Integrative approaches toward the development of next-generation therapeutics for myocardial infarction

• Project/Area Number: 22229007
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Advanced Telecommunications Research Institute International (2014-2015); Nara Institute of Science and Technology (2010-2013)
• Principal Investigator: Thomas N. Sato 株式会社国際電気通信基礎技術研究所, 佐藤匠徳特別研究所, 所長 (60548759)
• Co-Investigator(Kenkyū-buntansha): AKANUMA Takashi 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教 (50450721)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥165,620,000 (Direct Cost: ¥127,400,000、Indirect Cost: ¥38,220,000); Fiscal Year 2014: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000); Fiscal Year 2013: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000); Fiscal Year 2012: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000); Fiscal Year 2011: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000); Fiscal Year 2010: ¥71,240,000 (Direct Cost: ¥54,800,000、Indirect Cost: ¥16,440,000)
• Keywords: 分子心臓病態学 / 心筋梗塞 / 線維化 / 線維芽細胞 / 血管形成 / 細胞内代謝 / 細胞老化 / sFRP2 / Pcolce-1 / 血管内皮細胞 / 組織再生

Outline of Final Research Achievements

1.Identification of a family of angiocrine factors that are essential for organ regeneration. 2.Identification of a new class of inter-organ vascular network.
3.Identification of a drug that inhibits fibroblast-specific intracellular metabolism. We show that inhibition of fibrosis combined with increased cardiac angiogenesis caused by this drug improve cardiac function in myocardial infarction. 4.Identification of a new role of neurons in angiogenesis. 5.Identification of a family of cardiac factors that play critical roles in dysfunction of non-cardiac organs/tissues in cardiac diseases.

Assessment Rating

Verification Result (Rating)

B

Research Products

• [Journal Article] Memory of cell shape biases stochastic fate decision-making despite mitotic rounding (2016)
  • Author(s): Akanuma, T., Chen, C., Sato, T., Merks, R.M.H., Sato, T.N.
  • Journal Title: Nature Communications Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Whole-mount single molecule FISH method for zebrafish embryo (2015)
  • Author(s): Yuma Oka, Thomas N. Sato
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 8571-8571
  • DOI: 10.1038/srep08571
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neurons limit angiogenesis by titrating VEGF in retina. (2014)
  • Author(s): Okabe K, Kobayashi S, Yamada T, Kurihara T, Tai-Nagara I, Miyamoto T, Mukouyama YS, Sato TN, Suda T, Ema M, Kubota Y
  • Journal Title: Cell Volume: 159 Issue: 3 Pages: 584-596
  • DOI: 10.1016/j.cell.2014.09.025
  • Peer Reviewed / Open Access
• [Journal Article] An Anthelmintic Drug, Pryvinium Pamoate, Thwarts Fibrosis and Ameliorates Myocardial Contractile Dysfunction in a Mouse Model of Myocardial Infarction (2013)
  • Author(s): Murakoshi, M, et.al.
  • Journal Title: PLOS ONE Volume: 8 Issue: 11 Pages: e79374-e79374
  • DOI: 10.1371/journal.pone.0079374
  • Peer Reviewed
• [Journal Article] Identification of Inter-Organ Vascular Network: Vessels Bridging between Organs (2013)
  • Author(s): Omae, M, et. al.
  • Journal Title: PLOS ONE Volume: 8 Issue: 6 Pages: e65720-e65720
  • DOI: 10.1371/journal.pone.0065720
  • Peer Reviewed
• [Journal Article] KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development (2013)
  • Author(s): Orit Goldman, et.al.
  • Journal Title: Cell stem Cell Volume: 12 Issue: 6 Pages: 748-760
  • DOI: 10.1016/j.stem.2013.04.026
  • Peer Reviewed
• [Journal Article] Synthetic cell division system: Controlling equal vs. unequal divisions by design (2013)
  • Author(s): Yoichi Sato, et. al.
  • Journal Title: Scientific Reports Volume: 3 Issue: 1 Pages: 3475-3475
  • DOI: 10.1038/srep03475
  • Peer Reviewed
• [Journal Article] Identification of inter-organ vascular network: Vessels bridging between organs. (2013)
  • Author(s): Omae, M, et. al.
  • Journal Title: PLOS ONE Volume: In Press
  • Peer Reviewed
• [Journal Article] Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization (2011)
  • Author(s): Ding BS, et.al.
  • Journal Title: Cell Volume: 147 Issue: 3 Pages: 539-553
  • DOI: 10.1016/j.cell.2011.10.003
  • Peer Reviewed
• [Journal Article] Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration (2010)
  • Author(s): Ding BS, et.al.
  • Journal Title: Nature Volume: 468 Pages: 310-315
  • Peer Reviewed
• [Presentation] "Controlling fibrosis by design via targeting intracellular metabolism" (2015)
  • Author(s): 佐藤匠徳
  • Organizer: 第2回日本腎臓研究会(2nd Japan Kidney Conference)
  • Place of Presentation: 経団連会館２F国際会議場
  • Year and Date: 2015-01-17
• [Presentation] 「細胞内代謝デザインによる疾患治療」、「研究者という人生を選択することで得るもの失うもの」 (2014)
  • Author(s): 佐藤匠徳
  • Organizer: 第13回CRC (Cardiovascular Research Conference
  • Place of Presentation: 山の上ホテル（東京）
  • Year and Date: 2014-11-12
• [Presentation] Beyond “What is Life? (1994)” (2014)
  • Author(s): 佐藤匠徳
  • Organizer: サマースクール/岡崎統合バイオサイエンスセンター総合研究大学院大学「統合生命科学教育プログラム」
  • Place of Presentation: 岡崎統合バイオサイエンスセンター総合研究大学院大学
  • Year and Date: 2014-08-27
  • Invited
• [Presentation] Herat Repair With and Without Blood Vessels (2014)
  • Author(s): 佐藤 匠徳
  • Organizer: 第10回宮崎サイエンスキャンプ
  • Place of Presentation: シーガイアコンベンションセンター
  • Invited
• [Presentation] 細胞内代謝調節機構を自在に操ることで細胞の生死を操作する：ヒト疾患治療への応用を目指して (2014)
  • Author(s): 佐藤 匠徳
  • Organizer: 第７回The Heart 研究会
  • Place of Presentation: 東京国際フォーラムホール D5
• [Presentation] Heart Repair with and without Blood Vessel (2013)
  • Author(s): 佐藤 匠徳
  • Organizer: Cornell University, Department of Biomedical Engineering
  • Place of Presentation: Cornell University, Department of Biomedical Engineering
• [Presentation] 細胞内代謝調節を自在に操ることで細胞の生死をデザインする：ヒト疾患治療への応用を目指して (2013)
  • Author(s): 佐藤 匠徳
  • Organizer: 第17回西スクリプス・バイメディカルフォーラム
  • Place of Presentation: 新大阪ワシントンホテルプラザ
• [Presentation] 特別講演I Starving cardiac fibroblast to death by sedating mitochondrial energy metabolism (2013)
  • Author(s): 佐藤 匠徳
  • Organizer: 成人病の原因・病態の解明に関する研究助成 第19回研究発表会（TMFC）
  • Place of Presentation: セントレジスホテリ大阪 １１階アスターボールルーム
• [Book] “Mechanical and chemical regulation of arterial and venous specification” In: Mechanical and Chemical Signaling in Angiogenesis. (2013)
  • Author(s): Sato, TN
  • Publisher: Springer Verlag
• [Book] 「Annual Review 循環器2012」II-4.心筋梗塞における線維化の制御機構 (2012)
  • Author(s): 山田親臣、佐藤匠徳
  • Publisher: 中外医学社
• [Remarks] 読売新聞平成22年11月11日研究論文(Nature誌)記事
  • URL: http://bsw3.naist.jp/tns/images/contents/160/20101111Yomiuri-article.pdf
• [Patent(Industrial Property Rights)] 虚血性疾患の治療又は予防のための薬剤及びその利用 (2013)
  • Inventor(s): 佐藤匠徳、村越幹昭
  • Industrial Property Rights Holder: 奈良先端科学技術大学院大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-02-15