Association of life-style related risk factors with the pathology of dementia
| Project/Area Number |
22300116
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyushu University |
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Principal Investigator |
IWAKI Toru 九州大学, 医学研究院, 教授 (40221098)
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| Research Collaborator |
KIYOHARA Yutaka 九州大学, 大学院医学研究院, 教授 (80161602)
SASAKI Kensuke 九州大学, 大学院医学研究院, 助教 (80380616)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 老化性痴呆疾患 / 認知症 / アルツハイマー病 / 耐糖能異常 / インスリン抵抗性 / 脂質代謝異常 / 老人斑 / 脳血管性認知症 / 病理解剖 / 神経原線維変化 / タウ蛋白質 / 数理解析ソフト / 生活習慣病 / コレステロール / 糖尿病 |
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| Research Abstract |
The epidemiological studies indicate that the prevalence of Alzheimer disease is increasing at an accelerating pace in parallel with an increase of metabolic disorders. We reported that insulin resistance is associated with the plaque-type pathology of Alzheimer disease. Next, we have shown that dyslipidemia may also be an independent risk factor for neuritic plaque formation.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Autosomal dominant tauopathy with parkinsonism and central hypoventilation2012
Author(s)
Omoto M, Suzuki SO, Ikeuchi T, Ishihara T, Kobayashi T, Tsuboi Y, Ogasawara J, Koga M, Kawai M, Iwaki T, Kanda T
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Journal Title
Neurology
Volume: 78
Issue: 10
Pages: 762-764
DOI
Related Report
Peer Reviewed
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