Probe-type nanowire sensor for label-free, in-situ, ultrasensitive detection of biomarkers from single cell in adherent culture

• Project/Area Number: 21K14653
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 34020:Analytical chemistry-related
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: 毛 思鋒 東京都立大学, 都市環境科学研究科, 助教 (40885315)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2021)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: Microfluidics / nanowire / biosensor / Cell research / biomarker

Outline of Research at the Start

In this proposal, we aim to develop probe-type nanowire sensor for label free, in-situ, ultrasensitive detection of biomarkers from single cell in adherent culture. It might be a general strategy for molecule detection if we functionalized the nanowire with different types of receptors.