Creation of cell response control method by electric charge -Cure viral infection and cancer with charged hydrogel

• Project/Area Number: 21K19878
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 90:Biomedical engineering and related fields
• Research Institution: Hokkaido University
• Principal Investigator: Tanaka Shinya 北海道大学, 医学研究院, 教授 (70261287)
• Project Period (FY): 2021-07-09 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: ハイドロゲル / ウイルス感染 / がん幹細胞 / ウイルス

Outline of Research at the Start

医学の領域で感染症・がんは2大疾患であり、これらをわが国の科学力を持って制御することは喫緊の課題である。我々は最近、バイオマテリアルの１つであるハイドロゲルがヒト細胞に急速なゲノム変化を誘導することを見出した（Nat. Biomed. Eng, 2021）。本研究はこの技術を格段に発展させ、これまでにない斬新な発想で、細胞周囲の荷電状態を変化させることで細胞のゲノム状態を制御し、ウイルスへの感染を防御し、また、がん幹細胞を誘導することで、がんの早期診断法およびがん幹細胞特異的治療薬を開発する。最終的には、再生医療、未来医療を学術的に支える新学問領域「マテリアルゲノミクス」の確立を目指す。

Outline of Final Research Achievements

Infectious diseases and cancer are two major diseases, and their control is an urgent issue. We recently found that hydrogels induce rapid genomic changes in human cells (Nat. Biomed. Eng, 5, 914-925, 2021). In this research, this technology has been significantly developed, and the genomic state of cells was controlled by changing the charge (charge state) around cells using hydrogels. We found a charge condition that promoted viral proliferation and a charge condition that maximized the expression of cancer stem cell markers. This reveals the importance of specific pericellular charges in virus propagation and cancer stem cell creation.

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、ウイルス増殖及びがん幹細胞の創出において、細胞周囲の特定のチャージ（荷電状態）が重要であることが明らかとなった。これらをコントロールすることで、ウイルス感染防御及びがん幹細胞標的治療法開発に繋がると期待される。 最終的には、再生医療、未来医療を学術的に支える新学問領域「マテリアルゲノミクス」の確立に繋がるものであり、社会的・学問的意義が大きい。

Research Products

• [Int'l Joint Research] University Hospital Magdeburg(ドイツ)
• [Journal Article] Geometrical analysis identified morphological features of hydrogel-induced cancer stem cells in synovial sarcoma model cells (2023)
  • Author(s): Ferdous Zannatul、Clement Jean-Emmanuel、Gong Jian Ping、Tanaka Shinya、Komatsuzaki Tamiki、Tsuda Masumi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 642 Pages: 41-49
  • DOI: 10.1016/j.bbrc.2022.12.040
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction (2023)
  • Author(s): Tanikawa Satoshi、Ebisu Yuki、Seldacik Tomas、Semba Shingo、Nonoyama Takayuki、Kurokawa Takayuki、Hirota Akira、Takahashi Taiga、Yamaguchi Kazushi、Imajo Masamichi、Kato Hinako、Nishimura Takuya、Tanei Zen-ichi、Tsuda Masumi、Nemoto Tomomi、Gong Jian Ping、Tanaka Shinya
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 2233-2233
  • DOI: 10.1038/s41598-023-28870-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee: Results at three to seven years (2023)
  • Author(s): Kaibara Takuma、Kondo Eiji、Matsuoka Masatake、Iwasaki Koji、Onodera Tomohiro、Sakamoto Keita、Oda Yoshitaka、Tanei Zen-ichi、Momma Daisuke、Tanaka Shinya、Iwasaki Norimasa
  • Journal Title: Journal of Orthopaedic Science Volume: - Issue: 1 Pages: 207-216
  • DOI: 10.1016/j.jos.2022.12.001
  • Peer Reviewed
• [Journal Article] Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats (2023)
  • Author(s): Koizumi Takuya、Watanabe Masaya、Yokota Takashi、Tsuda Masumi、Handa Haruka、Koya Jiro、Nishino Kotaro、Tatsuta Daishiro、Natsui Hiroyuki、Kadosaka Takahide、Koya Taro、Nakao Motoki、Hagiwara Hikaru、Kamada Rui、Temma Taro、Tanaka Shinya、Anzai Toshihisa
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 10 Pages: 1005408-1005408
  • DOI: 10.3389/fcvm.2023.1005408
  • Peer Reviewed / Open Access
• [Journal Article] A case of “genetically defined” radiation‐induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma (2023)
  • Author(s): Masui Kenta、Nitta Masayuki、Muragaki Yoshihiro、Kawamata Takakazu、Satomi Kaishi、Matsushita Yuko、Yoshida Akihiko、Ichimura Koichi、Tsuda Masumi、Tanaka Shinya、Komori Takashi
  • Journal Title: Neuropathology Volume: - Issue: 5 Pages: 425-428
  • DOI: 10.1111/neup.12903
  • Peer Reviewed
• [Journal Article] Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues (2022)
  • Author(s): Tsuda M, Horio R, Wang L, Takenami T, Moriya J, Suzuka J, Sugino H, Tanei Z, Tanino M, Tanaka S.
  • Journal Title: Sci Rep. Volume: 12 Issue: 1 Pages: 1733-1733
  • DOI: 10.1038/s41598-022-05892-7
  • Peer Reviewed / Open Access
• [Journal Article] Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant (2022)
  • Author(s): Suzuki Rigel、Yamasoba Daichi、Kimura Izumi、Wang Lei他
  • Journal Title: Nature Volume: 603 Issue: 7902 Pages: 700-705
  • DOI: 10.1038/s41586-022-04462-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike (2022)
  • Author(s): Yamasoba Daichi、Kimura Izumi、Nasser Hesham他
  • Journal Title: Cell Volume: 未定 Issue: 12 Pages: 2103-2115
  • DOI: 10.1016/j.cell.2022.04.035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of the context of downstream N- and free N-glycomic alterations induced by swainsonine in HepG2 cells (2022)
  • Author(s): Morikawa Chie、Sugiura Kanako、Kondo Keina、Yamamoto Yurie、Kojima Yuma、Ozawa Yurika、Yoshioka Hiroki、Miura Nobuaki、Piao Jinhua、Okada Kazue、Hanamatsu Hisatoshi、Tsuda Masumi、Tanaka Shinya、Furukawa Jun-ichi、Shinohara Yasuro
  • Journal Title: Biochimica et Biophysica Acta (BBA) - General Subjects Volume: 1866 Issue: 9 Pages: 130168-130168
  • DOI: 10.1016/j.bbagen.2022.130168
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5 (2022)
  • Author(s): Kimura et al.
  • Journal Title: Cell Volume: 185 Issue: 21 Pages: 3992-4007
  • DOI: 10.1016/j.cell.2022.09.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant (2022)
  • Author(s): Saito et al.
  • Journal Title: Cell Host & Microbe Volume: 30 Issue: 11 Pages: 1540-1540
  • DOI: 10.1016/j.chom.2022.10.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Force-triggered rapid microstructure growth on hydrogel surface for on-demand functions (2022)
  • Author(s): Mu Qifeng、Cui Kunpeng、Wang Zhi Jian、Matsuda Takahiro、Cui Wei、Kato Hinako、Namiki Shotaro、Yamazaki Tomoko、Frauenlob Martin、Nonoyama Takayuki、Tsuda Masumi、Tanaka Shinya、Nakajima Tasuku、Gong Jian Ping
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 6213-6213
  • DOI: 10.1038/s41467-022-34044-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Machine Learning Algorithms: Prediction and Feature Selection for Clinical Refracture after Surgically Treated Fragility Fracture (2022)
  • Author(s): Shimizu Hirokazu、Enda Ken、Shimizu Tomohiro、Ishida Yusuke、Ishizu Hotaka、Ise Koki、Tanaka Shinya、Iwasaki Norimasa
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 7 Pages: 2021-2021
  • DOI: 10.3390/jcm11072021
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and radiological findings of glioblastomas harboring a BRAF V600E mutation (2022)
  • Author(s): Ishi Yukitomo、Yamaguchi Shigeru、Okamoto Michinari、Sawaya Ryosuke、Endo Shogo、Motegi Hiroaki、Terasaka Shunsuke、Tanei Zen-ichi、Hatanaka Kanako C.、Tanaka Shinya、Fujimura Miki
  • Journal Title: Brain Tumor Pathology Volume: 39 Issue: 3 Pages: 162-170
  • DOI: 10.1007/s10014-022-00432-7
  • Peer Reviewed
• [Journal Article] Neutrophil phenotypes implicated in the pathophysiology of post-traumatic sepsis (2022)
  • Author(s): Mizugaki Asumi、Wada Takeshi、Tsuchida Takumi、Oda Yoshitaka、Kayano Katsuhide、Yamakawa Kazuma、Tanaka Shinya
  • Journal Title: Frontiers in Medicine Volume: 9 Pages: 982399-982399
  • DOI: 10.3389/fmed.2022.982399
  • Peer Reviewed / Open Access
• [Journal Article] Neoatherosclerosis with silent plaque rupture in a saphenous vein graft causing no re-flow phenomenon assessed by optical coherence tomography and histopathology (2022)
  • Author(s): Konishi Takao、Takahashi Yuki、Kazui Sho、Yasui Yutaro、Saiin Kohei、Naito Seiichiro、Takenaka Sakae、Mizuguchi Yoshifumi、Tada Atsushi、Kobayashi Yuta、Omote Kazunori、Sato Takuma、Kamiya Kiwamu、Nagai Toshiyuki、Tanaka Shinya、Anzai Toshihisa
  • Journal Title: Cardiology Journal Volume: 29 Issue: 4 Pages: 718-719
  • DOI: 10.5603/cj.2022.0063
  • Peer Reviewed
• [Journal Article] Vulnerable plaque derived from aspirated thrombi in recurrent acute coronary syndrome with familial hypercholesterolemia despite intensive lipid-lowering statin therapy (2022)
  • Author(s): Natsui Hiroyuki、Konishi Takao、Saiin Kohei、Tamaki Youji、Sato Tomoya、Takenaka Sakae、Tada Atsushi、Mizuguchi Yoshifumi、Kobayashi Yuta、Sato Takuma、Kamada Rui、Kamiya Kiwamu、Nagai Toshiyuki、Tanaka Shinya、Anzai Toshihisa
  • Journal Title: Cardiology Journal Volume: 29 Issue: 2 Pages: 362-363
  • DOI: 10.5603/cj.2022.0018
  • Peer Reviewed
• [Journal Article] Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in adult T-cell leukemia/lymphoma (2022)
  • Author(s): Ishio Takashi、Kumar Sarvesh、Shimono Joji、Daenthanasanmak Anusara、Dubois Sigrid、Lin Yuquan、Bryant Bonita、Petrus Michael N.、Bachy Emmanuel、Huang Da Wei、Yang Yandan、Green Patrick L.、Hasegawa Hiroo、Maeda Michiyuki、Goto Hideki、Endo Tomoyuki、Yokota Takashi、Hatanaka Kanako C.、Hatanaka Yutaka、Tanaka Shinyaら
  • Journal Title: Blood Volume: 139 Issue: 10 Pages: 1541-1556
  • DOI: 10.1182/blood.2021012734
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation (2021)
  • Author(s): Saito Akatsuki、Irie Takashi、Suzuki Rigel、Maemura Tadashi、Nasser Hesham、Uriu Keiya、Kosugi Yusuke、Other 43 authors、Tanaka Shinya、Nakagawa So、Ikeda Terumasa、Fukuhara Takasuke、Kawaoka Yoshihiro、Sato Kei、The Genotype to Phenotype Japan (G2P-Japan) Consortium
  • Journal Title: Nature Volume: 602 Issue: 7896 Pages: 300-306
  • DOI: 10.1038/s41586-021-04266-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels (2021)
  • Author(s): Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S
  • Journal Title: Nat Biomed Eng Volume: － Issue: 8 Pages: 914-925
  • DOI: 10.1038/s41551-021-00692-2
  • Peer Reviewed / Open Access
• [Journal Article] Hydroxyapatite‐hybridized double‐network hydrogel surface enhances differentiation of bone marrow‐derived mesenchymal stem cells to osteogenic cells (2021)
  • Author(s): Kaibara Takuma、Wang Lei、Tsuda Masumi、Nonoyama Takayuki、Kurokawa Takayuki、Iwasaki Norimasa、Gong Jian Ping、Tanaka Shinya、Yasuda Kazunori
  • Journal Title: Journal of Biomedical Materials Research Part A Volume: 110 Issue: 4 Pages: 747-760
  • DOI: 10.1002/jbm.a.37324
  • Peer Reviewed
• [Journal Article] Aberrant expression of MYD88 via RNA‐controlling CNOT4 and EXOSC3 in colonic mucosa impacts generation of colonic cancer (2021)
  • Author(s): Tsuda Masumi、Noguchi Misa、Kurai Tsuyoshi、Ichihashi Yuji、Ise Koki、Wang Lei、Ishida Yusuke、Tanino Mishie、Hirano Satoshi、Asaka Masahiro、Tanaka Shinya
  • Journal Title: Cancer Science Volume: 112 Issue: 12 Pages: 5100-5113
  • DOI: 10.1111/cas.15157
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive molecular profiling of pulmonary pleomorphic carcinoma (2021)
  • Author(s): Nagano Masaaki、Kohsaka Shinji、Hayashi Takuo、Ueno Toshihide、Kojima Shinya、Shinozaki-Ushiku Aya、Morita Shigeki、Tsuda Masumi、Tanaka Shinya、Shinohara Toshiya、Omori Yuko、Sugaya Fumiko、Kato Hiroaki、Narita Yoshiaki、Nakajima Jun、Suzuki Kenji、Takamochi Kazuya、Mano Hiroyuki
  • Journal Title: npj Precision Oncology Volume: 5 Issue: 1 Pages: 57-57
  • DOI: 10.1038/s41698-021-00201-3
  • Peer Reviewed / Open Access
• [Journal Article] The CD44/COL17A1 Pathway Plays a Vital Role in the Formation of Multilayered, Transformed Epithelia. (2021)
  • Author(s): Kozawa K, ,Sekai M, Ohba K, Ito S, Sako H, Maruyama T, Kakeno M , Kuromiya K, Kamasaki T, Kohashi K, Ishikawa S, Sato N, Asano S, Suzuki H, Tanimura N, Mukai Y, Gotoh N, Tanino M, Tanaka S Natsuga K, Soga T. Nakamura T, Yabuta Y, Saitou M, Ito T, Matsuura K, Tsunoda M,et.al..
  • Journal Title: Curr Biol Volume: 31 Issue: 14 Pages: 3086-3097
  • DOI: 10.1016/j.cub.2021.04.078
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure (2021)
  • Author(s): Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S.
  • Journal Title: Commun Biol. Volume: 4 Issue: 1 Pages: 138-138
  • DOI: 10.1038/s42003-021-01675-4
  • Peer Reviewed / Open Access
• [Journal Article] Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression (2021)
  • Author(s): Parajuli Gyanu、Tekguc Murat、Wing James B.、Hashimoto Ari、Okuzaki Daisuke、Hirata Takeshi、Sasaki Atsushi、Itokazu Takahide、Handa Haruka、Sugino Hirokazu、Nishikawa Yoshihiro、Metwally Hozaifa、Kodama Yuzo、Tanaka Shinya、Sabe Hisataka、Yamashita Toshihide、Sakaguchi Shimon、Kishimoto Tadamitsu、Hashimoto Shigeru
  • Journal Title: Cancer Immunology Research Volume: 9 Issue: 8 Pages: 862-876
  • DOI: 10.1158/2326-6066.cir-21-0014
  • Peer Reviewed / Open Access
• [Journal Article] Difference in the malignancy between RAS and GLI1-transformed astrocytes is associated with frequency of p27KIP1?positive cells in xenograft tissues (2021)
  • Author(s): Sasai Ken、Tabu Kouichi、Saito Takashi、Matsuba Yukio、Saido Takaomi C、Tanaka Shinya
  • Journal Title: Pathology - Research and Practice Volume: 223 Pages: 153465-153465
  • DOI: 10.1016/j.prp.2021.153465
  • Peer Reviewed
• [Presentation] Analysis of regulatory mechanism of plasticity towards cancer stemness by hydrogels as biomaterial (2022)
  • Author(s): Shinya Tanaka, Jun Suzuka, Yoshitaka Oda, Yusuke Saitoh, Lei Wang, and Masumi Tsuda
  • Organizer: 第81回日本癌学会学術総会
  • Invited
• [Presentation] Substrate charge regulates stemness of cancer and pluripotent stem cells via metabolic control of pluripotency factors (2022)
  • Author(s): Masamichi Imajo, Akira Hirota, Ryosuke Miyazaki, Jian-Ping Gong, Shinya Tanaka
  • Organizer: The 40th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] Analysis of characteristics of synovial sarcoma stem cells induced by synthetic polymer hydrogels (2022)
  • Author(s): Yuki Terashima, Masumi Tsuda, Kyosuke Fujishima, Kosei Nakamura, Lei Wang, Jian Ping Gong, Shinya Tanaka
  • Organizer: The 40th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] Identification of new targets for pancreatic cancer stem cells using hydrogel and development of therapeutic methods (2022)
  • Author(s): Lei Wang, Yuma Aoki, Masumi Tsuda, Shinya Tanaka
  • Organizer: The 40th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] Differences of the molecular mechanisims in dedifferentiation potential of breast cancer cells using hydrogels (2022)
  • Author(s): Jun Suzuka, Sumito Saeki, Kohei Kumegawa, Yoko Takahashi, Takayuki Ueno, Shinji Ohno, Masumi Tsuda, Shinya Tanaka, Reo Maruyama
  • Organizer: The 40th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] Analysis of cancer stem cells with invasive capacity by Hydrogel-Activated Reprogramming (HARP) phenomenon using PNaSS hydrogel (2022)
  • Author(s): Masumi Tsuda, Jun Suzuka, Yoshitaka Oda, Lei Wang, Yusuke Saito, Jian Ping Gong, Shinya Tanaka
  • Organizer: 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
  • Int'l Joint Research
• [Presentation] Hydrogel PCDME creates pancreatic cancer stem cells in OXPHOS metabolic state with TXNIP elevation (2022)
  • Author(s): Lei Wang, Yuma Aoki, Masumi Tsuda, Yusuke Saito, Takenori Kubota, Yoshitaka Oda, Satoshi Hirano, Jian Ping Gong, Shinya Tanaka
  • Organizer: 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
  • Int'l Joint Research
• [Presentation] Analysis of pathological and biological roles for chemokine receptor CXCR4 identified via reprogramming by hydrogel in meningioma stem cells (2022)
  • Author(s): Yoshitaka Oda, Masumi Tsuda, Sayaka Yuzawa, Lei Wang, Satoshi Tanikawa, Zen-ichi Tanei, Christian Mawrin, Jian Ping Gong, Shinya Tanaka
  • Organizer: 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research: Translating Knowledge into Practice
  • Int'l Joint Research
• [Presentation] 細胞外基質の電位変化に伴うJCウイルス増殖の制御 (2022)
  • Author(s): 谷川聖、野々山貴行、津田真寿美、王磊、種井善一、Gong Jian Ping、田中伸哉
  • Organizer: 第111回日本病理学会総会
• [Presentation] 脊髄 capillary hemangioma の臨床病理学的特徴 (2022)
  • Author(s): 種井 善一，津田 真寿美，小田 義崇，谷川 聖，杉野 弘和，大竹 安史，今村 博幸，小柳 泉，飛騨 一利，田中伸哉
  • Organizer: 第111回日本病理学会総会
• [Presentation] 肺癌における新規作用機序チロシンキナーゼ阻害剤の解析 (2022)
  • Author(s): 津田真寿美、王磊、田中伸哉
  • Organizer: 第26回日本がん分子標的治療学会学術集会
• [Presentation] ハイドロゲルを用いた膵癌幹細胞の新規ターゲットの同定及び治療法の開発 (2022)
  • Author(s): 王 磊、青木 佑磨、津田 真寿美、田中伸哉
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] ハイドロゲルを用いた髄膜腫がん幹細胞マーカーの検索 (2022)
  • Author(s): 小田 義崇、津田 真寿美、湯澤 明夏、王 磊、谷川 聖、種井善一、グン 剣萍、田中伸哉
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] Analysis of cancer stem cells at invasive front niche (2022)
  • Author(s): Masumi Tsuda, Shinya Tanaka
  • Organizer: 第81回日本癌学会学術総会
  • Invited
• [Presentation] SARS-CoV-2変異株を用いたハムスター肺炎モデルの病理組織学的解析 (2022)
  • Author(s): 小田義崇、津田真寿美、王磊、谷川聖、種井善一、G2P-Japan、福原崇介、佐藤佳、 田中伸哉
  • Organizer: 第68回日本病理学会秋期特別総会
• [Presentation] 新規がん微小環境によるがん幹細胞の創出. DNゲルはオステオポンチンを介してがん細胞のリプログラミングを誘導する (2021)
  • Author(s): 田中伸哉
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] ハイドロゲルを用いた悪性中皮腫細胞の幹細胞性誘導 (2021)
  • Author(s): 杉野弘和、王磊、津田真寿美、鈴鹿淳、谷野美智枝、グン剣萍、田中伸哉
  • Organizer: 第110回日本病理学会総会
• [Presentation] ハイドロゲルによる癌幹細胞性の誘導を利用した髄膜腫の新規治療標的分子の検索 (2021)
  • Author(s): 小田義崇、津田真寿美、湯澤明夏、王磊、杉野弘和、鈴鹿淳、グン剣萍、田中伸哉
  • Organizer: 第110回日本病理学会総会
• [Presentation] 高分子ハイドロゲルによるリプログラミングを利用した癌幹細胞標的治療薬の同定 (2021)
  • Author(s): 津田真寿美、鈴鹿淳、王磊、田中伸哉
  • Organizer: 第25回日本がん分子標的治療学会学術集会
• [Presentation] Effect of scaffold stiffness on hydrogel-induced cancer stemness of cancer model cells (2021)
  • Author(s): Yanpeng Sun, Masumi Tsuda, Lei Wang, Hirokazu Sugino, Jian Ping Gong, Shinya Tanaka
  • Organizer: The 39th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] Analysis of epigenetic characteristics of sarcoma stem cells induced by multifunctional hydrogels (2021)
  • Author(s): Yuheng Nie, Masumi Tsuda, Lei Wang, Jian Ping Gong, Shinya Tanaka
  • Organizer: The 39th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] 新規ハイドロゲルXはエピジェネティックな調節に関与しがん幹細胞性を誘導する (2021)
  • Author(s): 鈴鹿 淳、津田 真寿美、王 磊、粂川 昂平、丸山 玲緒、田中 伸哉
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 合成高分子ハイドロゲルを用いた滑膜肉腫幹細胞の細胞周期及びEMT/MET解析 (2021)
  • Author(s): 寺島祐樹、津田真寿美、藤島京祐、中村恒星、王磊、グン剣萍、田中伸哉
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] 高分子ハイドロゲルを用いた神経膠芽腫幹細胞の誘導メカニズムの解明 (2021)
  • Author(s): 藤島京祐、津田真寿美、王磊、グン剣萍、田中伸哉
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] ハイドロゲルを用いたグリオブラストーマにおける幹細胞マーカー発現制御シグナル経路の解析 (2021)
  • Author(s): 中村恒星、津田真寿美、寺島祐樹、藤島京祐、王磊、グン剣萍、田中伸哉
  • Organizer: 第44回日本分子生物学会年会
• [Presentation] 基質電荷による多能性幹細胞の中胚葉分化制御機構の解析 (2021)
  • Author(s): 山川大輔、今城正道、廣田聡、田中伸哉
  • Organizer: 第44回日本分子生物学会年会
• [Book] がんゲノム病理学 (2021)
  • Author(s): 田中伸哉、西原広史
  • Total Pages: 234
  • Publisher: 文光堂
• [Remarks]
  • URL: http://patho2.med.hokudai.ac.jp
• [Patent(Industrial Property Rights)] 細胞培養器、細胞培養キット、および細胞培養方法 (2021)
  • Inventor(s): 黒川孝幸、勝山吉徳、グン剣萍、田中伸哉、津田真寿美
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2021-151208
  • Filing Date: 2021