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The mechanism of resistance to cancer uncovered by Sipa1 deficiency

Research Project

Project/Area Number 21K15466
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 49070:Immunology-related
Research InstitutionKyoto University

Principal Investigator

徐 彦  京都大学, 医学研究科, 特定助教 (00896631)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsMSCs / Tumor microenvironment / Cancer immunotherapy / Sipa1
Outline of Research at the Start

Mice deficient of Sipa1, which encodes Rap1 GTPase-activating protein, showed significantly increased resistance to different cancer cells with increased host stromal reactions. While Sipa1 deficiency uncovered a host immune mechanism potentially capable of eradicating cancer cells via coordinated interplay between mesenchymal stromal cells (MSCs) and immune T cells, the detail mechanism has not been demonstrated. This research is to clarify the biological significance of stromal reactions in cancer tissue microenvironment and to develop a new therapeutic strategy for cancer immunotherapy.

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Published: 2021-04-28   Modified: 2021-08-30  

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