Development of molecular imaging probes for measurement of mass in pancreatic islets.
Project/Area Number |
22249046
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kyoto University |
Principal Investigator |
SAJI Hideo 京都大学, 大学院・薬学研究科, 教授 (40115853)
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Co-Investigator(Kenkyū-buntansha) |
TOYODA Koichi 京都大学, 大学院・医学研究科, 講師 (00447971)
UEDA Masashi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (40381967)
KITAMURA Hiroyoki 京都大学, 放射性同位元素総合センター, 助教 (50437240)
KAWASHIMA Hidekazu 国立循環器病センター, 画像診断医学部, 室長 (70359438)
TEMMA Takashi 京都大学, 大学院・薬学研究科, 助教 (90378787)
小野 正博 京都大学, 薬学研究科, 准教授 (80336180)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥48,880,000 (Direct Cost: ¥37,600,000、Indirect Cost: ¥11,280,000)
Fiscal Year 2012: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2010: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
|
Keywords | 膵島β細胞 / 分子イメージング / 糖尿病 / 早期診断 |
Research Abstract |
If a decrease in the amount of pancreatic islets and the amount of pancreatic β-cells can be detected at an early stage, there is a possibility for the prevention and treatment of diabetes. Therefore, a noninvasive technique for imaging of pancreatic islets, particularly a noninvasive technique for imaging of pancreatic islets for determining the amount of the pancreatic islets and the amount of pancreatic β-cells, has been desired for the prevention and diagnosis of diabetes. Among these, a molecular probe that enables the imaging of pancreatic islets, preferably the pancreatic β-cell imaging, has been desired in particular. In designing a molecular probe f or imaging of pancreatic β-cells, various targets molecule in pancreatic islet cells, particularly functional proteins specific in the β-cells, are being researched. Among these, GLP-1R, GPR40 and GLUT2 are being researched as a target molecule.
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Report
(4 results)
Research Products
(57 results)
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[Presentation] Development of Non-Invasive PET Probe for Quantifying Pancreatic β-Call Mass Using Fluorine-18-Labeled Exendin-4.2012
Author(s)
Fujimoto H, Toyoda K, Kimura H, Ogawa Y, Mukai E, Zhuang X, Ueda M, Temma T, Hirai M, Matsuda H, Saji H, Inagaki N
Organizer
9th Internationa Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes.
Place of Presentation
Kyoto
Year and Date
2012-11-27
Related Report
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[Presentation] 膵β細胞 GLP-1受容体を標的とする SPECT 用イメージングプローブの開発2011
Author(s)
小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎
Organizer
日本薬学会第131年会
Place of Presentation
静岡
Year and Date
2011-03-30
Related Report
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[Presentation] スルホニル尿素受容体 SUR1 を標的とした膵β細胞イメージング用放射性分子プローブの開発2011
Author(s)
松田洋和,木村寛之,小川祐,豊田健太郎,向英里,藤本裕之,中村博,平尾佳,小野正博,稲垣暢也,佐治英郎
Organizer
日本薬学会第131年会
Place of Presentation
静岡
Year and Date
2011-03-29
Related Report
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[Presentation] Non-Invasive PET Imaging of Pancreatic Islets Targeting Glucagon-Like Peptide-1 Receptors2010
Author(s)
Toyoda K, Kimura H, Mukai E, Fujimoto H, Ogawa Y, Kawashima H, Ueda M, Temma T, Hirao K, Nagakawa K, Seino Y, Saji H, Inagaki N
Organizer
8th IDF WPR Congress
Place of Presentation
Busan, Korea
Year and Date
2010-10-20
Related Report
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[Presentation] Non-Invasive PET Imaging of Pancreatic Islets Targeting Glucagon-Like Peptide-1 Receptors2010
Author(s)
Toyoda K, Kimura H, Mukai E, Fujimoto H, Ogawa Y, Kawashima H, Ueda M, Temma T, Hirao K, Nagakawa K, Seino Y, Saji H, Inagaki N
Organizer
American Diabetes Association 70th Scientific Sessions
Place of Presentation
Orland, USA
Year and Date
2010-06-28
Related Report
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[Presentation] Synthesis and evaluation of radioiodinated exendin derivatives for the imaging of GLP-1 receptor expression in pancreatic islets.2010
Author(s)
Kimura H, Ogawa Y, Kawashima H, Mukai E, Toyoda K, Fujimoto H, Hirao K, Ono M, Inagaki N, Saji H
Organizer
Society of Nuclear Medicine 57^<th> Annual Meeting
Place of Presentation
Salt Lake City, USA
Year and Date
2010-06-08
Related Report
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[Presentation] GLP-1 受容体を標的とする放射性ヨウ素標識イメージングプローブの開発2010
Author(s)
小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎
Organizer
第50回日本核医学会学術総会
Place of Presentation
大宮
Related Report
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[Presentation] SUR1 受容体を標的とした膵β細胞イメージング用放射性プローブの開発2010
Author(s)
松田洋和, 木村寛之, 小川祐, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 小野正博, 稲垣暢也, 佐治英郎
Organizer
第50回日本核医学会学術総会
Place of Presentation
大宮
Related Report
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[Presentation] Development of Non-Invasive PET Probe for Quantifying Pancreatic β-Call Mass Using Fluorine-18-Labeled Exendin-4
Author(s)
Fujimoto H, Toyoda K, Kimura H, Ogawa Y, Mukai E, Zhuang X, Ueda M, Temma T, Hirai M, Matsuda H, Saji H, Inagaki N
Organizer
9th Internationa Diabetes Federation Western Pacific Region Congress / 4th Scientific Meeting of the Asian Association for the Study of Diabetes
Place of Presentation
国立京都国際会館(京都府)
Related Report
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