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Exploring the functional role of Hijiki in obesity-associated to sphingolipid metabolism

Research Project

Project/Area Number 21K14812
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 38050:Food sciences-related
Research InstitutionHokkaido University

Principal Investigator

BommeGowda SiddabasaveGowda  北海道大学, 保健科学研究院, 講師 (50800504)

Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2024: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsHijiki / Obesity / Sphingolipid metabolism
Outline of Research at the Start

(1) Isolate and characterize the chemical constituent of Hijiki responsible for SMS inhibition. (2) Determination of its IC50 and mode of action on the lipid droplet formation by cell-based assay (3) Revealing the in vitro effects by analysis of altered cellular lipid biomarkers by LC-MS (4) Elucidate the in vivo effects by oral administration of the active constituent of
Hijiki using High-fat diet mouse model.

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Published: 2021-04-28   Modified: 2021-08-30  

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