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Understanding the effects of substrate stiffness on rejuvenation of aging MSCs via single cell analysis.

Research Project

Project/Area Number 21K12686
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90120:Biomaterials-related
Research InstitutionKyushu University

Principal Investigator

久保木 タッサニーヤー  九州大学, 先導物質化学研究所, 助教 (20526834)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMSC aging / mechano-regulation / substrate stiffness / redox balance / single cell analysis
Outline of Research at the Start

The key question for this proposal is how the substrate stiffness could maintain the MSC quality and delay the aging. The central hypothesis is that the compliance substrates could reduce CSKs tension, increase their dynamics and the activate the antioxidant system to maintain the redox homeostasis. Increasing of aging population and aged-related diseases increase the health problems. Identification of key targets for preventing or ameliorating senescence is essential for precisely engineered mechanical substrate to slow or reverse the age-related reduction of MSC properties.

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Published: 2021-04-28   Modified: 2021-08-30  

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