| Budget Amount *help |
¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
Fiscal Year 2012: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2011: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2010: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
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| Research Abstract |
Helicobacter pylori CagA-positive strains play a key role in thedevelopment of gastric carcinoma. This project elucidated 1) the mechanism by which H. pylori delivers its oncoprotein CagA into host gastric epithelial cells: 2) identified Pragmin,a human protein the function of which is mimicked by delivered CagA: and 3) uncoveredmolecular pathway that directs reprograming of gastric epithelial cells into intestinal-likecells upon chronic infection with cagA-positive H. pylori. Finally, the H. pylori CagAprotein was crystalized and its three-dimensional structure was solved by X-ray analysis.
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