|Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|Outline of Research at the Start
Fear learning is important for animals to survive in environments filled with danger. Critically, when sensory events occur which are related, organisms perform a form of inference to determine whether those stimuli should be feared. To study the neural mechanism underlying emotional inference, a behavioral model in rats will be developed. Calcium imaging will be used to detect neural activity in amygdala and mPFC. Optogenetics will be applied to inactivate mPFC and its projections to amygdala. This study is vitally important for understanding and potentially treating human anxiety disorders.