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Generation of non-human primate disease model by loss-of-gene function

Research Project

Project/Area Number 22240053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionCentral Institute for Experimental Animals

Principal Investigator

sasaki erika  公益財団法人実験動物中央研究所, その他部局等, その他 (70390739)

Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2010: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Keywordsノックダウン / II型糖尿病 / インスリンレセプター / マーモセット / 実験動物学 / 発生工学 / 疾患モデル / 糖尿病 / 実験動物 / 遺伝子 / RNAi
Outline of Final Research Achievements

The common marmoset (Callithrix jacchus) is the only primate that has been used to generate transgenic animals with germline transmission of the transgene to their offspring. However, transgenic non-human primates that show loss-of-gene function are required to create various disease models. In this study, we tried generation of loss-of-gene function transgenic marmoset disease models.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (64 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (46 results) (of which Invited: 26 results) Book (6 results)

  • [Journal Article] Birth of Healthy Offspring Following ICSI in In Vitro-Matured Common Marmoset (Callithrix jacchus) Oocytes2014

    • Author(s)
      Tsukasa Takahashi, Kisaburo Hanazawa, Takashi Inoue, Kenya Sato, Ayako Sedohara, Junko Okahara, Hiroshi Suemizu, Chie Yagihashi, Masafumi Yamamoto, Yusuke Konno, Hideyuki Okano, Makoto Suematsu, Erika Sasaki
    • Journal Title

      PLOS ONE

      Volume: 9(4) Issue: 4 Pages: e95560-e95560

    • DOI

      10.1371/journal.pone.0095560

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Common marmoset as a new model animal for neuroscience research and genome editing technology.2014

    • Author(s)
      Kishi N, Sato K, Sasaki E, Okano H.
    • Journal Title

      Dev Growth Differ.

      Volume: 56(1) Issue: 1 Pages: 53-62

    • DOI

      10.1111/dgd.12109

    • NAID

      40019949271

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi dimensional MRI-CT atlas of the naked mole-rat brain (Heterocephalus glaber)2013

    • Author(s)
      Seki F, Hikishima K, Nambu S, Okanoya K, Okano HJ, Sasaki E, Miura K (corresponding author) and H. Okano.
    • Journal Title

      Frontiers in Neuroanatomy

      Volume: 7 Issue: DEC Pages: 1-12

    • DOI

      10.3389/fnana.2013.00045

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes.2013

    • Author(s)
      Suemizu H, Kawai K, Higuchi Y, Hashimoto H, Ogura T, Itoh T, Sasaki E, Nakamura M.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 12 Pages: e82708-e82708

    • DOI

      10.1371/journal.pone.0082708

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minimally invasive transabdominal collection of preimplantation embryos from the common marmoset monkey (Callithrix jacchus)2012

    • Author(s)
      Hanazawa, K.
    • Journal Title

      Theriogenology

      Volume: 78(4) Issue: 4 Pages: 811-816

    • DOI

      10.1016/j.theriogenology.2012.03.029

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Derivation of induced pluripotent stem cells by retroviral gene transduction in Mammalian species2012

    • Author(s)
      Imamura, M.
    • Journal Title

      Methods Mol Biol

      Volume: 925 Pages: 21-48

    • DOI

      10.1007/978-1-62703-011-3_2

    • ISBN
      9781627030106, 9781627030113
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular signatures to define spermatogenic cells in common marmoset (Callithrix jacchus)2012

    • Author(s)
      Lin, ZY
    • Journal Title

      Reproduction

      Volume: 143 Pages: 597-609

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile 122 allele : A valid pathological model of the human disease2012

    • Author(s)
      Ueda M
    • Journal Title

      Lab Invest

      Volume: 92 Issue: 3 Pages: 474-84

    • DOI

      10.1038/labinvest.2011.195

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus2012

    • Author(s)
      Kelava l
    • Journal Title

      Cereb Cortex

      Volume: 22 Pages: 469-481

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in cortical interneuron migration contribute to the evolution of the neocortex2011

    • Author(s)
      Tanaka DH
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Pages: 8015-8020

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene targeting and subsequent site-specific transgenesis at the β-actin (ACTB) locus in common marmoset embryonic stem cells2011

    • Author(s)
      Shiozawa S
    • Journal Title

      Stem Cells Dev

      Volume: 108 Pages: 1587-1599

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minimally invasive transabdominal collection of preimplantation embryos from the common marmoset monkey (Callithrix jacchus)

    • Author(s)
      Hanazawa, K
    • Journal Title

      Theriogenology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 次世代実験動物としてのコモンマーモセットの開発2014

    • Author(s)
      佐々木えりか
    • Organizer
      第87回日本生化学大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Possibility of genetically nonhuman primate models in biomedical research2014

    • Author(s)
      佐々木えりか
    • Organizer
      Asian Retina Meeting2014
    • Place of Presentation
      東北大学
    • Year and Date
      2014-09-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 疾患マーモセットモデルを作る2014

    • Author(s)
      佐々木えりか
    • Organizer
      第37回日本脳神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 次世代発生工学研究のモデル動物、コモンマーモセット2014

    • Author(s)
      佐々木えりか
    • Organizer
      京都大学霊長類研究所研究会、霊長類への展開に向けた幹細胞・生殖細胞・エピゲノム研究会
    • Place of Presentation
      京都大学霊長類研究所
    • Year and Date
      2014-08-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 次世代実験動物としての遺伝子改変マーモセット2014

    • Author(s)
      佐々木えりか
    • Organizer
      第44回(2014)新潟神経学夏期セミナー
    • Place of Presentation
      新潟大学脳研究所 統合脳機能研究センター(6F)セミナーホール
    • Year and Date
      2014-08-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Non-human primate models in biomedical research2014

    • Author(s)
      佐々木えりか
    • Organizer
      熊本大学発生医学研究所リエゾンラボセミナー
    • Place of Presentation
      熊本大学
    • Year and Date
      2014-07-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] インスリンレセプター遺伝子ノックダウンによるII型糖尿病モデルマーモセット作出の試み2014

    • Author(s)
      高橋 司、前田 拓志、久下 壮、 佐藤 賢哉、伊藤 亮治、佐々木 えりか
    • Organizer
      実験動物科学技術 さっぽろ 2014
    • Place of Presentation
      北海道、札幌コンベンションセンター
    • Year and Date
      2014-05-15 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] コモンマーモセットにおける受精卵凍結法の検討2013

    • Author(s)
      岡原純子、山田祐子、江藤智生、山崎未来、石割桂、澤田賀久、佐々木えりか
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      福岡県、九州大学百年講堂
    • Year and Date
      2013-12-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロチップを用いた個体情報管理システムの構築について2013

    • Author(s)
      岡原則夫、井上貴史、佐々木えりか、伊藤豊志雄
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      福岡県、九州大学百年講堂
    • Year and Date
      2013-12-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 標的遺伝子ノックダウンによるII型糖尿病モデルマーモセット作出の試み2013

    • Author(s)
      高橋司、前田拓志、久下壮、佐藤賢哉、井上慎一、伊藤亮二、佐々木えりか
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      福岡県、九州大学百年講堂
    • Year and Date
      2013-12-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癲癇発作後に行動異常を呈したコモンマーモセットの脳萎縮症例2013

    • Author(s)
      山崎未来、井上貴史、疋島啓吾、保田昌彦、川井健司、石割桂、澤田賀久、岡原純子、岡野栄之、佐々木えりか、伊藤豊志雄
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      福岡県、九州大学百年講堂
    • Year and Date
      2013-12-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] エピゾーマルベクターを用いたコモンマーモセット体細胞の再プログラム化2013

    • Author(s)
      Shin-ichi Inoue, Hiroshi Igarashi, Hideyuki Okano, Erika Sasaki
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      福岡県、九州大学百年講堂
    • Year and Date
      2013-12-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] Generation of transgenic common marmosets carrying a pluripotency reporter construct2013

    • Author(s)
      Tobias Kahland, Junko Okahara, Akitsu Hotta, Rudiger Behr, James Ellis, Erika Sasaki
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      福岡県、九州大学百年講堂
    • Year and Date
      2013-12-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 次世代実験動物としての遺伝子改変マーモセット2013

    • Author(s)
      佐々木えりか
    • Organizer
      第3回日本マーモセット研究会大会
    • Place of Presentation
      福岡県、九州大学百年講堂
    • Year and Date
      2013-12-12
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次世代動物としての遺伝子改変マーモセット2013

    • Author(s)
      佐々木えりか
    • Organizer
      成体脳ニューロン新生懇談会
    • Place of Presentation
      東京都、東京慈恵会医科大学
    • Year and Date
      2013-11-30
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Establishment of non human primate preclinical study system for regenerative medicine2013

    • Author(s)
      Erika Sasaki
    • Organizer
      2nd Osong LAC International Symposium & Osong Lac-CIEA Joint Symposium
    • Place of Presentation
      Osong, Korea
    • Year and Date
      2013-11-26
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] コモンマーモセットを用いた疾患モデル作出法の開発2013

    • Author(s)
      佐々木えりか
    • Organizer
      第58回日本人類遺伝学会
    • Place of Presentation
      宮城県、江陽グランドホテル
    • Year and Date
      2013-11-20
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 霊長類コモンマーモセットの遺伝子改変技術の開発2013

    • Author(s)
      佐々木えりか
    • Organizer
      第63回幹細胞治療研究フォーラム
    • Place of Presentation
      東京都、東京大学医科学研究所
    • Year and Date
      2013-10-18
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Transgenic marmoset for human disease models2013

    • Author(s)
      佐々木えりか
    • Organizer
      第6回都医学研国際シンポジウムMarmoset Neuroscience - Anatomy, Development and Function
    • Place of Presentation
      東京都、東京都医学総合研究所
    • Year and Date
      2013-10-03
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genetically modified non-human primate models2013

    • Author(s)
      Erika Sasaki
    • Organizer
      Behavior & Neurogenetics of Nonhuman Primates
    • Place of Presentation
      Cold Spring Harbor, U.S.A
    • Year and Date
      2013-09-06
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genetically modified non-human primate as human disease models2013

    • Author(s)
      Erika Sasaki
    • Organizer
      KALAS International Symposium
    • Place of Presentation
      ICC JEJU, Korea
    • Year and Date
      2013-08-22
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Pattern of early gene expression during early marmoset development2013

    • Author(s)
      Ayako Sedohara, Hideyuki Okano, Erika Sasaki
    • Organizer
      The 46th Annual Meeting for the Japanese Society of Developmental Bilogy
    • Place of Presentation
      島根県、くにびきメッセ
    • Year and Date
      2013-05-28
    • Related Report
      2013 Annual Research Report
  • [Presentation] 次世代実験動物としての遺伝子改変マーモセット2013

    • Author(s)
      佐々木えりか
    • Organizer
      IGM免疫生物分野講演会
    • Place of Presentation
      北海道、北海道大学フラテホール
    • Year and Date
      2013-05-21
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 標的遺伝子ノックダウンによるII型糖尿病モデルマーモセット作出の試み2013

    • Author(s)
      高橋司、前田拓志、久下壮、佐藤賢哉、佐々木えりか
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      茨城県、つくば国際会議場
    • Year and Date
      2013-05-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] 霊長類におけるクローン技術の開発2013

    • Author(s)
      外丸祐介、佐々木えりか
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      茨城県、つくば国際会議場
    • Year and Date
      2013-05-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] 霊長類の遺伝子改変動物モデル作製基盤 その将来2013

    • Author(s)
      佐々木えりか
    • Organizer
      第6回 In vivo 実験医学シンポジウム「再生医療と疾患モデル樹立への新たな挑戦」
    • Place of Presentation
      東京都、キャンパス・イノベーションセンター東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] コモンマーモセットの発生工学研究2013

    • Author(s)
      佐々木えりか
    • Organizer
      第2回日本マーモセット研究会大会
    • Place of Presentation
      東京都、慶應義塾大学三田キャンパス北館ホール
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Future prospects for utilizing transgenic marmoset as the human disease model2012

    • Author(s)
      Erika Sasaki
    • Organizer
      Joint Spring Meeting of the British Society for Cell Biology (BSCB), the British Society for Developmental Biology (BSDB) and the Japanese Society of Developmental Biologists (JSDB)
    • Place of Presentation
      Coventry, UK
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Transgenic non-human primate; a novel approach towards human disease models2012

    • Author(s)
      Erika Sasaki
    • Organizer
      WTCSCR Open Seminar
    • Place of Presentation
      Wellcome Trust Centre for Stem Cell Research, University of Cambridge, UK
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Transgenic marmoset; new model for biomedical science2012

    • Author(s)
      Erika Sasaki
    • Organizer
      6th Graduate School Meeting; ‘Cell Dynamics and Disease’
    • Place of Presentation
      Munster, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Attempt to Produce Newly Developed Transgenic Non-human Primate2012

    • Author(s)
      Erika Sasaki
    • Organizer
      5th International Symposium on Primate Research
    • Place of Presentation
      Kunming, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 小型霊長類コモンマーモセットを用いたiPS再生医療前臨床研究モデル2012

    • Author(s)
      佐々木えりか
    • Organizer
      第59回日本実験動物学会総会 シンポジウムV「ここまで来たiPS/ES細胞研究―実験動物からヒト臨床へ―」
    • Place of Presentation
      大分県、別府市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] マーモセットの発生工学研究2012

    • Author(s)
      佐々木えりか
    • Organizer
      京都大学霊長研・慶應義塾大学・理研・実中研合同セミナー
    • Place of Presentation
      愛知県岡崎市、京都大学霊長類研究所
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 遺伝子改変霊長類 現在の課題と新たな試み2012

    • Author(s)
      佐々木えりか
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      兵庫県神戸市、神戸国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] コモンマーモセット モデル動物としての可能性2012

    • Author(s)
      佐々木えりか
    • Organizer
      都医学研セミナー
    • Place of Presentation
      東京都、東京都医学総合研究所 講堂
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] iPS細胞で治療が実現するまでの道のり2012

    • Author(s)
      佐々木えりか
    • Organizer
      宮崎大学主催 市民シンポジウム「やさしく学ぶ iPS細胞 ~よくわかる iPS細胞研究の最前線~」
    • Place of Presentation
      宮崎県、宮崎市KITEN
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Genetically modified non-human primate models in life science2012

    • Author(s)
      Erika Sasaki
    • Organizer
      最先端研究開発支援プログラム「心を生み出す神経基盤の遺伝学的解析の戦略的展開」国際シンポジウム「幹細胞から見た神経発生」
    • Place of Presentation
      慶應義塾大学三田キャンパス北館ホール、東京都(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Future prospects for utilizing transgenic marmoset in biomedical research2012

    • Author(s)
      Erika Sasaki
    • Organizer
      Frontiers in Biomedical Researches on Marmosets as a Primate Model
    • Place of Presentation
      東京医科歯科大学M&Dタワー鈴木章夫記念講堂、東京都(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト疾患モデルとしてのコモンマーモセットの可能性2011

    • Author(s)
      佐々木えりか
    • Organizer
      第15回循環器再生医療研究会
    • Place of Presentation
      武田薬品工業株式会社東京本社、東京(招待講演)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 霊長類iPS細胞株樹立と染色体安定性2011

    • Author(s)
      佐々木えりか
    • Organizer
      第62回染色体学会年会
    • Place of Presentation
      平塚市中央公民館、神奈川(招待講演)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prospect for the future of use of transgenic marmoset in biomedical science2011

    • Author(s)
      Erika Sasaki
    • Organizer
      Mini-Symposium on Non-human Primate Models for Neural Diseases
    • Place of Presentation
      Shanghai, China(招待講演)
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stem cell research and preclinical research for regenerative medicine using non-human primate2011

    • Author(s)
      Erika Sasaki
    • Organizer
      6^<th> International Meeting of the Stem Cell Network
    • Place of Presentation
      Essen, Germany(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Establishment of non human primate preclinical study system for regenerative medicine2011

    • Author(s)
      Erika Sasaki
    • Organizer
      CAS International Symposium on Animal Models of Diseases
    • Place of Presentation
      Beijing, China(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] バイオメディカル研究における遺伝子改変霊長類2011

    • Author(s)
      佐々木えりか
    • Organizer
      第58回日本実験動物学会総会シンポジウム
    • Place of Presentation
      タワーホール船堀、東京都江戸川区(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Assisted reproductive techniques and production of genetically modified common marmoset2011

    • Author(s)
      Erika Sasaki
    • Organizer
      IMRG (International Marmoset Research Group) Kick-off Meeting
    • Place of Presentation
      Gottingen, Germany(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゲノム科学的脳高次機能研究の現在と将来2011

    • Author(s)
      佐々木えりか
    • Organizer
      第34回日本神経科学大会-こころの脳科学-シンポジウム
    • Place of Presentation
      パシフィコ横浜(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Book] 脳神経系の再生医学 発生と再生の融合的新展開2015

    • Author(s)
      井村裕夫(監修),高橋淳(監修),河﨑洋志(編集),赤木紀之,横田崇,末盛博文,升井伸治,山中伸弥,出澤真理,佐々木えりか他
    • Total Pages
      188
    • Publisher
      診断と治療社
    • Related Report
      2014 Annual Research Report
  • [Book] 遺伝子医学MOOK22号2012

    • Author(s)
      佐々木えりか
    • Publisher
      株式会社メディカルドゥ
    • Related Report
      2012 Annual Research Report
  • [Book] in vivo実験医学によるヒト疾患解明の最前線「トランスジェニックマーモセット作出と今後の実用化」2012

    • Author(s)
      佐々木えりか
    • Publisher
      羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] 月刊細胞工学変わりゆく発生工学の今:核移植クローン・遺伝子改変の技術革新からヒト化実験動物の開発まで「遺伝子改変非ヒト霊長類」2012

    • Author(s)
      佐々木えりか
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2011 Annual Research Report
  • [Book] FUTURE TRENDS IN PRIMATE TOXICOLOGY AND BIOTECHNOLOGY 「Novel Development in Reproductive Technologies for the Common Marmoset (Callithrix jacchus).」2011

    • Author(s)
      Ikuo Tomioka
    • Publisher
      Waxmann
    • Related Report
      2011 Annual Research Report
  • [Book] Methods in Molecular Biology 「Derivation of induced pluripotent stem cells by retroviral gene transduction in mammalian species.」2011

    • Author(s)
      Masanori Imamura
    • Publisher
      Springer(In press)
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2024-01-30  

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