
• [Journal Article] 漢字・食育融合教材の開発ー持続可能な学習機会の創出を目指して― (2023)
  • Author(s): 設樂馨, 𠮷井美奈子, 横路三有紀
  • Journal Title: 武庫川女子大学 学校教育センター紀要 Volume: 8 Pages: 43-56
  • Peer Reviewed
• [Journal Article] Characterization of Transcriptomic and Proteomic Changes in the Skin after Chronic Fluocinolone Acetonide Treatment (2022)
  • Author(s): Choi Y, Takasugi M, Takemura K, Yoshida Y, Kamiya T, Adachi J, Tsuruta D, Ohtani N
  • Journal Title: Biomolecules Volume: 12 Issue: 12 Pages: 1822-1822
  • DOI: 10.3390/biom12121822
  • Peer Reviewed / Open Access
• [Journal Article] Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus?Sustained Virological Response Patients (2022)
  • Author(s): Dong Minh Phuong、Thuy Le Thi Thanh、Hoang Dinh Viet、Hai Hoang、Hoang Truong Huu、Sato-Matsubara Misako、Hieu Vu Ngoc、Daikoku Atsuko、Hanh Ngo Vinh、Urushima Hayato、Dat Ninh Quoc、Uchida-Kobayashi Sawako、Enomoto Masaru、Ohtani Naoko、Tamori Akihiro、Kawada Norifumi
  • Journal Title: The American Journal of Pathology Volume: 192 Issue: 10 Pages: 1379-1396
  • DOI: 10.1016/j.ajpath.2022.07.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms. (2022)
  • Author(s): Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N.
  • Journal Title: Sci Adv. Volume: 8(39) Issue: 39 Pages: 5525-5525
  • DOI: 10.1126/sciadv.abo5525
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct responsiveness to rifaximin in patients with hepatic encephalopathy depends on functional gut microbial species (2022)
  • Author(s): Yukawa-Muto Y, Kamiya T, Fujii H, Mori H, Toyoda A, Sato I, Konishi Y, Hirayama A, Hara E, Fukuda S, Kawada N, Ohtani N
  • Journal Title: Hepatol Commun Volume: 6 Issue: 8 Pages: 2090-2104
  • DOI: 10.1002/hep4.1954
  • Peer Reviewed / Open Access
• [Journal Article] Development and evaluation of a colorectal cancer screening method using machine learning-based gut microbiota analysis (2022)
  • Author(s): Konishi Y, Okumura S, Matsumoto T, Itatani Y, Nishiyama T, Okazaki Y, Shibutani M, Ohtani N, Nagahara H, Obama K, Ohira M, Sakai Y, Nagayama S, Hara E
  • Journal Title: Cancer Med Volume: 11 Issue: 16 Pages: 3194-3206
  • DOI: 10.1002/cam4.4671
  • Peer Reviewed / Open Access
• [Journal Article] Non-heat-stressed Method to Isolate Hepatic Stellate Cells From Highly Steatotic Tumor-bearing Liver Using CD49a. (2022)
  • Author(s): Yi Cheng, Ryota Yamagishi, Yoshiki Nonaka, Misako Sato-Matsubara, Norifumi Kawada, Naoko Ohtani
  • Journal Title: Cellular and molecular gastroenterology and hepatology Volume: 14 Issue: 4 Pages: 964-966
  • DOI: 10.1016/j.jcmgh.2022.07.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gasdermin D?mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma (2022)
  • Author(s): Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N
  • Journal Title: Science Immunology Volume: 7 Issue: 72 Pages: 1-15
  • DOI: 10.1126/sciimmunol.abl7209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species (2022)
  • Author(s): Hoang Dinh Viet、Thuy Le Thi Thanh、Hai Hoang、Hieu Vu Ngoc、Kimura Kenjiro、Oikawa Daisuke、Ikura Yoshihiro、Dat Ninh Quoc、Hoang Truong Huu、Sato-Matsubara Misako、Dong Minh Phuong、Hanh Ngo Vinh、Uchida-Kobayashi Sawako、Tokunaga Fuminori、Kubo Shoji、Ohtani Naoko、Yoshizato Katsutoshi、Kawada Norifumi
  • Journal Title: Oncogenesis Volume: 11 Issue: 1 Pages: 1-13
  • DOI: 10.1038/s41389-022-00389-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The role of cellular senescence and SASP in tumour microenvironment (2022)
  • Author(s): Takasugi M, Yoshida Y, Hara E, Ohtani N
  • Journal Title: FEBS J Volume: 290 Issue: 5 Pages: 1348-1361
  • DOI: 10.1111/febs.16381
  • Peer Reviewed
• [Journal Article] Cellular senescence and the tumour microenvironment (2022)
  • Author(s): Takasugi M, Yoshida Y, Ohtani N
  • Journal Title: Mol Oncol Volume: 16 Issue: 18 Pages: 3333-3351
  • DOI: 10.1002/1878-0261.13268
  • Peer Reviewed
• [Journal Article] The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors. (2022)
  • Author(s): Kamiya T, Ohtani N
  • Journal Title: Int Immunol Volume: 34 Issue: 9 Pages: 467-474
  • DOI: 10.1093/intimm/dxac020
  • Peer Reviewed
• [Journal Article] The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? (2022)
  • Author(s): Ohtani N
  • Journal Title: Inflamm Regen Volume: 42 Issue: 1 Pages: 11-11
  • DOI: 10.1186/s41232-022-00197-8
  • Peer Reviewed
• [Journal Article] Risk stratification of decompensation using liver stiffness and platelet counts in compensated advanced chronic liver disease (CHESS2102) (2022)
  • Author(s): Liu Y., Liu C., Li J., Kim T.H., Enomoto H., Qi X
  • Journal Title: J Hepatol Volume: 76 Pages: 248-250
  • Peer Reviewed
• [Journal Article] Modification of the ALBI-PLT Score for the Prediction of High-risk Varices. (2022)
  • Author(s): Inoue-Yuri M., Enomoto H., Wakabayashi I., Yuri Y., Aizawa N., Ikeda N., Takashima T., Fujiwara A., Yoshioka R., Kawata S., Yoshihara K., Ota S., Nakano R., Shiomi H., Nishimura T., Nishiguchi S., Iijima H.
  • Journal Title: In Vivo Volume: 36 Pages: 1360-1366
  • Peer Reviewed
• [Journal Article] Possible Alterations in Appetite-related Molecules After the Elimination of Hepatitis C Virus (2022)
  • Author(s): Shimono Y., Enomoto H., Aizawa N., Takashima T., Ikeda N., Yuri Y., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Iijima H
  • Journal Title: In Vivo Volume: 36 Pages: 1491-1496
  • Peer Reviewed
• [Journal Article] ABC: a novel algorithm to stratify decompensation risk in patients with compensated advanced chronic liver disease (CHESS2108): an international, multicenter cohort study (2022)
  • Author(s): Liu C., Li J., Wong Y.J., Xie Q., Hirooka M., Enomoto H., Kim T.H., Hanafy A.S., He R., Koizumi Y., Hiasa Y., Nishimura T., Iijima H., Jung Y.K., Yim H.J., Ma J., Zeng Q.L., Sarin S.K., Qi X.
  • Journal Title: Hepatol Int Volume: 6 Pages: 1105-1115
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Novel SAVE Score to Stratify Decompensation Risk in Compensated Advanced Chronic Liver Disease (CHESS2102): An International Multicenter Cohort Study. (2022)
  • Author(s): Liu C., Cao Z., Yan H., Wong Y.J., Xie Q., Hirooka M., Enomoto H., Kim T.H., Hanafy A.S., Liu Y., Huang Y., Li X., Kang N., Koizumi Y., Hiasa Y., Nishimura T., Iijima H., Jung Y.K., Yim H.J., Guo Y., Zhang L., Ma J, Kumar M, Jindal A, Teh KB, Sarin SK, Qi X.
  • Journal Title: Am J Gastroenterol Volume: 117 Pages: 1605-1613
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] No increased risk of hepatocellular carcinoma after eradication of hepatitis C virus by direct-acting antivirals, compared with interferon-based therapy (2022)
  • Author(s): Korenaga M., Murata K., Izumi N, Tamaki N., Yokosuka O., Takehara T., Sakamoto N., Suda G., Nishiguchi S., Enomoto H., Ikeda F.,et al
  • Journal Title: Glob Health Med Volume: 4 Pages: 216-224
  • Peer Reviewed
• [Journal Article] Diagnosis of hepatic steatosis based on ultrasound attenuation imaging is not influenced by liver fibrosis. (2022)
  • Author(s): Yuri M., Nishimura T., Tada T., Yoshida M., Fujiwara A., Kawata S., Yoshihara K., Yoshioka R., Ota S., Nakano R., Yuri Y., Takashima T., Aizawa N., Ikeda N., Shiomi H., Ide Y.H., Enomoto H., Yasuhiro F., Yano H., Iijima H
  • Journal Title: Hepatol Res Volume: 52 Pages: 1009-1019
  • Peer Reviewed
• [Journal Article] Liver cirrhosis in Japan: Future global trends in the era of progressive antiviral therapy. (2022)
  • Author(s): Enomoto H., Takashima T., Nishimura T., Aizawa N., Ikeda N., Yuri Y., Okamoto, M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Iijima H
  • Journal Title: Port Hypertens Cirrhos Volume: 1 Pages: 178-183
  • Peer Reviewed
• [Journal Article] Clinical Characteristics of ICI-Related Pancreatitis and Cholangitis Including Radiographic and Endoscopic Findings (2022)
  • Author(s): Nakano R., Shiomi H., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Yuri Y., Takashima T., Aizawa N., Ikeda N., Nishimura T., Enomoto H., Iijima H
  • Journal Title: Healthcare Volume: 10 Pages: 76-76
  • Peer Reviewed
• [Journal Article] Acute Liver Failure and Acute-on-Chronic Liver Failure in COVID-19 Era (2022)
  • Author(s): Kanda T., Sasaki-Tanaka R., Ishii T., Abe H., Ogawa M., Enomoto H
  • Journal Title: J Clin Med Volume: 11 Pages: 4249-4249
  • Peer Reviewed
• [Journal Article] Branched chain amino acid-to-tyrosine ratio: not only an indicator of the amino acid imbalance. (2022)
  • Author(s): Enomoto H., Nishimura T., Aizawa N., Takashima T., Ikeda N., Yuri Y., Fujiwara, A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Iijima H
  • Journal Title: Digestive Medicine Research. Dig Med Res Volume: 6 Pages: 1-1
  • Peer Reviewed
• [Journal Article] Multiple Inflammatory Pseudotumors of the Liver Demonstrating Spontaneous Regression: A Case Report. (2022)
  • Author(s): Ishii-Kitano N., Enomoto H., Nishimura T., Aizawa N., Shibata Y., Higashiura A., Takashima T., Ikeda N., Yuri Y., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Hirota S., Kumabe T., Nakashima O., Iijima H.
  • Journal Title: Life Volume: 12 Pages: 124-124
  • Peer Reviewed
• [Journal Article] Metastasis of Hepatocellular Carcinoma in the Pouch of Douglas Successfully Treated by Radiation Therapy: A Case Report (2022)
  • Author(s): Enomoto H., Fujiwara M., Kono H., Kako Y., Takahagi M., Taniguchi J., Ishikawa E., Ikeda N., Takashima T., Yuri Y., Aizawa N., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Hirota S., Yamakado K., Iijima H.
  • Journal Title: Life Volume: 13 Pages: 225-225
  • Peer Reviewed
• [Journal Article] Recanalization using a novel drill-shaped dilator for a severe pancreatic duct stricture and impacted pancreatic duct stone (2022)
  • Author(s): Shiomi H., Nakano R., Ota S., Nishimura T., Enomoto H., Iijima H
  • Journal Title: Endoscopy Volume: 55
  • Peer Reviewed
• [Journal Article] The Significance of Zinc in Patients with Chronic Liver Disease (2022)
  • Author(s): Nishikawa H, Asai A, Fukunishi S
  • Journal Title: Nutrients Volume: 14 Pages: 4855-4855
  • Peer Reviewed
• [Journal Article] Grip Strength in Patients with Gastrointestinal Diseases. (2022)
  • Author(s): Asaishi K, Matsui M, Nishikawa H, Goto M, Asai A, Ushiro K, Ogura T, Takeuchi T, Nakamura S, Kakimoto K, Miyazaki T, Fukunishi S, Ohama H, Yokohama K, Yasuoka H, Higuchi K
  • Journal Title: J Clin Med Volume: 11 Pages: 2079-2079
  • Peer Reviewed
• [Journal Article] Risk Factors for Nephrotoxicity due to Tacrolimus Therapy for Ulcerative Colitis (2022)
  • Author(s): Nakata S, Kakimoto K, Numa K, Kinoshita N, Kawasaki Y, Tatsumi Y, Tawa H, Koshiba R, Hirata Y, Ota K, Sakiyama N, Kojima Y, Nishikawa H, Inoue T, Takeuchi T, Fukunishi S, Miyazaki T, Nakamura S, Higuchi K
  • Journal Title: Digestion Volume: 103 Pages: 339-346
  • Peer Reviewed
• [Journal Article] The Relevance in the Neutrophil to Lymphocyte Ratio and the SARC-F Score in Gastrointestinal Diseases (2022)
  • Author(s): Yamasaki E, Nishikawa H, Goto M, Matsui M, Asai A, Ushiro K, Ogura T, Takeuchi T, Nakamura S, Kakimoto K, Miyazaki T, Fukunishi S, Ohama H, Yokohama K, Yasuoka H, Higuchi K
  • Journal Title: J Clin Med Volume: 11 Pages: 2012-2012
  • Peer Reviewed
• [Journal Article] CD34+CD10+CD19- Cells in Patients with Unhealthy Alcohol Use Stimulate the M2b Monocyte Polarization (2022)
  • Author(s): Asai A, Tsuchimoto Y, Ohama H, Nishikawa H, Chopra A, Higuchi K.
  • Journal Title: Cells Volume: 11 Pages: 2703-2703
  • Peer Reviewed
• [Journal Article] The Relationship between the SARC-F Score and the Controlling Nutritional Status Score in Gastrointestinal Diseases (2022)
  • Author(s): Ikegami T, Nishikawa H, Goto M, Matsui M, Asai A, Ushiro K, Ogura T, Takeuchi T, Nakamura S, Kakimoto K, Miyazaki T, Fukunishi S, Ohama H, Yokohama K, Yasuoka H, Higuchi K.
  • Journal Title: J Clin Med Volume: 11 Pages: 582-582
  • Peer Reviewed
• [Journal Article] A Prospective Study Regarding the Efficacy and Safety of the BNT162b2 Vaccine in Patients With Solid Malignancies Undergoing Systemic Chemotherapy. (2022)
  • Author(s): Yamasaki E, Shimamoto F, Nishikawa H, Goto M, Iwamoto M, Kimura K, Ukimura A, Oosaka N, Taniguchi K, Ono F, Terazawa T, Yamaguchi T, Asaishi K, Ikegami T, Uchiyama K, Nakamura S, Higuchi K
  • Journal Title: In Vivo Volume: 36 Pages: 2780-2789
  • Peer Reviewed
• [Journal Article] Clinical Importance of Body Composition in Improving Bone Mineral Density of Femoral Neck After Denosumab Therapy in Patients With Rheumatoid Arthritis or Collagen Diseases (2022)
  • Author(s): Nakano M, Miyake A, Egashira R, Takeuchi M, Moriguchi M, Tonari S, Saito H, Nishikawa H, Matsui K, Hagihara K
  • Journal Title: In Vivo Volume: 36 Pages: 1468-1476
  • Peer Reviewed
• [Journal Article] Effect of an Electronic Alert System on Hepatitis B Virus Reactivation in Patients Receiving Immunosuppressive Drug Therapy (2022)
  • Author(s): Asai A, Hirai S, Yokohama K, Nishikawa T, Nishikawa H, Higuchi K
  • Journal Title: J Clin Med Volume: 11 Pages: 2446-2446
  • Peer Reviewed
• [Journal Article] Comparison of Endoscopic Hemostasis for Endoscopic Sphincterotomy Bleeding between a Novel Self-Assembling Peptide and Conventional Technique (2022)
  • Author(s): Uba Y, Ogura T, Ueno S, Okuda A, Nishioka N, Miyano A, Yamamoto Y, Bessho K, Tomita M, Nakamura J, Hakoda A, Nishikawa H
  • Journal Title: J Clin Med Volume: 12 Pages: 79-79
  • Peer Reviewed
• [Journal Article] Therapeutic Drug Monitoring of Golimumab for the Prediction of Long-Term Clinical Remission in Patients with Ulcerative Colitis (2022)
  • Author(s): Tawa H, Kakimoto K, Numa K, Kinoshita N, Kawasaki Y, Tatsumi Y, Koshiba R, Nakata S, Hirata Y, Ota K, Sakiyama N, Kojima Y, Koubayashi E, Nishikawa H, Takeuchi T, Inoue T, Fukunishi S, Miyazaki T, Nakamura S, Higuchi K
  • Journal Title: Digestion Volume: 103 Pages: 329-338
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Ectopic Fat Deposition within Psoas Muscle in Stage IV Gastric Cancer Patients Undergoing Systemic Chemotherapy (2022)
  • Author(s): Ikegami T, Nishikawa H, Goto M, Shimamoto F, Terazawa T, Yamaguchi T, Yamasaki E, Asaishi K, Nakamura S, Higuchi K
  • Journal Title: J Cancer Volume: 13 Pages: 3477-3484
  • Peer Reviewed
• [Journal Article] Can Lemborexant for Insomnia Prevent Delirium in High-Risk Patients with Pancreato-Biliary Disease after Endoscopic Procedures under Deep Sedation? (2022)
  • Author(s): Ogura T, Ueno S, Okuda A, Nishioka N, Miyano A, Yamamoto Y, Bessho K, Tomita M, Hattori N, Nakamura J, Nishikawa H
  • Journal Title: J Clin Med Volume: 12 Pages: 297-297
  • Peer Reviewed
• [Journal Article] Birth weight was associated positively with gluteofemoral fat mass and inversely with 2-h postglucose insulin concentrations, a marker of insulin resistance, in young normal-weight Japanese women (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Megumu Yano, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Diabetol Int Volume: 13 Issue: 2 Pages: 375-380
  • DOI: 10.1007/s13340-021-00543-0
  • Peer Reviewed / Open Access
• [Journal Article] Positive Correlation Between Changes in Serum Albumin Levels and Breakfast Non-Protein Calorie/Nitrogen Ratio in Geriatric Patients (2022)
  • Author(s): Yasuko Fukuda, Mikako Ochi, Ryouko Kanazawa, Hiromu Nakajima, Keisuke Fukuo, Masanobu Nakai
  • Journal Title: J Clin Med Res Volume: 15 Pages: 109-115
  • Peer Reviewed / Open Access
• [Journal Article] Influence of the nutritional status on facial morphology in young Japanese women (2022)
  • Author(s): Chihiro Tanikawa, Miki Kurata, Noriko Tanizaki, Mika Takeuchi, Edlira Zere, Keisuke Fukuo, Kenji Takada
  • Journal Title: Sci Rep Volume: 12 Issue: 1 Pages: 18557-18557
  • DOI: 10.1038/s41598-022-21919-5
  • Peer Reviewed / Open Access
• [Journal Article] Reduced gluteofemoral (subcutaneous) fat mass in young Japanese women with family history of type 2 diabetes: an exploratory analysis (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Sci Rep Volume: 12 Issue: 1 Pages: 12579-12579
  • DOI: 10.1038/s41598-022-16890-0
  • Peer Reviewed / Open Access
• [Journal Article] Higher fasting glucose, triglycerides, resting pulse rate and high-sensitivity C reactive protein in adipose insulin-resistant but normal weight young Japanese women (2022)
  • Author(s): Satomi Minato-Inokawa, Mari Honda, Ayaka Tsuboi-Kaji, Mika Takeuchi, Kaori Kitaoka, Akiko Takenouchi, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: BMJ Open Diabetes Res Care Volume: 10 Issue: 6 Pages: e003013-e003013
  • DOI: 10.1136/bmjdrc-2022-003013
  • Peer Reviewed / Open Access
• [Journal Article] Weight trajectories since birth, current body composition and metabolic traits in young, normal-weight Japanese women with high percentage body fat (2022)
  • Author(s): Satomi Minato-Inokawa, Asami Hashiguchi, Mari Honda, Ayaka Tsuboi-Kaji, Mika Takeuchi, Kaori Kitaoka, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: BMJ Open Diabetes Res Care Volume: 10 Issue: 6 Pages: e003045-e003045
  • DOI: 10.1136/bmjdrc-2022-003045
  • Peer Reviewed / Open Access
• [Journal Article] Associations of Infant Feeding with Body Composition and Cardiometabolic Health in Young Female University Students (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Tomofumi Takayoshi, Yushi Hirota, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: J Womens Health Volume: 31 Issue: 9 Pages: 1358-1363
  • DOI: 10.1089/jwh.2021.0464
  • Peer Reviewed / Open Access
• [Journal Article] Serum Orosomucoid Is Associated with Serum Adiponectin, Adipose Tissue Insulin Resistance Index, and a Family History of Type 2 Diabetes in Young Normal Weight Japanese Women (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Mika Takeuchi, Miki Kurata, Tomofumi Takayoshi, Yushi Hirota, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: J Diabetes Res Volume: 2022 Pages: 7153238-7153238
  • DOI: 10.1155/2022/7153238
  • Peer Reviewed / Open Access
• [Journal Article] Weight Trajectory Since Birth, Current Body Composition, Dietary Intake, and Glucose Tolerance in Young Underweight Japanese Women (2022)
  • Author(s): Mika Takeuchi, Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Womens Health Rep Volume: 3 Issue: 1 Pages: 215-221
  • DOI: 10.1089/whr.2021.0127
  • Peer Reviewed
• [Journal Article] Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women (2022)
  • Author(s): Mari Honda, Ayaka Tsuboi, Satomi Minato-Inokawa, Kaori Kitaoka, Mika Takeuchi, Megumu Yano, Miki Kurata, Bin Wu, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Diabetol Int Volume: 13 Issue: 1 Pages: 220-225
  • DOI: 10.1007/s13340-021-00525-2
  • NAID: 40022802969
  • Peer Reviewed / Open Access
• [Journal Article] Social contact impacts physical activity and sedentary behavior among older adults in Japan due to COVID-19 (2022)
  • Author(s): Otaki Naoto、Yokoro Miyuki、Yano Megumu、Imamura Tomomi、Akita Michiko、Tanino Norikazu、Fukuo Keisuke
  • Journal Title: BMC Geriatrics Volume: 22 Issue: 1 Pages: 491-491
  • DOI: 10.1186/s12877-022-03188-z
  • Peer Reviewed / Open Access
• [Journal Article] 薬剤性小腸粘膜障害の診断におけるバルーン内視鏡とカプセル内視鏡の役割 (2022)
  • Author(s): 菅原 徳瑛(大阪医科薬科大学 第二内科), 太田 和寛, 森 洋介, 田中 宏典, 箱田 明俊, 岩坪 太郎, 平田 有基, 能田 貞治, 柿本 一城, 竹内 利寿, 樋口 和秀, 西川 浩樹
  • Journal Title: 消化器・肝臓内科 Volume: 12 Pages: 610-616
  • Peer Reviewed
• [Journal Article] クローン病に伴う短腸症候群への対応・治療法はどのようなものがあるのか (2022)
  • Author(s): 中村 志郎(大阪医科薬科大学 第二内科), 宮嵜 孝子, 柿本 一城, 平田 有基, 碕山 直邦, 小柴 良司, 峠 英樹, 中沢 啓, 川崎 裕香, 木下 直彦, 沼 圭次朗, 清水 光, 西田 光志, 西川 浩樹
  • Journal Title: 消化器・肝臓内科 Volume: 12 Pages: 442-450
  • Peer Reviewed
• [Journal Article] 非中毒性巨大結腸症を呈した大腸型Crohn病の1例 (2022)
  • Author(s): 佐野村 誠(北摂総合病院 消化器内科), 坂口 奈々子, 疋田 千晶, 辻 沙也佳, 内海 麻衣, 冨永 真央, 西川 知宏, 碕山 直邦, 西谷 仁, 柿本 一城, 中村 志郎, 西川 浩樹
  • Journal Title: 胃と腸 Volume: 57 Pages: 1490-1493
  • Peer Reviewed
• [Journal Article] 【潰瘍性大腸炎内科診療の新時代】基本治療薬と投与上の注意点 (2022)
  • Author(s): 中村 志郎, 宮嵜 孝子, 柿本 一城, 平田 有基, 碕山 直邦, 小柴 良司, 峠 英樹, 中沢 啓, 川崎 裕香, 木下 直彦, 沼 圭次朗, 山口 亮介, 清水 光, 西田 光志, 西川 浩樹
  • Journal Title: 医学と薬学 Volume: 79 Pages: 1469-1477
• [Journal Article] 肝細胞癌との鑑別診断に苦慮した肝内脾症の一例 (2022)
  • Author(s): 杉島 涼音, 大濱 日出子, 西川 浩樹, 安岡 秀高, 横濱 桂介, 後 昴佑, 松井 將太, 西川 知宏, 土本 雄亮, 朝井 章, 福西 新弥, 津田 泰宏, 樋口 和秀
  • Journal Title: 肝臓 Volume: 63 Pages: 456-462
  • Peer Reviewed
• [Journal Article] 臨床上肝原発と考えられたgerminal center B-cell-like typeのびまん性大細胞型B細胞リンパ腫の一例 (2022)
  • Author(s): 大濱 日出子(大阪医科薬科大学 第2内科), 西川 浩樹, 後 昴佑, 松井 將太, 西川 知宏, 中村 憲, 横濱 桂介, 土本 雄亮, 朝井 章, 福西 新弥, 竹下 篤, 津田 泰宏, 樋口 和秀
  • Journal Title: 肝臓 Volume: 63 Pages: 381-387
  • Peer Reviewed
• [Journal Article] 概論 JSHサルコペニア判定基準第2版 判定基準改訂の経緯と解説 (2022)
  • Author(s): 西川 浩樹
  • Journal Title: 肝胆膵 Volume: 85 Pages: 137-144
• [Journal Article] 高齢者肝硬変診療ガイドライン(解説) (2022)
  • Author(s): 名越 澄子, 赤羽 たけみ, 小木曽 智美, 坂牧 僚, 徳本 良雄, 華井 竜徳, 西口 修平, 小川 浩司, 川口 巧, 神田 達郎, 西川 浩樹, 波多野 悦朗
  • Journal Title: 日本高齢消化器病学会誌 Volume: Supplement Pages: 1-55
• [Journal Article] 消化器疾患におけるSARC-F質問票を用いた後方視的比較検討 (2022)
  • Author(s): 松井 將太(大阪医科薬科大学 内科学第II), 西川 浩樹, 後 昴佑, 小倉 健, 竹内 利寿, 後藤 昌弘, 中村 志郎, 柿本 一城, 宮嵜 孝子, 安岡 秀高, 横濱 桂介, 大濱 日出子, 朝井 章, 福西 新弥, 樋口 和秀
  • Journal Title: 日本高齢消化器病学会誌 Volume: 24 Pages: 108-114
  • Peer Reviewed
• [Journal Article] 小学校高学年の児童の生きる力と家庭及び学校における食行動・態度との関連 (2022)
  • Author(s): 脇本景子, 横路三有紀, 大倉健太郎, 岸田恵津
  • Journal Title: 健康教育学会誌 Volume: 30 Pages: 283-292
  • Peer Reviewed
• [Journal Article] Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion (2021)
  • Author(s): Okumura Shintaro、Konishi Yusuke、Narukawa Megumi、Sugiura Yuki、Yoshimoto Shin、Arai Yuriko、Sato Shintaro、Yoshida Yasuo、Tsuji Shunya、Uemura Ken、Wakita Masahiro、Matsudaira Tatsuyuki、Matsumoto Tomonori、Kawamoto Shimpei、Takahashi Akiko、Itatani Yoshiro、Miki Hiroaki ら
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 5674-5674
  • DOI: 10.1038/s41467-021-25965-x
  • Peer Reviewed / Open Access
• [Journal Article] Bioinformatics Analysis of Oral, Vaginal, and Rectal Microbial Profiles during Pregnancy: A Pilot Study on the Bacterial Co-Residence in Pregnant Women (2021)
  • Author(s): Fudaba Megumi、Kamiya Tomonori、Tachibana Daisuke、Koyama Masayasu、Ohtani Naoko
  • Journal Title: Microorganisms Volume: 9 Issue: 5 Pages: 1027-1027
  • DOI: 10.3390/microorganisms9051027
  • Peer Reviewed / Open Access
• [Journal Article] Gut-liver axis-mediated mechanism of liver cancer: A special focus on the role of gut microbiota. (2021)
  • Author(s): Ohtani N and Hara E
  • Journal Title: Cancer Sci Volume: 112 Issue: 11 Pages: 4433-4443
  • DOI: 10.1111/cas.15142
  • Peer Reviewed / Open Access
• [Journal Article] Japan Etiology of Liver Cirrhosis Study Group in the 54th Annual Meeting of JSH. The transition in the etiologies of hepatocellular carcinoma-complicated liver cirrhosis in a nationwide survey of Japan (2021)
  • Author(s): Enomoto H., Ueno Y., Hiasa Y., Nishikawa H., Hige S., Takikawa Y., Taniai M., Ishikawa T., Yasui K., Takaki A., Takaguchi K., Ido A., Kurosaki M., Kanto T., Nishiguchi S
  • Journal Title: J Gastroenterol Volume: 56 Pages: 158-167
  • Peer Reviewed
• [Journal Article] Outcome of nucleos(t)ide analog intervention in patients with preventive or on-demand therapy for hepatitis B virus reactivation. (2021)
  • Author(s): Tamori A, Kimura K., Kioka K., Enomoto H., Odagiri N., Kozuka R., Uchida-Kobayashi S., Enomoto M., Kawada N., Mizokami M
  • Journal Title: J Med Virol. Volume: 93 Pages: 3679-3687
  • NAID: 120007169287
  • Peer Reviewed
• [Journal Article] Predictors for Grip Strength Loss in Patients With Chronic Liver Diseases (2021)
  • Author(s): Nishikawa H., Yoh K., Enomoto H., Ikeda N., Takashima T., Aizawa N., Nishimura T., Nishiguchi S., Iijima H
  • Journal Title: In Vivo Volume: 35 Pages: 363-371
  • Peer Reviewed
• [Journal Article] A New Ultrasonographic "Fluttering Sign" for Hepatic Hemangioma. (2021)
  • Author(s): Kobayashi N., Iijima H., Tada T., Shibata Y., Nishimura T., Kumada T., Hashimoto M., Higashiura A., Yoshida M., Nishimura J., Aizawa N., Ikeda N., Takashima T., Takata R., Nishikawa H., Iwata Y., Enomoto H., Hirota S., Hatano E
  • Journal Title: Ultrasound Med Biol. Volume: 47 Pages: 941-946
  • Peer Reviewed
• [Journal Article] Severity of liver fibrosis using shear wave elastography is influenced by hepatic necroinflammation in chronic hepatitis patients, but not in cirrhotic patients (2021)
  • Author(s): Nakano C., Nishimura T., Tada T., Yoshida M., Takashima T., Aizawa N., Ikeda N., Nishikawa H., Enomoto H., Hatano E., Yano H., Hirota S., Hachiya H., Iijima H
  • Journal Title: Hepatol Res Volume: 51 Pages: 436-444
  • Peer Reviewed
• [Journal Article] Association of the Modified ALBI Grade With Endoscopic Findings of Gastroesophageal Varices (2021)
  • Author(s): Miyamoto Y., Enomoto H., Nishikawa H., Nishimura T., Iwata Y., Nishiguchi S., Iijima H
  • Journal Title: In Vivo Volume: 35 Pages: 1163-1168
  • Peer Reviewed
• [Journal Article] Reduced grip strength is associated with progression of depressive status in chronic liver diseases (2021)
  • Author(s): Nishikawa H., Yoh K., Enomoto H., Ikeda N., Takashima T., Aizawa N., Nishimura T., Nishiguchi S., Iijima H.
  • Journal Title: Ann Palliat Med. Volume: 10 Pages: 3976-3987
• [Journal Article] Combined grip strength and calf circumference as a useful prognostic system in patients with liver diseases: a large cohort study. (2021)
  • Author(s): Nishikawa H., Yoh K., Enomoto H., Nishimura T., Nishiguchi S., Iijima H.
  • Journal Title: Ann Transl Med Volume: 9 Pages: 624-624
  • Peer Reviewed
• [Journal Article] Clinical impact of the finger-circle test in patients with liver diseases (2021)
  • Author(s): Nishikawa H., Yoh K., Enomoto H., Nishimura T., Nishiguchi S., Iijima H.
  • Journal Title: Hepatol Res Volume: 51 Pages: 603-613
  • Peer Reviewed
• [Journal Article] Association of liver stiffness and steatosis with hepatocellular carcinoma development in patients with hepatitis C virus infection who received direct-acting antiviral therapy and achieved sustained virological response (2021)
  • Author(s): Tada T., Nishimura T., Matono T., Yoshida M., Yuri M., Fujiwara A., Yuri Y., Takashima T., Aizawa N., Ikeda N., Enomoto H., Kumada T., Iijima H
  • Journal Title: Hepatol Res Volume: 51 Pages: 860-869
  • Peer Reviewed
• [Journal Article] Factors Associated With Longitudinal QOL Change in Patients With Chronic Liver Diseases (2021)
  • Author(s): Nishikawa H., Yoh K., Enomoto H., Nishimura T., Nishiguchi S., Iijima H
  • Journal Title: In Vivo Volume: 35 Pages: 2451-2456
  • Peer Reviewed
• [Journal Article] Dynapenia Rather Than Sarcopenia Is Associated with Metabolic Syndrome in Patients with Chronic Liver Diseases (2021)
  • Author(s): Nishikawa H., Yoh K., Enomoto H., Nishimura T., Nishiguchi S., Iijima H.
  • Journal Title: Diagnostics Volume: 11 Pages: 1262-1262
  • Peer Reviewed
• [Journal Article] Sarcopenic Obesity in Liver Cirrhosis: Possible Mechanism and Clinical Impact (2021)
  • Author(s): Nishikawa H., Enomoto H., Nishiguchi S., Iijima H
  • Journal Title: Int J Mol Sci. Volume: 22 Pages: 1917-1917
  • Peer Reviewed
• [Journal Article] Relationship Between Social Activity and Frailty in Japanese Older Women During Restriction on Outings due to COVID-19 (2021)
  • Author(s): Michiko Akita, Naoto Otaki, Miyuki Yokoro, Megumu Yano, Norikazu Tanino, Keisuke Fukuo
  • Journal Title: Can Geriatr J. Volume: 24 Issue: 4 Pages: 320-324
  • DOI: 10.5770/cgj.24.507
  • Peer Reviewed / Open Access
• [Journal Article] Associations of serum transthyretin with triglyceride in non-obese elderly Japanese women independently of insulin resistance, HDL cholesterol, and adiponectin (2021)
  • Author(s): Satomi Minato-Inokawa, Ayaka Tsuboi, Mika Takeuchi, Kaori Kitaoka, Megumu Yano, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo
  • Journal Title: Diabetol Int Volume: 12 Issue: 4 Pages: 405-411
  • DOI: 10.1007/s13340-021-00496-4
  • NAID: 40022680865
  • Peer Reviewed / Open Access
• [Presentation] 肥満と肝がん ～Leaky gut による腸内細菌関連物質の肝移行とがん微小環境形成～ (2024)
  • Author(s): 大谷直子
  • Organizer: 49回日本微小循環学会総会
  • Invited
• [Presentation] がん微小環境と腸内細菌 (2024)
  • Author(s): 大谷直子
  • Organizer: 第38回札幌冬季がんセミナー
  • Invited
• [Presentation] Leaky gut による腸内細菌関連物質の肝移行と肝がん微小環境形成 (2024)
  • Author(s): 大谷直子
  • Organizer: 第19回日本がん分子標的治療学会
  • Invited
• [Presentation] Low-speed regular exercise reduces HCC development by muscle PGC1α-mediated kynurenine degradation. (2024)
  • Author(s): Naoko Ohtani, Vu Thuong Huyen, Ryota Yamagishi, Kanae Echizen, Yoshiki Nonaka, Shinji Fukuda
  • Organizer: APASL Kyoto
  • Int'l Joint Research
• [Presentation] Tumor promoting interatome/network analysis during the progression of MASLD/MASH-associated liver cancer model. (2024)
  • Author(s): Yoshiki Nonaka, Atsuki Uno, Kanae Echizen, Yuya Yoshida, Fumiya Sobue, Takahiro Kodama, Naoko Ohtani.
  • Organizer: The 1st International Symposium on Cancer Immunology and Immunotherapy
  • Int'l Joint Research
• [Presentation] Inter-Cellular Network Analysis in Tumor Microenvironment During The Progression of MASLD/MASH-HCC. (2024)
  • Author(s): 59.Yoshiki Nonaka, Atsuki Uno, Kanae Echizen, Yuya Yoshida, Fumiya Sobue, Takahiro Kodama, Naoko Ohtani.
  • Organizer: APASL Kyoto
  • Int'l Joint Research
• [Presentation] Identification of tumor-promoting secreted factors in the progression of steatosis-associated HCC. (2024)
  • Author(s): 60.Atsuki Uno, Yoshiki Nonaka, Kanae Echizen, Ryota Yamagishi, Takahiro Kodama, and Naoko Ohtani
  • Organizer: APASL Kyoto
  • Int'l Joint Research
• [Presentation] The role of senescence-associated secretory phenotype (SASP) in modulating anti-tumor immunity in steatosis-associated liver cancer. (2024)
  • Author(s): Naoko Ohtani
  • Organizer: The 1st International Symposium on Cancer Immunology and Immunotherapy
  • Int'l Joint Research / Invited
• [Presentation] The role and mechanism of SASP in the tumor microenvironment of steatosis-associated liver cancer. (2024)
  • Author(s): Naoko Ohtani
  • Organizer: A3 Foresight Program Kick-off meeting Cellular Senescence: from Pathophysiology to Treatment
  • Int'l Joint Research
• [Presentation] 腸内細菌叢とがん免疫療法 (2023)
  • Author(s): 大谷直子
  • Organizer: 第46回近畿小児血液・がん研究会
  • Invited
• [Presentation] 肝がん微小環境におけるガスダーミンDによるSASP因子の放出とがん進展機構 (2023)
  • Author(s): 大谷直子
  • Organizer: 第46回 日本分子生物学会
• [Presentation] 運動による代謝変化を介したNASH関連肝がん抑制機構 (2023)
  • Author(s): 山岸良多, VU Thuong Huyen, 野中允幾, 越前佳奈恵, 矢野めぐむ, 神谷知憲, 大谷直子
  • Organizer: 第44回日本臨床栄養協会総会 第21回大連合大会
• [Presentation] 肝疾患の病態に基づいた治療戦略 細胞老化・SASPのがん微小環境における役割とそれを標的とするセノセラピー (2023)
  • Author(s): 大谷直子
  • Organizer: 第31回日本消化器関連学会週間（JDDW）
• [Presentation] 腸内細菌叢と肥満関連肝がん～腸内細菌関連物質の肝移行によるがん微小環境形成～ (2023)
  • Author(s): 大谷直子
  • Organizer: 千里ライフサイエンスセミナーⅤ３ 第９回がんシリーズ
  • Invited
• [Presentation] 肥満誘導性肝臓がん微小環境における様々ながん促進的経路に着目した機能的インタラクトーム解析(Functional interactome analysis in various tumor-promoting pathways in obesity-associated liver tumor microenvironment) (2023)
  • Author(s): 大谷直子
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 肥満誘導性肝がん微小環境におけるがん進展過程を考慮したネットワーク解析(Tumor-promoting interactome/network analysis during the progression of NAFLD/NASH-associated liver cancer model) (2023)
  • Author(s): 野中 允幾, 宇野 敦葵, 越前 佳奈恵, 山岸 良多, 大谷 直子
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 肝がん微小環境におけるSASP因子放出の分子メカニズムと肝がんの進展機構の解明(Molecular mechanism of SASP factor release in liver tumor microenvironment and hepatocellular carcinoma progression) (2023)
  • Author(s): 山岸 良多, 蒲池 史卓, 河田 則文, 原 英二, 大谷 直子
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 研究と子育てを両立させる作戦 インフォマティクス解析を取り入れた研究スタイル (2023)
  • Author(s): 越前佳奈恵 大谷直子
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 腸内細菌が関わる肝発癌と免疫応答(Commensal bacteria and tumor immunity Hepatic Carcinogenesis and Immune Response Involving Gut microbial metabolites) (2023)
  • Author(s): 山岸 良多, 蒲池 史卓, 程 イ, 河田 則文, 原 英二, 大谷 直子
  • Organizer: 第82回日本癌学会学術総会
• [Presentation] 非アルコール性脂肪肝疾患関連肝がんにおける細胞傷害性T細胞の肝臓への遊走メカニズムと治療への応用 (2023)
  • Author(s): 神谷 知憲, 藤井 英樹, 武藤 芳美, 河田 則文, 大谷 直子
  • Organizer: 第27回日本がん免疫学会総会
• [Presentation] 肝がん微小環境における細胞老化・SASPの役割とその制御～SASP因子放出のメカニズム～ (2023)
  • Author(s): 大谷直子
  • Organizer: 第31回 日本Cell Death学会
• [Presentation] 腸内細菌叢と肝がん (2023)
  • Author(s): 大谷直子
  • Organizer: 日本乳酸菌学会 2023 年度大会 BMFH セミナー
• [Presentation] IL-33によるNASH関連肝がん促進機構の解明 (2023)
  • Author(s): 山岸良多、大谷直子
  • Organizer: 第27回日本がん分子標的治療学会学術集会
• [Presentation] 規則的な運動はオンコメタボライトKynurenineを減少させることで肥満誘導性肝がんの進展を抑制する (2023)
  • Author(s): ヴ トゥン フェン、山岸良多、大谷直子
  • Organizer: 第27回日本がん分子標的治療学会学術集会
• [Presentation] がん微小環境における細胞老化・SASPの役割とその制御 (2023)
  • Author(s): 大谷直子
  • Organizer: 第23回抗加齢医学会総会
• [Presentation] 細胞老化とＳＡＳＰ：その誘導機構とがん微小環境における役割 (2023)
  • Author(s): 大谷直子
  • Organizer: 第96回日本内分泌学会学術総会
  • Invited
• [Presentation] 規則的な運動による代謝変化とがん抑制 (2023)
  • Author(s): 大谷直子
  • Organizer: 第9回 がんと代謝研究会 in 松山
• [Presentation] 腸内細菌叢と肝がん (2023)
  • Author(s): 大谷直子
  • Organizer: 第31回日本医学会総会
• [Presentation] Gut-liver axis-mediated mechanism of NASH(MASH)-associated hepatocellular carcinoma progression. (2023)
  • Author(s): Naoko Ohtani
  • Organizer: The 3rd JSH International Liver Conference
  • Int'l Joint Research / Invited
• [Presentation] Gut-liver Axis-Mediated Mechanism of Obesity-Associated Hepatocellular Carcinoma Progression. (2023)
  • Author(s): Naoko Ohtani
  • Organizer: The 2nd JCA-AACR Precision Cancer Medicine International Conference
  • Int'l Joint Research / Invited
• [Presentation] 消化器病患者における握力低下に関連する因子の検討 (2023)
  • Author(s): 松井 將太, 浅石 健, 大西 沙央莉, 後 昴佑, 横濱桂介, 朝井 章, 福西 新弥, 西川 浩樹
  • Organizer: 第109回日本消化器病学会総会
• [Presentation] Sequential療法後のHBs抗原消失に関する検討 (2023)
  • Author(s): 榎本平之、由利幸久, 飯島尋子
  • Organizer: 第109回日本消化器病学会総会
• [Presentation] C 型非代償性肝硬変の DAA 治療：現状と課題 (2023)
  • Author(s): 由利幸久、榎本平之、飯島尋子
  • Organizer: 第109回日本消化器病学会総会
• [Presentation] Sequential療法のHBsAg消失と栄養評価指数との関連についての検討 (2023)
  • Author(s): 榎本平之、会澤信弘、岡本麻美子、吉原公平、吉岡亮太、川田翔己、由利幸久、髙嶋智之、池田直人、塩見英之、福西新弥、飯島尋子、西村貴士
  • Organizer: 第45回回日本肝臓学会西部会
• [Presentation] Hepatoma-derived growth factor(HDGF)の肝癌増殖における役割の検討：治療標的の可能性について (2023)
  • Author(s): 榎本平之
  • Organizer: 第27回日本肝臓学会大会
• [Presentation] Identification of the possible target genes of hepatoma-derived growth factor in hepatoma cells, (2023)
  • Author(s): Enomoto H., Nakamura H., Aizawa N., Takashima T., Ikeda N., Yuri Y., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Kawase Y., Nakano R., Shiomi H., Iijima H
  • Organizer: APASL Oncology
• [Presentation] Hepatoma-derived growth factor as a possible target gene for the treatment of HCC The Asian Pacific Association for the Study of the Liver (2023)
  • Author(s): Enomoto H., Nishikawa H., Nakamura H., Fukunishi S., Shiomi H., Iijima H
  • Organizer: APASL
• [Presentation] Non-heat-stressed method to isolate hepatic stellate cells from highly steatotic tumor-bearing liver usingCD49a (2023)
  • Author(s): Yi Cheng, Ryota Yamagishi, Yoshiki Nonaka, Misako Sato-Matsubara, Norifumi Kawada, and Naoko Ohtan
  • Organizer: The 32nd Conference of the Asian Pacific Association Study of the Liver(APASL2023)
• [Presentation] 腸内細菌叢と肥満関連肝がん; ～Leaky gutによる腸内細菌関連物質の肝移行の関与～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第26回腸内細菌学会学術集会 シンポジウム2：マイクロバイオームの制御と健康
• [Presentation] 肥満と肝がん;腸内細菌叢成分による肝がん促進的微小環境の形成 (2022)
  • Author(s): 大谷直子
  • Organizer: 第8回がんと代謝研究会 in 佐渡
• [Presentation] ガレクチン３による骨格筋内異所性脂肪の形成促進; ～シングルセル解析を利用した分化異常の検出～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第8回日本筋学会学術集会 シンポジウム7：健康長寿の実現に向けたサルコペニア／フレイル研究の新展開
• [Presentation] 肥満による肝がんの進展メカニズム ～腸内細菌関連因子の関与～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第2回バイオインダストリー協会 機能性食品研究会講演会
• [Presentation] Hepatic transfer of gut microbial component promotes obesity-associated liver cancer progression (2022)
  • Author(s): Naoko Ohtani
  • Organizer: 日本学術振興会主催の第23回北東アジアシンポジウム（テーマ：細胞老化）
  • Int'l Joint Research / Invited
• [Presentation] The role of hepatic stellate cells in tumor microenvironment of obesity-associated liver cancer (2022)
  • Author(s): Naoko Ohtani
  • Organizer: The 2nd Osaka Metropolitan University International Liver Forum
  • Int'l Joint Research / Invited
• [Presentation] Hepatic transfer of gut microbial component promotes obesity-associated liver cancer progression (2022)
  • Author(s): Naoko Ohtani
  • Organizer: 第81回日本癌学会学術総会Symposium 5 Metabolic alteration in the Tumor microenvironment
• [Presentation] 細胞老化とＳＡＳＰ：その誘導機構とがん微小環境における役割 (2022)
  • Author(s): 大谷直子
  • Organizer: 第48回日本臓器保存生物医学会学術集会
  • Invited
• [Presentation] Obesity-associated liver cancer: the role of hepatic translocation of gut microbial factors (2022)
  • Author(s): Naoko Ohtani
  • Organizer: IHMC KOBE 2022 The International Human Microbiome Consortium Congress
  • Int'l Joint Research / Invited
• [Presentation] The role and mechanism of SASP in tumor microenvironment of obesity-associated liver cancer (2022)
  • Author(s): Naoko Ohtani
  • Organizer: The 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
  • Int'l Joint Research / Invited
• [Presentation] 肥満と肝がん ～腸内細菌関連物質の肝移行とがん微小環境形成～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第35回 日本バイオセラピィ学会学術集会総会モーニングセミナー
  • Invited
• [Presentation] 腸内細菌叢と肥満関連肝がん～Leaky gutによる腸内細菌関連物質の肝移行の関与～ (2022)
  • Author(s): 大谷直子
  • Organizer: 第54回無菌生物ノートバイオロジー学会 シンポジウム 「常在細菌と宿主免疫の新たな展開」
  • Invited
• [Presentation] Gut-liver Axis-Mediated Mechanism of Obesity-Associated Hepatocellular Carcinoma Progression (2022)
  • Author(s): Naoko Ohtani
  • Organizer: Asian Pacific Association for the Study of the Liver (APASL) 2023
  • Int'l Joint Research / Invited
• [Presentation] Intestinal microbiome and liver cancer (2022)
  • Author(s): Naoko Ohtani
  • Organizer: USJCMSP 2023 International Conference on Emerging Infectious Diseases Cancer Panel
  • Int'l Joint Research / Invited
• [Presentation] 比較生物学的アプローチから示される加齢にともなう遺伝子発現変化とその生体における有益性 (2022)
  • Author(s): 吉田優矢、高杉征樹、野中允幾、大谷直子
  • Organizer: NGS EXPO 2022
• [Presentation] 加齢にともなう遺伝子発現変化は長寿の指標として有益なものである：比較生物学的アプローチより (2022)
  • Author(s): 吉田優矢、高杉征樹、野中允幾、大谷直子
  • Organizer: 第45回日本分子生物学会年会
• [Presentation] IL-33によるNASH関連肝がん促進機構 (2022)
  • Author(s): 山岸良多、武藤芳美、河田則文、大谷直子
  • Organizer: 第59回日本肝臓学会総会
• [Presentation] IL-33released from senescent hepatic stellate cell promotes obesity-associated hepatocellular carcinoma (2022)
  • Author(s): Ryota Yamagishi, Fumitaka Kamachi, Tomonori Kamiya, Yi Cheng, Yoshiki Nonaka, Norifumi Kawada, Susumu Nakae, Eiji Hara, Naoko Ohtani
  • Organizer: APASL Oncology 2022 Single Topic conference in Takamatsu
• [Presentation] IL-33released from senescent hepatic stellate cell promotes obesity-associated hepatocellular carcinoma (2022)
  • Author(s): Ryota Yamagishi, Fumitaka Kamachi, Yi Cheng, Norifumi Kawada, Eiji Hara, Naoko Ohtani
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] がん微小環境における細胞老化とSASPの役割：ガスダーミンDを介するSASP因子の放出が肥満関連肝がんを促進させる (2022)
  • Author(s): 山岸良多、蒲池史卓、神谷知憲、高杉征樹、程禕、野中允幾、河田則文、中江進、原英二、大谷直子
  • Organizer: 日本生理学会第100回記念大会
• [Presentation] Regular exercise suppresses obesity associated liver cancer through activating Pgc-1α-Kynurenine degrading pathway (2022)
  • Author(s): Vu Thuong Huyen, Ryota Yamagishi, Naoko Ohtani
  • Organizer: APASL Oncology 2022 Single Topic conference in Takamatsu
• [Presentation] Regular exercise suppresses obesity associated liver cancer through activating Pgc-1α-Kynurenine degrading pathway (2022)
  • Author(s): Vu Thuong Huyen, Ryota Yamagishi, Naoko Ohtani
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] 肥満誘導性肝がん微小環境における腫瘍促進ネットワークの複合バイオインフォマティクス解析 (2022)
  • Author(s): 野中允幾、山岸良多、程禕、大谷直子
  • Organizer: 第81回日本癌学会学術総会(横浜）
• [Presentation] Combined Bioinformatics on the Tumor Promoting Inter-cellular Network in Obesity-associated Liver Tumor Microenvironment (2022)
  • Author(s): Yoshiki Nonaka, Ryota Yamagishi, Yi Cheng, Naoko Ohtani
  • Organizer: APASL Oncology 2022 Single Topic conference in Takamatsu
• [Presentation] 肥満誘導性肝がん微小環境における腫瘍促進ネットワークの複合解析 (2022)
  • Author(s): 野中允幾、山岸良多、程禕、小玉尚宏、大谷直子
  • Organizer: NGS EXPO 2022
• [Presentation] 肝性脳症発症に関わる腸内細菌の同定 (2022)
  • Author(s): 神谷知憲，武藤芳美，藤井英樹，森宙史，豊田敦，福田真嗣，河田則文，大谷直子
  • Organizer: 第26回腸内細菌学会学術集会
• [Presentation] Non-heat-stressed method to isolate hepatic stellate cells from highly steatotic tumor-bearing liver usingCD49a (2022)
  • Author(s): Yi Cheng, Ryota Yamagishi, Yoshiki Nonaka, Misako Sato-Matsubara, Norifumi Kawada, and Naoko Ohtani
  • Organizer: THE LIVER SINUSOID MEETING,21st ISCHS Meeting
• [Presentation] Identification and characterization of the gut microbial species responsible for hyperammonemia in hepatic encephalopathy from the analysis of patients administered rifaximin (2022)
  • Author(s): Yoshimi Yukawa-Muto, Tomonori Kamiya, Norifumi Kawada, Naoko Ohtani
  • Organizer: IHMC KOBE 2022～The International Human Microbiome Consortium Congress～
• [Presentation] Rifaximin治療効果に基づく肝性脳症原因菌の同定とメカニズムの解明 (2022)
  • Author(s): 武藤（湯川）芳美，河田則文，大谷直子
  • Organizer: 日本消化器関連学会週間（JDDW）ワークショップ「消化器疾患とマイクロバイオーム研究の新展開」
• [Presentation] 肝性脳症における腸内細菌叢ーリファキリミン非著効例における菌種の機能解析ー (2022)
  • Author(s): 武藤芳美，河田則文，大谷直子
  • Organizer: 第108回日本消化器病学会総会 ワークショップ1
• [Presentation] 肝性脳症発症に関わる腸内細菌の探索 (2022)
  • Author(s): 武藤芳美、神谷知憲、小田桐直志、小谷晃平、元山宏行、川村悦史、萩原淳司、藤井英樹、打田佐和子、榎本大、河田則文、大谷直子
  • Organizer: 第29回日本門脈圧亢進症学会総会 パネルディスカッション3
• [Presentation] Hepatoma-derived growth factor (HDGF) の肝癌増殖における役割の検討 (2022)
  • Author(s): 榎本平之、中村秀次、飯島 尋子
  • Organizer: 第108回 日本消化器病学会総会ワークショップ10:肝疾患の遺伝子解析による病態解明と臨床展開
• [Presentation] HBV感染者の線維化と発がんにおける生活習慣関連因子の関連についての検討 (2022)
  • Author(s): 榎本平之、会澤信弘、飯島 尋子
  • Organizer: 第58回日本肝臓学会総会シンポジウム1: ウイルス性肝疾患の完全克服とマネジメント
• [Presentation] 肝硬変の生活の質に関する検討：サルコペニアとの関連について (2022)
  • Author(s): 榎本平之、楊和典、飯島 尋子
  • Organizer: 第26回日本肝臓学会大会シンポジウム 5：肝硬変診療ガイドライン改訂後の診療と研究
• [Presentation] A high expression of SHROOM4 was associated with a favorable prognosis in HCC patients (2022)
  • Author(s): Enomoto H., Nishimura T., Aizawa N., Takashima T., Ikeda N., Yuri Y., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Iijima H
  • Organizer: APASL Oncology 2022
  • Int'l Joint Research
• [Presentation] Etiological transitions in patients with liver cirrhosis and hepatocellular carcinoma: a single-center study from an institution located in a district with a high prevalence of viral hepatitis (2022)
  • Author(s): Enomoto H., Takashima T., Nishimura T., Aizawa N., Ikeda N., Yuri Y., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Iijima H
  • Organizer: APASL Oncology 2022
  • Int'l Joint Research
• [Presentation] Hepatoma-derived growth factor as a potential target molecule for the treatment of hepatocellular carcinoma (2022)
  • Author(s): Enomoto H
  • Organizer: The Asian Pacific Association for the Study of the Liver Single Topic Conference
  • Int'l Joint Research
• [Presentation] Induction of the SHROOM4 gene as a possible negative feedback response to hepatoma-derived growth factor (2022)
  • Author(s): Enomoto H., Aizawa N., Takashima T., Ikeda N., Yuri Y., Okamoto M., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Iijima H
  • Organizer: The 73rd Annual Meeting of the American Association for the Study of Liver Diseases
  • Int'l Joint Research
• [Presentation] Correlation of Renal Function and Muscle Mass in Young Athletes (2022)
  • Author(s): Osamu Yasuda, Hisayo Yasuda, Mitsuru Ohishi
  • Organizer: International Society of Hypertension
  • Int'l Joint Research
• [Presentation] 腸内細菌叢と肝がん (2021)
  • Author(s): 大谷直子
  • Organizer: 第21回日本抗加齢医学会総会 シンポジウム11
  • Invited
• [Presentation] Gut microbial metabolites and liver cancer (2021)
  • Author(s): Naoko Ohtani
  • Organizer: The European Association for the Study of the Liver (EASL), International Liver Congress “Metabolism and cancer” Online
  • Int'l Joint Research / Invited
• [Presentation] 腸肝軸を介した腸内細菌成分による肝がん促進的微小環境の形成 (2021)
  • Author(s): 大谷直子
  • Organizer: 第25回日本がん免疫学会総会シンポジウム
  • Invited
• [Presentation] 腸内細菌叢と肝疾患～肝性脳症～ (2021)
  • Author(s): 大谷直子
  • Organizer: 第４８回日本毒性学会学術年会 シンポジウム マイクロバイオームの最先端
  • Invited
• [Presentation] Gut-liver axis-mediated mechanism of NASH-associated hepatocellular carcinoma progression (2021)
  • Author(s): Ryota Yamagishi, Fumitaka Kamachi, Tomonori Kamiya, Yoshiki Nonaka, Yoshimi Muto-Yukawa, Norifumi Kawada, Susumu Nakae, Eiji Hara and Naoko Ohtani.
  • Organizer: The Asian Pacific Association for the Study of the Liver (APASL)
  • Int'l Joint Research
• [Presentation] The Role of Gut Microbiota in Obesity-associated Liver Cancer development. (2021)
  • Author(s): Naoko Ohtani, Fumitaka Kamachi, Tomonori Kamiya and Ryota Yamagishi.
  • Organizer: The 80th Annual meeting of JCA（日本癌学会学術総会）, Symposium 12 Metabolism in Cancer.
  • Invited
• [Presentation] 複合オミックス解析によるサルコペニア肥満における骨格筋内異所性脂肪形成の起源及び誘因の解明 (2021)
  • Author(s): 高田 尚輝、高杉 征樹、野中 允幾、神谷 知憲、武村 和明、佐藤 淳子、伊藤 慎二、中村 博亮、上住 聡芳、大谷 直子
  • Organizer: 第36回日本整形外科学会基礎学術集会
• [Presentation] 細胞老化とSASP：その誘導機構と生体における役割 (2021)
  • Author(s): 大谷直子
  • Organizer: 第53回日本動脈硬化学術集会・総会 シンポジウム３：老化と代謝
  • Invited
• [Presentation] The role of gut microbiota in obesity-associated liver cancer development (2021)
  • Author(s): Naoko Ohtani
  • Organizer: The 50th Annual Meeting of the Japanese Society for Immunology（日本免疫学会学術集会）, Symposium SY-1 Systemic organ interactions in health and disease
  • Invited
• [Presentation] The role and mechanism of SASP in tumor microenvironment of obesity-associated liver cancer. (2021)
  • Author(s): Naoko Ohtani
  • Organizer: The 6th International Cell Senescence Assciation (ICSA) Confetence,
  • Int'l Joint Research / Invited
• [Presentation] 肥満と肝がん ～腸内細菌関連物質の肝移行とがん微小環境形成～ (2021)
  • Author(s): 大谷直子
  • Organizer: 第42回日本肥満学会・第39回日本肥満症治療学会学術集会 シンポジウム6：肥満とがん ―分子メカニズムから疫学まで
  • Invited
• [Presentation] Gut-liver axis-mediated mechanism of SASP in tumor microenvironment of obesity-associated liver cancer (2021)
  • Author(s): Naoko Ohtani
  • Organizer: Keystone Symposia, “Cancer: Aging on the Drivber’s seat”
  • Int'l Joint Research / Invited
• [Presentation] Sequential療法のHBs抗原とHBcr抗原低下に関する検討 (2021)
  • Author(s): 榎本平之、西口修平、飯島尋子
  • Organizer: 第107回日本消化器病学会シンポジウム9 ：肝発癌抑制を目指したB型肝炎の最新治療）
• [Presentation] 慢性肝疾患患者における握力の低下はうつ状態増悪の危険因子である (2021)
  • Author(s): 西川浩樹、榎本平之、飯島尋子
  • Organizer: 第107回日本消化器病学会総会ワークショップ7：消化器疾患とサルコペニア：診断，治療と予後）
• [Presentation] Sequential療法の治療効果関連因子に関する検討. (2021)
  • Author(s): 榎本平之、西口修平、飯島尋子
  • Organizer: 第57回日本肝臓学会総会シンポジウム2 ： B型肝炎ウイルス診療の現状と課題）
• [Presentation] 抗ウイルス療法の治療効果と肝発がんに関する検討. (2021)
  • Author(s): 榎本平之、西口修平、飯島尋子
  • Organizer: 第44回日本肝臓学会西部会シンポジウム3：HBs 抗原消失，肝発がん抑制を目指した B 型肝炎治療の現状と展開）
• [Presentation] サルコペニア・肝硬変の要素と健康関連QOL・精神状態の関連性について. (2021)
  • Author(s): 楊和典、榎本平之
  • Organizer: 第44回日本肝臓学会西部会シンポジウム 5：肝疾患における臓器連関の役割）
• [Presentation] C型肝炎ウイルスSVR後の、食道胃静脈瘤の長期経過に関する検討. (2021)
  • Author(s): 由利幸久、榎本平之、飯島尋子
  • Organizer: 第44回日本肝臓学会西部会シンポジウム 6：門脈圧亢進症の病態評価と可逆性・不可逆性）
• [Presentation] 自己免疫性肝炎軽症例の治療とMAFLD影響 (2021)
  • Author(s): 会澤信弘、榎本平之、飯島尋子
  • Organizer: 第44回日本肝臓学会西部会シンポジウム 6：門脈圧亢進症の病態評価と可逆性・不可逆性
• [Presentation] 自己免疫性肝炎軽症例の治療とMAFLD影響 (2021)
  • Author(s): 会澤信弘、榎本平之、飯島尋子
  • Organizer: 第44回日本肝臓学会西部会シンポジウム 9：自己免疫性肝疾患の温故知新
• [Presentation] がん細胞を取り巻く微小環境の重要性 担癌モデル実験からの学び (2021)
  • Author(s): 榎本平之、西口修平、飯島尋子
  • Organizer: 第44回日本肝臓学会西部会シンポジウム10：がん微小環境と肝細胞癌の発癌・進展機構
• [Presentation] Possible association of ZNF641 with the prognosis of hepatocellular carcinoma. (2021)
  • Author(s): Enomoto H., Takashima T., Aizawa N., Ikeda N., Yuri Y., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Iijima H
  • Organizer: The 72nd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD2021)
  • Int'l Joint Research
• [Presentation] Possible involvement of ZNF641 with the prognosis of hepatocellular carcinoma. (2021)
  • Author(s): Enomoto H., Takashima T., Aizawa N., Ikeda N., Yuri Y., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Iijima H.
  • Organizer: The Asian Pacific Association for the Study of the Liver Single Topic Conference
  • Int'l Joint Research
• [Presentation] Hepatoma-derived growth factor as a potential target molecule for the treatment of hepatocellular carcinoma. (2021)
  • Author(s): Enomoto H., Takashima T., Aizawa N., Ikeda N., Yuri Y., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Iijima H
  • Organizer: JSH International Liver Conference 2021
  • Int'l Joint Research
• [Presentation] Hepatoma-derived growth factor as a potential therapeutic target for hepatocellular carcinoma. (2021)
  • Author(s): Enomoto H., Nakamura H., Takashima T., Aizawa N., Ikeda N., Yuri Y., Fujiwara A., Yoshihara K., Yoshioka R., Kawata S., Ota S., Nakano R., Shiomi H., Nishimura T., Nishiguchi S., Iijima H
  • Organizer: APASL Oncology 2021
  • Int'l Joint Research
• [Book] Recent Advances in the Diagnosis and Treatment of Chronic Liver Diseases (2022)
  • Author(s): Enomoto H
  • Total Pages: 112
  • Publisher: MDPI Open Access Books
  • ISBN: 9783036529936