|Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2011: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2010: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
In order to understand the molecular relationship between the epigenetic modification of chromatin and DNA metabolism, and maintenance of chromosomal structure, we analyzed the histone code of silkworm holocentric chromosomes and its role on the formation of constitutive heterochromatin. First, the histone code of silkworm histone H3 was determined. Then, almost all components of H3K9-HP1and H3K27-Polycomb systems had been cloned and their roles on the formation of constitutive heterochromatin were analyzed. Finally, the molecular structure of silkworm kinetochore was revealed.