|Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|Outline of Research at the Start
Mice deficient of Sipa1, which encodes Rap1 GTPase-activating protein, showed significantly increased resistance to different cancer cells with increased host stromal reactions. While Sipa1 deficiency uncovered a host immune mechanism potentially capable of eradicating cancer cells via coordinated interplay between mesenchymal stromal cells (MSCs) and immune T cells, the detail mechanism has not been demonstrated. This research is to clarify the biological significance of stromal reactions in cancer tissue microenvironment and to develop a new therapeutic strategy for cancer immunotherapy.