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CRISPR/Cas9-mediated genome-editing of long-term hematopoietic stem cells

Research Project

Project/Area Number 21K15872
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionJichi Medical University

Principal Investigator

スブド ビャンバー  自治医科大学, 医学部, 助教 (90834193)

Project Period (FY) 2021-04-01 – 2023-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsCRISPR/Cas9 / Hematopoietic stem cell / SCID / NHEJ / HDR
Outline of Research at the Start

In the proposed study, I will develop HDR-edited long-term HSC for autologous transplantation to cure X-SCID in the mice. In the future, this approach can be easily converted to the genome-editing of human true HSC and translate to the large animal study.

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Published: 2021-04-28   Modified: 2021-08-30  

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