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Development of a novel antimicrobial capable of selectively killing Shiga toxin-producing Escherichia coli

Research Project

Project/Area Number 21K15436
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 49050:Bacteriology-related
Research InstitutionJichi Medical University

Principal Investigator

ティティアナンパコーン・カネート  自治医科大学, 医学部, ポスト・ドクター (20882806)

Project Period (FY) 2021-04-01 – 2023-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsEHEC / CRISPR-Cas13a / Bacteriophage
Outline of Research at the Start

We will establish the new therapy for specific killing of EHEC infection together with suppression of Shiga toxin expression by designing CRISPR-Cas13a that recognizes stx genes, synthesizing antibacterial capsids, and verifying the cytotoxic and therapeutic effect of antibacterial capsids .

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Published: 2021-04-28   Modified: 2021-08-30  

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