| Project/Area Number |
22300126
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Nagoya University |
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Principal Investigator |
ODA Yoichi 名古屋大学, 理学(系)研究科(研究院), 教授 (00144444)
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| Co-Investigator(Kenkyū-buntansha) |
SHIN Takagi 名古屋大学, 大学院理学研究科, 准教授 (90171420)
MASASHI Tanimoto 名古屋大学, 大学院理学研究科, 助教 (30608716)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 内耳 / 有毛細胞 / 耳石 / 球形嚢 / 卵形嚢 / マウスナー細胞 / カリウムチャネル / ゼブラフィッシュ / 網様体脊髄路ニューロン / キンギョ / 聴覚 / 触覚 / 逃避運動 / 機械受容 / 発火パターン |
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| Research Abstract |
The developmental origin of inner ear hair cells, role of ear stone size on acoustic sensitivity and molecular mechanisms underlying developmental change in firing properties of hindbrain neurons were studied in vivo in zebrafish embryos and larvae. We demonstrated first that tether cells, a few ciliated cells associated with an ear stone (otolith) in the embryonic inner ear, morphologically and functionally differentiate into first hair cells. Second, the saccule inner ear organ containing a large otolith is necessary to detect sound, whereas the utricle containing a small otolith is not. But, utricle hair cells with experimentally enlarged otoliths acquired the sense of sound, suggesting that otolith size is crucial to sense sound. Third, unique firing properties of Mauthner cells among the hindbrain reticulospinal neurons receiving auditory nerve inputs are acquired during early development and coexpression of Kv beta subunits with low-threshold Kv1 subunits is required for them.
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