Development of higher cognitive functions based on the subcortical brain areas
Project/Area Number |
22240051
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Fusional social brain science
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Research Institution | University of Toyama |
Principal Investigator |
NISHIJO Hisao 富山大学, 大学院・医学薬学研究部(医学), 教授 (00189284)
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Co-Investigator(Kenkyū-buntansha) |
HORI Etsuro 富山大学, 大学院・医学薬学研究部(医学), 准教授 (90313600)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2010: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
|
Keywords | 上丘 / 視床枕 / 扁桃体 / 社会行動 / 脳発達 / 自閉症 / 情動 / 社会的認知機能 / アイコンタクト |
Research Abstract |
This study investigated a role the extrageniculate visual system (subcortical system) consisting of retina → superior colliculus (SC) → pulvinar → amygdala in the brain development. The neurophysiological results indicated that neurons in these areas responded to social stimuli including faces and eye contact with short response latencies. The lesion of the SC induced autistic-likedeficits in monkeys. Furthermore, neuroanatomical studies using various kinds of animal models of autisms indicated that the number of parvalbumin-positive (GABAergic) neurons was decreased in these areas.
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Report
(4 results)
Research Products
(133 results)
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[Journal Article] Influence of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on socioemotional behaviors in offspring rats.2013
Author(s)
Nguyen AT, Nishijo M, Hori E, Nguyen NM, Pham TT, Fukunaga K, Nakagawa H, Tran AH, Nishijo H.
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Journal Title
Environ Health Insights
Volume: 7
Pages: 1-14
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of perinatal dioxin exposure on infant growth: a cross-sectional and longitudinal studies in dioxin- contaminated areas in Vietnam.2012
Author(s)
Nishijo M, Tai PT, Nakagawa H, Maruzeni S, Anh NTN, Luong HV, Anh TH, Honda R, Morikawa Y, Kido T, Nishijo H
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Journal Title
PLoS ONE
Volume: 7(7)
Issue: 7
Pages: e40273-e40273
DOI
Related Report
Peer Reviewed
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[Journal Article] Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site specific binding2012
Author(s)
Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki JI, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M
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Journal Title
J Biol Cbem
Volume: (印刷中)
Issue: 18
Pages: 14631-14643
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of dioxins exposure on social emotional behavior of children living in a hot spot area, Vietnam.2012
Author(s)
Nishijo M, Tai PT, Nui NM, Anh NTN, Hai NM, Maruzeni S, Nghi T.N., Phuong P.T., Nishijo H, Anh TH, Luong HV, Kido T, Okamoto R, Son LK, Nakagawa H.
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Journal Title
Organohalogen Compounds
Volume: 74
Pages: 1332-1335
Related Report
Peer Reviewed
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[Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.2011
Author(s)
Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
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Journal Title
Hippocampus
Volume: 21
Pages: 678-687
Related Report
Peer Reviewed
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[Journal Article] Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice.2011
Author(s)
Nguyen PTH, Nakamura T, Hori E, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice2011
Author(s)
Nguyen PTH, Nakamura T, Hori E, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Dioxin concentrations in breast milk of Vietnamese nursing mothers ; A survey after four decades from the end of spraying herbicides2011
Author(s)
Pham-The T, Nishijo M, Kido T, Nakagawa N, Maruzeni S, Nguyen-Thi NA, Morikawa Y, Hoang V L, Tran HA, Nguyen NH, Le-Ke S, Nishijo H
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Journal Title
Environ Sci Tech
Volume: 45(15)
Pages: 6625-6632
Related Report
Peer Reviewed
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[Journal Article] The inositol phosphatase SHIP2 negatively regulates insulin/IGF-1 actions implicated in neuroprotection and memory function in mouse brain.2010
Author(s)
Soeda Y, Tsuneki H, Muranaka H, Mori N, Hosoh S, Ichihara Y, Kagawa S, Wang X, Toyooka N, Takamura Y, Uwano T, Nishijo H, Wada T, Sasaoka T.
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Journal Title
Mol.Endocrinol
Volume: 24
Pages: 1965-1977
Related Report
Peer Reviewed
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[Journal Article] Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-ss gene knockout mice.2010
Author(s)
Nguyen PTH, Nakamura T, Hori E, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.2010
Author(s)
Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
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Journal Title
Related Report
Peer Reviewed
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[Presentation] Effecte of dioxins exposure on social emotional behavior of children living in a hot spot area, Vietnam.2012
Author(s)
Nshijo M, Tai PT, Nui NM, Anh NTN, Hai NM, Maruzeni S, Nghi TN, Phuong PT, Nishijo H, Anh TH, Luong HV, Kido T, Okamoto R, Son LK, Nakagawa H.
Organizer
Dioxin 2012
Place of Presentation
Cairns, Australia
Related Report
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[Presentation] Dioxin exposure and infant neurodevelopment – a follow up study in Vietnamese infants. 32nd International Symposium on Halogenated Persistent Organic Pollutants.2012
Author(s)
Tai PT, Nishijo M, Nakagawa H, Maruzeni S, Anh NTN, Luong HV, Anh TH, Morikawa Y, Kido T, Nishijo H.
Organizer
Dioxin 2012
Place of Presentation
Cairns, Australia
Related Report
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[Presentation] T-817MA, a novel neurotophic agent ameliorate behavior and gamma oscillation of PDGFR-β KO mice that displayed schizophrenia- and autism-like symptoms.2012
Author(s)
Nakamura T, Phuong THN, Hori E, Urakawa S, Uwano T, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H.
Organizer
35th Japan Neuroscience Meeting
Place of Presentation
Nagoya
Related Report
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[Presentation] Effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on socio-emotional behaviour in offspring rats.2012
Author(s)
Nguyen TNA, Nishijo M, Hori E, Nguyen NM, Pham TT, Nakagawa H, Tran HA, Nguyen DB, Nishijo H.
Organizer
Vietnamse Physiological Meeting
Place of Presentation
Hue, Viet Nam
Related Report
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[Presentation] Effects of dioxin exposure in breast milk of nursing mothers on neurodevelopment of infants in Vietnam.2012
Author(s)
Pham TT, Nishijo M, Nakagawa H, Maruzeni S, Nguyen TNA, Hoang VL, Tran HA, Nguyen DB, Morikawa Y, Kido T, Nishijo H.
Organizer
Vietnamse Physiological Meeting
Place of Presentation
Hue, Viet Nam
Related Report
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[Presentation] 血小板由来成長因子β受容体遺伝子ノックアウトマウスは統合失調症陰性症状および自閉症様症状を呈する.2012
Author(s)
中村友也, Phuong THN, 堀 悦郎, 浦川 将, 上野照子, 濱島 丈, 石井陽子, 松島貴子, 小野武年, 笹原正清, 西条寿夫
Organizer
第二回日本情動学会
Place of Presentation
東京
Related Report
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[Presentation] 新規栄養因子様化合物T-817MA は統合失調症および自閉症様症状を呈する PDGFR-βKO マウスの症状を改善する.2012
Author(s)
中村友也, Phuong THN, 堀 悦郎, 浦川 将, 上野照子, 濱島 丈, 石井陽子, 松島貴子, 小野武年, 笹原正清, 西条寿夫
Organizer
第二回日本情動学会
Place of Presentation
東京
Related Report
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[Presentation] Schizophrenia and autism-like symptom in Platelet-Derived Growth Factor Receptor-β Gene Knockout mice.2011
Author(s)
Nakamura T, Phuong THN, Hori E, Urakawa S, Wano T, Juanjuan Z, Ruixi L, Nguyen DB, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, and Nishijo H.
Organizer
The 6th International Conference of Neurons and Brain Diseases
Place of Presentation
Toyama.
Year and Date
2011-08-05
Related Report
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[Presentation] Schizophrenia and autism-like symptom in Platelet-Derived Growth Factor Receptor-β Gene Knockout mice2011
Author(s)
Nakamura T., Phuong T.H.N., Hori E., Urakawa S., Wano T., Juanjuan Z., Ruixi L., Nguyen D.B., Hamashima T., Ishii Y., Matsushima T., Ono T., Sasahara M., Nishijo H.
Organizer
The 6th International Conference of Neurons and Brain Diseases
Place of Presentation
Toyama
Year and Date
2011-08-05
Related Report
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[Presentation] Effects of Dioxins Exposure on infant growth in a hot spot area, Vietnam2011
Author(s)
Nishijo M., Pham T.T., Nguyen T.N., Maruzen S., Nishijo H., Tran H.A., Hoang V.L., Kido T., Naganuma R., Ngyen M.H., Le K.S.
Organizer
31th International Symposium on Halogenated persistent Organic Pollutants ; Dioxin 2011
Place of Presentation
Brussels
Related Report
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[Presentation] マウスにおける血管由来成長因子受容体β遺伝子欠損は認知および社会行動障害を誘導する2011
Author(s)
中村友也, Phuong Thi Hong Nguyen, 堀悦郎, 浦川将, 上野照子, Juanjuan Zhao, Ruixi Li, Nguyen Duy Bac, 濱島丈, 石井陽子, 小野武年, 笹原正清, 西条寿夫
Organizer
第34回日本神経科学大会
Place of Presentation
東京
Related Report
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[Presentation] 血小板由来成長因子β受容体遺伝子ノックアウトマウスにおけるガンマオシレーションの障害2011
Author(s)
中村友也, Phuong T.H.N, 堀悦郎, 浦川将, 上野照子, Juanjuan Z, Ruixi L, Nguyen D.B, 濱島丈, 石井陽子, 松島貴子, 小野武年, 笹原正清, 西条寿夫
Organizer
第58回中部日本生理学会
Place of Presentation
福井
Related Report
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[Presentation] Conditional depletion of PDGF-ss receptor gene in the central nervous system induced deficits in higher brain functions in mice.2010
Author(s)
Nguyen T.H.P., Hori E., Zhao J., Ruixi L., Urakawa S., Uwano T., Hamashima T., Ishii Y., Matsushima T., Sasahara M., Ono T., Nishijo H.
Organizer
第57回中部日本生理学会
Place of Presentation
名古屋
Year and Date
2010-10-15
Related Report
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[Presentation] 瞳孔反応と情動.2010
Author(s)
堀悦郎, 小野武年, 西条寿夫
Organizer
電子情報通信学会イメージクオリティ研究会基調講演
Place of Presentation
富山
Year and Date
2010-08-27
Related Report
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[Presentation] 幼若サルの社会行動における上丘の役割.2010
Author(s)
堀悦郎, R S.Maior, M C.Tavares, Tomaz C., 小野武年, 西条寿夫
Organizer
包括型脳科学研究推進支援ネットワーク夏のワークショップ
Place of Presentation
札幌
Year and Date
2010-07-27
Related Report
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[Presentation] 各被験者に特異的な事象に関する問題解答時の前頭前野脳血行動態:近赤外分光法を用いた解析.2010
Author(s)
浦川将, 森山美里, 岩崎靖子, 高本考一, 堀悦郎, 石川亮宏, 塩見真一, 河野理, 安本吏恵, 小野武年, 西条寿夫
Organizer
第12回日本ヒト脳機能マッピング学会
Place of Presentation
東京
Related Report
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[Book] Organohalogen Compounds2012
Author(s)
Nishijo M, Tai PT, Nui NM, Anh NTN, Hai NM, Maruzeni S, Nghi TN, Phuong PT, Nishijo H, Anh TH, Luong HV, Kido T, Okamoto R, Son LK, Nakagawa H
Publisher
Effects of dioxins exposure on social emotional behavior of children living in a hot spot area, Vietnam.
Related Report
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