| Project/Area Number |
22249006
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Minoru 東京大学, 分子細胞生物学研究所, 准教授 (70526839)
AOYAMA Hiroshi 東京大学, 分子細胞生物学研究所, 助教 (40374699)
SUGITA Kazuyuki 東京大学, 分子細胞生物学研究所, 准教授 (60542090)
KOBAYASHI Hisayoshi 東京大学, 分子細胞生物学研究所, 助教 (80225531)
YACHIDE Tomomi 東京大学, 分子細胞生物学研究所, 技術職員 (20401284)
MATSUMOTO Yotaro 東京大学, 分子細胞生物学研究所, 助教 (90420041)
MISAWA Takashi 東京大学, 分子細胞生物学研究所, 助教 (40709820)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2011: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2010: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | トラフィッキング / フォールディング異常症 / 蛋白変性症 / マルチテンプレート / 核内受容体リガンド / 生理活性物質 / 蛋白質相互作用 / 膜タンパク質 / ニーマン・ピック病Ｃ型 / 酵素阻害剤 / 網膜色素変性症 / 変異ロドプシン |
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| Research Abstract |
Function, expression, stability and cellular localization of proteins are determined by their three dimensional structure. Therefore, control of the conformation of proteins results on regulation of their function/stability/localization. Abnormal conformation of specific proteins results in various incurable diseases. This research projects resulted in creation of: (1) various nuclear receptor ligands which control the function of the receptors by regulating their conformation, (2) small molecules (pharmacological chaperons) which correct abnormal trafficking of mutated proteins (ex. mutated rhodopsin which causes retinitis pigmentosa, NPC1 which caused Niemann-Pick type 1 disease), and (3) small molecules (SNIPERS) which induce degradation of target proteins in living cells.
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