Different roles of C/EBP-alpha in chromosome conformation during lung injury of young and old mice

Research Project

Project/Area Number	21K16142
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 53030:Respiratory medicine-related
Research Institution	Kyoto University
Principal Investigator	Gothwal Santosh・Kumar 京都大学, 医学研究科, 研究員 (80870526)
Project Period (FY)	2021-04-01 – 2024-03-31
Project Status	Granted (Fiscal Year 2021)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	C/EBP-alpha / lung homeostasis / chromosomes conformation / CCAAT enhancer / Cohesin
Outline of Research at the Start	During lung injury, the emergent gene expression in AT2 cells is required for lung homeostasis. What mechanisms regulate the emergent gene expression lung homeostasis is elusive. C/EBPa is specific transcriptional factor known to regulate the emergent gene expression in AT2 cell.