Discovery and characterization of a pressure sensation and transduction (PREST) mechanism in the presynaptic terminal in the CNS.

Research Project

Project/Area Number	21K15203
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 46030:Function of nervous system-related
Research Institution	The University of Tokyo
Principal Investigator	UCAR HASAN 東京大学, ニューロインテリジェンス国際研究機構, 特任助教 (50748423)
Project Period (FY)	2021-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2021)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2025: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2024: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2023: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords	Synaptic plasticity / Spine enlargement / Presynaptic terminal / SNARE assembly / Glutamate release
Outline of Research at the Start	Using 2-photon and STED-microscopy I will study the molecular mechanisms of our novel finding of the pressure sensation and transduction (PREST) mechanism in the presynaptic terminal in the brain.