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Different roles of C/EBP-alpha in chromosome conformation during lung injury of young and old mice

Research Project

Project/Area Number 21K16142
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionKyoto University

Principal Investigator

Gothwal Santosh・Kumar  京都大学, 医学研究科, 研究員 (80870526)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsC/EBP-alpha / lung homeostasis / chromosomes conformation / CCAAT enhancer / Cohesin
Outline of Research at the Start

During lung injury, the emergent gene expression in AT2 cells is required for lung homeostasis. What mechanisms regulate the emergent gene expression lung homeostasis is elusive. C/EBPa is specific transcriptional factor known to regulate the emergent gene expression in AT2 cell.

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Published: 2021-04-28   Modified: 2021-08-30  

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