• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biomolecule compartmentalization by phase separated protocells

Research Project

Project/Area Number 21K14746
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
Research InstitutionTokyo Institute of Technology

Principal Investigator

ジャー トニーズィ  東京工業大学, 地球生命研究所, 特任助教 (10800328)

Project Period (FY) 2021-04-01 – 2023-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsOrigins of Life / Protocell / Prebiotic Chemistry / Astrobiology / Phase Separation
Outline of Research at the Start

Membraneless droplets generated by liquid-liquid phase separation (LLPS) were likely protocells. However, their structures and functions are unclear. We propose to study assembly, structure, and function of membraneless protocell compartments such as polyester droplets and liquid crystal coacervates. By probing the ability of LLPS protocells to stably compartmentalize and protect biomolecules and connecting these to essential modern cellular functions, we hope to understand more about how primitive protocells and chemistries directly evolved into modern cells and biologies.

URL: 

Published: 2021-04-28   Modified: 2021-08-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi