Phytophthora mating hormones: chemical biological studies including their receptors
Project/Area Number |
22248012
|
Research Category |
Grant-in-Aid for Scientific Research (A)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
Research Institution | Nagoya University |
Principal Investigator |
OJIKA Makoto 名古屋大学, 生命農学研究科, 教授 (50152492)
|
Co-Investigator(Kenkyū-buntansha) |
矢島 新 東京農業大学, 応用生物科学部, 准教授 (30328546)
|
Co-Investigator(Renkei-kenkyūsha) |
坂神 洋次 名古屋大学, 大学院生命農学研究科, 教授 (80107408)
|
Project Period (FY) |
2010-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥28,860,000 (Direct Cost: ¥22,200,000、Indirect Cost: ¥6,660,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
|
Keywords | 疫病菌 / Phytophthora / 交配ホルモン / 受容体 / 有性生殖 / 微生物 / 生理活性 / α2 / 卵胞子 |
Outline of Final Research Achievements |
Phytophthora is a genus that infects and damages important crops such as potatoes and tomatoes. This phytopathogen sexually reproduces using mating hormones (alpha 1 and alpha 2), which are secreted by A1 and A2 mating types, respectively. The identification of the mating hormones had been a long-pending problem. In this project, we determined the chemical structures of these mating hormones, clarified the structure-activity relationship, biosynthetic process, and hormone universality. Furthermore, to identify the hormone receptors, fluorescent probes of alpha 1 were synthesized and found to selectively stain the A2 mating type, which could furnish alpha 1 receptor.
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Report
(5 results)
Research Products
(17 results)