| Co-Investigator(Renkei-kenkyūsha) |
KOSHIKAWA Naohiko 東京大学, 医科学研究所, 准教授 (70334282)
SAKAMOTO Takeharu 東京大学, 医科学研究所, 助教 (70511418)
HOSHINO Daisuke 東京大学, 医科学研究所, 助教 (30571434)
SYUUO Takuya 東京大学, 医科学研究所, 特任研究員 (90399006)
NAGANO Makoto 摂南大学, 薬学部, 助教 (50572715)
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| Budget Amount *help |
¥214,240,000 (Direct Cost: ¥164,800,000、Indirect Cost: ¥49,440,000)
Fiscal Year 2013: ¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2012: ¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2011: ¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2010: ¥66,820,000 (Direct Cost: ¥51,400,000、Indirect Cost: ¥15,420,000)
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| Research Abstract |
Cancer cells are usually destructive against surrounding tissue and this activity is necessary for the cells to continue grow abnormally, invade and form metastatic tumor nodules. Cancer cells also alter the tumor microenvironment by producing different tissue constituents from the normal ones and by changing the integrity of extracellular proteins via protein processing. Degradation and processing of proteins in the tissue space are mediated by extracellular proteases. Membrane type 1 matrix metalloproteinase (MT1-MMP) is one of such extracellular proteases expressed in cancer cells. In this study, we analyzed multidimensional functions of MT1-MMP and their coordinated action with intracellular systems regulating cell growth and invasion. The results suggest that MT1-MMP is important acting as a nordal point regulator during acquisition of malignant phenotype of cancer cells.
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